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Article: Evolutionary and transmission dynamics of reassortant H5N1 influenza virus in Indonesia

TitleEvolutionary and transmission dynamics of reassortant H5N1 influenza virus in Indonesia
Authors
Issue Date2008
PublisherPublic Library of Science. The Journal's web site is located at http://pathogens.plosjournals.org/perlserv/?request=index-html&issn=1553-7374
Citation
Plos Pathogens, 2008, v. 4 n. 8 How to Cite?
AbstractH5N1 highly pathogenic avian influenza (HPAI) viruses have seriously affected the Asian poultry industry since their recurrence in 2003. The viruses pose a threat of emergence of a global pandemic influenza through point mutation or reassortment leading to a strain that can effectively transmit among humans. In this study, we present phylogenetic evidences for the interlineage reassortment among H5N1 HPAI viruses isolated from humans, cats, and birds in Indonesia, and identify the potential genetic parents of the reassorted genome segments. Parsimony analyses of viral phylogeography suggest that the reassortant viruses may have originated from greater Jakarta and surroundings, and subsequently spread to other regions in the West Java province. In addition, Bayesian methods were used to elucidate the genetic diversity dynamics of the reassortant strain and one of its genetic parents, which revealed a more rapid initial growth of genetic diversity in the reassortant viruses relative to their genetic parent. These results demonstrate that interlineage exchange of genetic information may play a pivotal role in determining viral genetic diversity in a focal population. Moreover, our study also revealed significantly stronger diversifying selection on the M1 and PB2 genes in the lineages preceding and subsequent to the emergence of the reassortant viruses, respectively. We discuss how the corresponding mutations might drive the adaptation and onward transmission of the newly formed reassortant viruses. © 2008 Lam et al.
Persistent Identifierhttp://hdl.handle.net/10722/60679
ISSN
2015 Impact Factor: 7.003
2015 SCImago Journal Rankings: 5.185
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Institutes of HealthAI43638
AI47745
AI57167
University of California Universitywide AIDS Research ProgramIS02-SD-701
University of California-San Diego Center for AIDS Research/NIAID Developmental AwardAI36214
Funding Information:

This work was partly funded and supported by research grant RFCID 06060672 from the Hong Kong Government and The University of Hong Kong Faculty of Science Research Development Fund to FCCL. OGP is supported by the Royal Society. This research was supported in part by the National Institutes of Health (AI43638, AI47745, and AI57167), the University of California Universitywide AIDS Research Program (grant number IS02-SD-701), and by a University of California-San Diego Center for AIDS Research/NIAID Developmental Award to SLKP (AI36214).

References

 

DC FieldValueLanguage
dc.contributor.authorLam, TTYen_HK
dc.contributor.authorHon, CCen_HK
dc.contributor.authorPybus, OGen_HK
dc.contributor.authorKosakovsky Pond, SLen_HK
dc.contributor.authorWong, RTYen_HK
dc.contributor.authorYip, CWen_HK
dc.contributor.authorZeng, Fen_HK
dc.contributor.authorLeung, FCCen_HK
dc.date.accessioned2010-05-31T04:16:22Z-
dc.date.available2010-05-31T04:16:22Z-
dc.date.issued2008en_HK
dc.identifier.citationPlos Pathogens, 2008, v. 4 n. 8en_HK
dc.identifier.issn1553-7366en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60679-
dc.description.abstractH5N1 highly pathogenic avian influenza (HPAI) viruses have seriously affected the Asian poultry industry since their recurrence in 2003. The viruses pose a threat of emergence of a global pandemic influenza through point mutation or reassortment leading to a strain that can effectively transmit among humans. In this study, we present phylogenetic evidences for the interlineage reassortment among H5N1 HPAI viruses isolated from humans, cats, and birds in Indonesia, and identify the potential genetic parents of the reassorted genome segments. Parsimony analyses of viral phylogeography suggest that the reassortant viruses may have originated from greater Jakarta and surroundings, and subsequently spread to other regions in the West Java province. In addition, Bayesian methods were used to elucidate the genetic diversity dynamics of the reassortant strain and one of its genetic parents, which revealed a more rapid initial growth of genetic diversity in the reassortant viruses relative to their genetic parent. These results demonstrate that interlineage exchange of genetic information may play a pivotal role in determining viral genetic diversity in a focal population. Moreover, our study also revealed significantly stronger diversifying selection on the M1 and PB2 genes in the lineages preceding and subsequent to the emergence of the reassortant viruses, respectively. We discuss how the corresponding mutations might drive the adaptation and onward transmission of the newly formed reassortant viruses. © 2008 Lam et al.en_HK
dc.languageengen_HK
dc.publisherPublic Library of Science. The Journal's web site is located at http://pathogens.plosjournals.org/perlserv/?request=index-html&issn=1553-7374en_HK
dc.relation.ispartofPLoS Pathogensen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAnimals-
dc.subject.meshEvolution, Molecular-
dc.subject.meshInfluenza A Virus, H5N1 Subtype - genetics - pathogenicity-
dc.subject.meshInfluenza in Birds - epidemiology - genetics - transmission-
dc.subject.meshPoultry Diseases - epidemiology - genetics - transmission-
dc.titleEvolutionary and transmission dynamics of reassortant H5N1 influenza virus in Indonesiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1553-7366&volume=4&issue=8&spage=e1000130&epage=&date=2008&atitle=Evolutionary+and+transmission+dynamics+of+reassortant+H5n1+Influenza+virus+In+Indonesia-
dc.identifier.emailLam, TTY: ttylam@hku.hken_HK
dc.identifier.emailLeung, FCC: fcleung@hkucc.hku.hken_HK
dc.identifier.authorityLam, TTY=rp01733en_HK
dc.identifier.authorityLeung, FCC=rp00731en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.ppat.1000130en_HK
dc.identifier.pmid18725937-
dc.identifier.pmcidPMC2515348-
dc.identifier.scopuseid_2-s2.0-50849143158en_HK
dc.identifier.hkuros166180en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-50849143158&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume4en_HK
dc.identifier.issue8en_HK
dc.identifier.spagee1000130-
dc.identifier.epagee1000130-
dc.identifier.isiWOS:000259783100018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLam, TTY=36775821700en_HK
dc.identifier.scopusauthoridHon, CC=7003617137en_HK
dc.identifier.scopusauthoridPybus, OG=6701390795en_HK
dc.identifier.scopusauthoridKosakovsky Pond, SL=7801633431en_HK
dc.identifier.scopusauthoridWong, RTY=36812007300en_HK
dc.identifier.scopusauthoridYip, CW=7101665559en_HK
dc.identifier.scopusauthoridZeng, F=7202911544en_HK
dc.identifier.scopusauthoridLeung, FCC=7103078633en_HK
dc.identifier.citeulike3292588-

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