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Article: Gonadotropin-releasing hormone: Regulation of the GnRH gene

TitleGonadotropin-releasing hormone: Regulation of the GnRH gene
Authors
KeywordsEstrogen
Follicle-stimulating hormone
GnRH
Gonadotropin
Luteinizing hormone
PKC signalling
Progesterone
Promoter
Steroid hormone
Transcriptional regulation
Issue Date2008
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.febsjournal.org/
Citation
Febs Journal, 2008, v. 275 n. 22, p. 5458-5478 How to Cite?
AbstractAs the key regulator of reproduction, gonadotropin-releasing hormone (GnRH) is released by neurons in the hypothalamus, and transported via the hypothalamo-hypophyseal portal circulation to the anterior pituitary to trigger gonadotropin release for gonadal steroidogenesis and gametogenesis. To achieve appropriate reproductive function, mammals have precise regulatory mechanisms; one of these is the control of GnRH synthesis and release. In the past, the scarcity of GnRH neurons and their widespread distribution in the brain hindered the study of GnRH gene expression. Until recently, the development of GnRH-expressing cell lines with properties similar to those of in vivo GnRH neurons and also transgenic mice facilitated GnRH gene regulation research. This minireview provides a summary of the molecular mechanisms for the control of GnRH-I and GnRH-II gene expression. These include basal transcription regulation, which involves essential cis-acting elements in the GnRH-I and GnRH-II promoters and interacting transcription factors, and also feedback control by gonadotropins and gonadal sex steroids. Other physiological stimuli, e.g. insulin and melatonin, will also be discussed. © 2008 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/60649
ISSN
2015 Impact Factor: 4.237
2015 SCImago Journal Rankings: 2.141
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, VHYen_HK
dc.contributor.authorLee, LTOen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2010-05-31T04:15:49Z-
dc.date.available2010-05-31T04:15:49Z-
dc.date.issued2008en_HK
dc.identifier.citationFebs Journal, 2008, v. 275 n. 22, p. 5458-5478en_HK
dc.identifier.issn1742-464Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/60649-
dc.description.abstractAs the key regulator of reproduction, gonadotropin-releasing hormone (GnRH) is released by neurons in the hypothalamus, and transported via the hypothalamo-hypophyseal portal circulation to the anterior pituitary to trigger gonadotropin release for gonadal steroidogenesis and gametogenesis. To achieve appropriate reproductive function, mammals have precise regulatory mechanisms; one of these is the control of GnRH synthesis and release. In the past, the scarcity of GnRH neurons and their widespread distribution in the brain hindered the study of GnRH gene expression. Until recently, the development of GnRH-expressing cell lines with properties similar to those of in vivo GnRH neurons and also transgenic mice facilitated GnRH gene regulation research. This minireview provides a summary of the molecular mechanisms for the control of GnRH-I and GnRH-II gene expression. These include basal transcription regulation, which involves essential cis-acting elements in the GnRH-I and GnRH-II promoters and interacting transcription factors, and also feedback control by gonadotropins and gonadal sex steroids. Other physiological stimuli, e.g. insulin and melatonin, will also be discussed. © 2008 The Authors.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.febsjournal.org/en_HK
dc.relation.ispartofFEBS Journalen_HK
dc.rightsThe F E B S Journal. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectEstrogenen_HK
dc.subjectFollicle-stimulating hormoneen_HK
dc.subjectGnRHen_HK
dc.subjectGonadotropinen_HK
dc.subjectLuteinizing hormoneen_HK
dc.subjectPKC signallingen_HK
dc.subjectProgesteroneen_HK
dc.subjectPromoteren_HK
dc.subjectSteroid hormoneen_HK
dc.subjectTranscriptional regulationen_HK
dc.titleGonadotropin-releasing hormone: Regulation of the GnRH geneen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1742-464X&volume=275&issue=22&spage=5458&epage=5478&date=2008&atitle=Gonadotropin-releasing+hormone:+regulation+of+the+GnRH+gene.en_HK
dc.identifier.emailLee, LTO: ltolee2@hkucc.hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.authorityLee, LTO=rp00727en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1742-4658.2008.06676.xen_HK
dc.identifier.pmid18959737en_HK
dc.identifier.scopuseid_2-s2.0-54849421553en_HK
dc.identifier.hkuros153402en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-54849421553&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume275en_HK
dc.identifier.issue22en_HK
dc.identifier.spage5458en_HK
dc.identifier.epage5478en_HK
dc.identifier.isiWOS:000260348600002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLee, VHY=14050662700en_HK
dc.identifier.scopusauthoridLee, LTO=8367269000en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK
dc.identifier.citeulike3454869-

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