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Article: Functional alterations of Lin-CD34+CD38+ cells in chronic myelomonocytic leukemia and on progression to acute leukemia

TitleFunctional alterations of Lin-CD34+CD38+ cells in chronic myelomonocytic leukemia and on progression to acute leukemia
Authors
Issue Date2008
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/leukres
Citation
Leukemia Research, 2008, v. 32 n. 9, p. 1374-1381 How to Cite?
Abstract
The functional behavior of hematopoietic stem cell (HSC) and progenitors in chronic myelomonocytic leukemia (CMML) and on disease progression is little known. We performed cell proliferation, apoptosis, hematopoietic colony forming/replating and differentiation potential studies in the purified subpopulations of Lin-CD34+CD38- and Lin-CD34+CD38+ cells from 16 CMML with 6 cases after acute myeloid leukemia transformation (AML-t). We observed an expansion of the hematopoietic progenitor pool (Lin-CD34+ cells) in AML-t comprising mainly Lin-CD34+CD38+ cells. The Lin-CD34+CD38+ cells in AML-t displayed high proliferative activity, resistance to apoptosis, enhanced myeloid colony formation/replating ability and a complete dendritic cell (DC) differentiation block. Our findings suggest Lin-CD34+CD38+ cells instead of Lin-CD34+CD38- cells could be the target(s) of secondary genetic lesions underpinning progression from CMML to AML, which have implications for the further study of the biology of leukemic transformation and the design of new strategies for the effective treatment of CMML. © 2008 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/60574
ISSN
2013 Impact Factor: 2.692
2013 SCImago Journal Rankings: 1.080
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Queen Mary Hospital Hong Kong
DC FieldValueLanguage
dc.contributor.authorSun, Qen_HK
dc.contributor.authorSo, CCen_HK
dc.contributor.authorYip, SFen_HK
dc.contributor.authorWan, TSKen_HK
dc.contributor.authorMa, SKen_HK
dc.contributor.authorChan, LCen_HK
dc.date.accessioned2010-05-31T04:13:58Z-
dc.date.available2010-05-31T04:13:58Z-
dc.date.issued2008en_HK
dc.identifier.citationLeukemia Research, 2008, v. 32 n. 9, p. 1374-1381en_HK
dc.identifier.issn0145-2126en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60574-
dc.description.abstractThe functional behavior of hematopoietic stem cell (HSC) and progenitors in chronic myelomonocytic leukemia (CMML) and on disease progression is little known. We performed cell proliferation, apoptosis, hematopoietic colony forming/replating and differentiation potential studies in the purified subpopulations of Lin-CD34+CD38- and Lin-CD34+CD38+ cells from 16 CMML with 6 cases after acute myeloid leukemia transformation (AML-t). We observed an expansion of the hematopoietic progenitor pool (Lin-CD34+ cells) in AML-t comprising mainly Lin-CD34+CD38+ cells. The Lin-CD34+CD38+ cells in AML-t displayed high proliferative activity, resistance to apoptosis, enhanced myeloid colony formation/replating ability and a complete dendritic cell (DC) differentiation block. Our findings suggest Lin-CD34+CD38+ cells instead of Lin-CD34+CD38- cells could be the target(s) of secondary genetic lesions underpinning progression from CMML to AML, which have implications for the further study of the biology of leukemic transformation and the design of new strategies for the effective treatment of CMML. © 2008 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/leukresen_HK
dc.relation.ispartofLeukemia Researchen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAntigens, CD34 - metabolismen_HK
dc.subject.meshAntigens, CD38 - metabolismen_HK
dc.subject.meshApoptosis - physiologyen_HK
dc.subject.meshCell Cycle - physiologyen_HK
dc.subject.meshCell Proliferationen_HK
dc.subject.meshCell Transformation, Neoplasticen_HK
dc.subject.meshColony-Forming Units Assayen_HK
dc.subject.meshDendritic Cells - metabolismen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshFlow Cytometryen_HK
dc.subject.meshGranulocyte Colony-Stimulating Factor - administration & dosageen_HK
dc.subject.meshHematopoietic Stem Cellsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLeukemia, Myeloid, Acute - metabolism - pathologyen_HK
dc.subject.meshLeukemia, Myelomonocytic, Chronic - metabolism - pathologyen_HK
dc.subject.meshMembrane Glycoproteins - metabolismen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshTumor Necrosis Factor-alpha - pharmacologyen_HK
dc.titleFunctional alterations of Lin-CD34+CD38+ cells in chronic myelomonocytic leukemia and on progression to acute leukemiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0145-2126&volume=32&issue=9&spage=1374&epage=1381&date=2008&atitle=Functional+alterations+of+Lin-CD34+CD38++cells+in+chronic+myelomonocytic+leukemia+and+on+progression+to+acute+leukemiaen_HK
dc.identifier.emailSo, CC:scc@pathology.hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authoritySo, CC=rp00391en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.leukres.2008.02.011en_HK
dc.identifier.pmid18372040en_HK
dc.identifier.scopuseid_2-s2.0-43149110811en_HK
dc.identifier.hkuros150513en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-43149110811&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1374en_HK
dc.identifier.epage1381en_HK
dc.identifier.isiWOS:000256650800007-
dc.publisher.placeUnited Kingdomen_HK

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