Article: Functional alterations of Lin-CD34+CD38+ cells in chronic myelomonocytic leukemia and on progression to acute leukemia

File Download Links for fulltext
(May Require Subscription)
Supplementary
  • Basic View
  • Metadata View
  • XML View
TitleFunctional alterations of Lin-CD34+CD38+ cells in chronic myelomonocytic leukemia and on progression to acute leukemia
AuthorsSun, Q1
So, CC1
Yip, SF2
Wan, TSK2
Ma, SK1
Chan, LC1
Issue Date2008
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/leukres
CitationLeukemia Research, 2008, v. 32 n. 9, p. 1374-1381 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.leukres.2008.02.011
AbstractThe functional behavior of hematopoietic stem cell (HSC) and progenitors in chronic myelomonocytic leukemia (CMML) and on disease progression is little known. We performed cell proliferation, apoptosis, hematopoietic colony forming/replating and differentiation potential studies in the purified subpopulations of Lin-CD34+CD38- and Lin-CD34+CD38+ cells from 16 CMML with 6 cases after acute myeloid leukemia transformation (AML-t). We observed an expansion of the hematopoietic progenitor pool (Lin-CD34+ cells) in AML-t comprising mainly Lin-CD34+CD38+ cells. The Lin-CD34+CD38+ cells in AML-t displayed high proliferative activity, resistance to apoptosis, enhanced myeloid colony formation/replating ability and a complete dendritic cell (DC) differentiation block. Our findings suggest Lin-CD34+CD38+ cells instead of Lin-CD34+CD38- cells could be the target(s) of secondary genetic lesions underpinning progression from CMML to AML, which have implications for the further study of the biology of leukemic transformation and the design of new strategies for the effective treatment of CMML. © 2008 Elsevier Ltd. All rights reserved.
ISSN0145-2126
2011 Impact Factor: 2.923
2011 SCImago Journal Rankings: 0.232
DOIhttp://dx.doi.org/10.1016/j.leukres.2008.02.011
ISI Accession Number IDWOS:000256650800007
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorSun, Q
dc.contributor.authorSo, CC
dc.contributor.authorYip, SF
dc.contributor.authorWan, TSK
dc.contributor.authorMa, SK
dc.contributor.authorChan, LC
dc.date.accessioned2010-05-31T04:13:58Z
dc.date.available2010-05-31T04:13:58Z
dc.date.issued2008
dc.description.abstractThe functional behavior of hematopoietic stem cell (HSC) and progenitors in chronic myelomonocytic leukemia (CMML) and on disease progression is little known. We performed cell proliferation, apoptosis, hematopoietic colony forming/replating and differentiation potential studies in the purified subpopulations of Lin-CD34+CD38- and Lin-CD34+CD38+ cells from 16 CMML with 6 cases after acute myeloid leukemia transformation (AML-t). We observed an expansion of the hematopoietic progenitor pool (Lin-CD34+ cells) in AML-t comprising mainly Lin-CD34+CD38+ cells. The Lin-CD34+CD38+ cells in AML-t displayed high proliferative activity, resistance to apoptosis, enhanced myeloid colony formation/replating ability and a complete dendritic cell (DC) differentiation block. Our findings suggest Lin-CD34+CD38+ cells instead of Lin-CD34+CD38- cells could be the target(s) of secondary genetic lesions underpinning progression from CMML to AML, which have implications for the further study of the biology of leukemic transformation and the design of new strategies for the effective treatment of CMML. © 2008 Elsevier Ltd. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationLeukemia Research, 2008, v. 32 n. 9, p. 1374-1381 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.leukres.2008.02.011
dc.identifier.doihttp://dx.doi.org/10.1016/j.leukres.2008.02.011
dc.identifier.epage1381
dc.identifier.hkuros150513
dc.identifier.isiWOS:000256650800007
dc.identifier.issn0145-2126
2011 Impact Factor: 2.923
2011 SCImago Journal Rankings: 0.232
dc.identifier.issue9
dc.identifier.openurl
dc.identifier.pmid18372040
dc.identifier.scopuseid_2-s2.0-43149110811
dc.identifier.spage1374
dc.identifier.urihttp://hdl.handle.net/10722/60574
dc.identifier.volume32
dc.languageeng
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/leukres
dc.publisher.placeUnited Kingdom
dc.relation.ispartofLeukemia Research
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshAntigens, CD34 - metabolism
dc.subject.meshAntigens, CD38 - metabolism
dc.subject.meshApoptosis - physiology
dc.subject.meshCell Cycle - physiology
dc.subject.meshCell Proliferation
dc.subject.meshCell Transformation, Neoplastic
dc.subject.meshColony-Forming Units Assay
dc.subject.meshDendritic Cells - metabolism
dc.subject.meshDisease Progression
dc.subject.meshFlow Cytometry
dc.subject.meshGranulocyte Colony-Stimulating Factor - administration & dosage
dc.subject.meshHematopoietic Stem Cells
dc.subject.meshHumans
dc.subject.meshLeukemia, Myeloid, Acute - metabolism - pathology
dc.subject.meshLeukemia, Myelomonocytic, Chronic - metabolism - pathology
dc.subject.meshMembrane Glycoproteins - metabolism
dc.subject.meshMiddle Aged
dc.subject.meshTumor Necrosis Factor-alpha - pharmacology
dc.titleFunctional alterations of Lin-CD34+CD38+ cells in chronic myelomonocytic leukemia and on progression to acute leukemia
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Queen Mary Hospital Hong Kong