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Article: Pathogenesis of choriocarcinoma: Clinical, genetic and stem cell perspectives

TitlePathogenesis of choriocarcinoma: Clinical, genetic and stem cell perspectives
Authors
KeywordsChoriocarcinoma
Dedifferentiation
Germ cell tumors
Gestational trophoblastic disease
Stem cell
Issue Date2009
PublisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/fon
Citation
Future Oncology, 2009, v. 5 n. 2, p. 217-231 How to Cite?
AbstractChoriocarcinoma is a unique malignant neoplasm composed of mononuclear cytotrophoblasts and multinucleated syncytiotrophoblasts that produce human chorionic-gonadotrophin. Choriocarcinoma can occur after a pregnancy, as a component of germ cell tumors, or in association with a poorly differentiated somatic carcinoma, each with distinct clinical features. Cytogenetic and molecular studies, predominantly on gestational choriocarcinoma, revealed the impact of oncogenes, tumor suppressor genes and imprinting genes on its pathogenesis. The role of stem cells in various types of choriocarcinoma has been studied recently. This review will discuss how such knowledge can enhance our understanding of the pathogenesis of choriocarcinoma, enable exploration of novel anti-choriocarcinoma targeted therapy and possibly improve our insight on embryological and placental development. © 2009 Future Medicine Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/60572
ISSN
2015 Impact Factor: 2.129
2015 SCImago Journal Rankings: 0.957
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorZhang, HJen_HK
dc.contributor.authorXue, WCen_HK
dc.contributor.authorSiu, MKYen_HK
dc.date.accessioned2010-05-31T04:13:56Z-
dc.date.available2010-05-31T04:13:56Z-
dc.date.issued2009en_HK
dc.identifier.citationFuture Oncology, 2009, v. 5 n. 2, p. 217-231en_HK
dc.identifier.issn1479-6694en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60572-
dc.description.abstractChoriocarcinoma is a unique malignant neoplasm composed of mononuclear cytotrophoblasts and multinucleated syncytiotrophoblasts that produce human chorionic-gonadotrophin. Choriocarcinoma can occur after a pregnancy, as a component of germ cell tumors, or in association with a poorly differentiated somatic carcinoma, each with distinct clinical features. Cytogenetic and molecular studies, predominantly on gestational choriocarcinoma, revealed the impact of oncogenes, tumor suppressor genes and imprinting genes on its pathogenesis. The role of stem cells in various types of choriocarcinoma has been studied recently. This review will discuss how such knowledge can enhance our understanding of the pathogenesis of choriocarcinoma, enable exploration of novel anti-choriocarcinoma targeted therapy and possibly improve our insight on embryological and placental development. © 2009 Future Medicine Ltd.en_HK
dc.languageengen_HK
dc.publisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/fonen_HK
dc.relation.ispartofFuture Oncologyen_HK
dc.subjectChoriocarcinomaen_HK
dc.subjectDedifferentiationen_HK
dc.subjectGerm cell tumorsen_HK
dc.subjectGestational trophoblastic diseaseen_HK
dc.subjectStem cellen_HK
dc.titlePathogenesis of choriocarcinoma: Clinical, genetic and stem cell perspectivesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1479-6694&volume=5&issue=2&spage=217&epage=231&date=2009&atitle=Pathogenesis+of+choriocarcinoma:+clinical,+genetic+and+stem+cell+perspectivesen_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.emailSiu, MKY: mkysiu@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authoritySiu, MKY=rp00275en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2217/14796694.5.2.217en_HK
dc.identifier.pmid19284380-
dc.identifier.scopuseid_2-s2.0-66349101372en_HK
dc.identifier.hkuros166034en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-66349101372&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue2en_HK
dc.identifier.spage217en_HK
dc.identifier.epage231en_HK
dc.identifier.isiWOS:000264469800015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridZhang, HJ=8597830900en_HK
dc.identifier.scopusauthoridXue, WC=26640823700en_HK
dc.identifier.scopusauthoridSiu, MKY=24924018400en_HK
dc.identifier.citeulike4201314-

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