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Article: Timing of intraoperative parecoxib analgesia in colorectal surgery

TitleTiming of intraoperative parecoxib analgesia in colorectal surgery
Authors
KeywordsAnalgesia
Inflammation
Parecoxib
Surgical injury
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/acpain
Citation
Acute Pain, 2008, v. 10 n. 3-4, p. 123-130 How to Cite?
AbstractObjective: The aim of this study was to determine the analgesic effect of parecoxib when administered either before or at the end of surgery in patients undergoing colorectal laparotomy. Methods: Sixty patients were randomised to three groups of 20. The PS group received intravenous parecoxib 40 mg before skin incision and normal saline at skin closure. The SP group received saline before skin incision and intravenous parecoxib 40 mg at skin closure. A control group (SS) received saline at both time points. Results: In both SP and PS groups, morphine consumption was smaller. There was a 40-55% reduction in cumulative morphine consumption in both treatment groups at all time points up to 48 h after anaesthesia finished. The greatest reduction was from 12 h to 24 h which showed a 66% reduction for the SP group and a 55% reduction for the PS group compared to control (p = 0.0003 and 0.0049, respectively, with an adjusted significance value = 0.0167). For SP and PS groups, the time to first post-operative analgesic request tended to be longer and the number of patients requesting morphine in the recovery room was less. Conclusion: Parecoxib administration at the end of surgery is as effective as at the beginning with regard to analgesic and opioid-sparing effects. © 2008 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/60409
ISSN
2012 SCImago Journal Rankings: 0.172
References

 

DC FieldValueLanguage
dc.contributor.authorLee, LHen_HK
dc.contributor.authorIrwin, MGen_HK
dc.contributor.authorYao, TJen_HK
dc.contributor.authorYuen, MKen_HK
dc.contributor.authorCheung, CWen_HK
dc.date.accessioned2010-05-31T04:10:15Z-
dc.date.available2010-05-31T04:10:15Z-
dc.date.issued2008en_HK
dc.identifier.citationAcute Pain, 2008, v. 10 n. 3-4, p. 123-130en_HK
dc.identifier.issn1366-0071en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60409-
dc.description.abstractObjective: The aim of this study was to determine the analgesic effect of parecoxib when administered either before or at the end of surgery in patients undergoing colorectal laparotomy. Methods: Sixty patients were randomised to three groups of 20. The PS group received intravenous parecoxib 40 mg before skin incision and normal saline at skin closure. The SP group received saline before skin incision and intravenous parecoxib 40 mg at skin closure. A control group (SS) received saline at both time points. Results: In both SP and PS groups, morphine consumption was smaller. There was a 40-55% reduction in cumulative morphine consumption in both treatment groups at all time points up to 48 h after anaesthesia finished. The greatest reduction was from 12 h to 24 h which showed a 66% reduction for the SP group and a 55% reduction for the PS group compared to control (p = 0.0003 and 0.0049, respectively, with an adjusted significance value = 0.0167). For SP and PS groups, the time to first post-operative analgesic request tended to be longer and the number of patients requesting morphine in the recovery room was less. Conclusion: Parecoxib administration at the end of surgery is as effective as at the beginning with regard to analgesic and opioid-sparing effects. © 2008 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/acpainen_HK
dc.relation.ispartofAcute Painen_HK
dc.rightsAcute Pain. Copyright © Elsevier BV.en_HK
dc.subjectAnalgesiaen_HK
dc.subjectInflammationen_HK
dc.subjectParecoxiben_HK
dc.subjectSurgical injuryen_HK
dc.titleTiming of intraoperative parecoxib analgesia in colorectal surgeryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1366-0071&volume=10&spage=123&epage=130&date=2008&atitle=Timing+of+intraoperative+parecoxib+analgesia+in+colorectal+surgeryen_HK
dc.identifier.emailIrwin, MG: mgirwin@hku.hken_HK
dc.identifier.emailYao, TJ: tjyao@hkucc.hku.hken_HK
dc.identifier.emailCheung, CW: cheucw@hku.hken_HK
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.identifier.authorityYao, TJ=rp00284en_HK
dc.identifier.authorityCheung, CW=rp00244en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.acpain.2008.07.002en_HK
dc.identifier.scopuseid_2-s2.0-56249142724en_HK
dc.identifier.hkuros159857en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-56249142724&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue3-4en_HK
dc.identifier.spage123en_HK
dc.identifier.epage130en_HK
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLee, LH=24438121200en_HK
dc.identifier.scopusauthoridIrwin, MG=7202411076en_HK
dc.identifier.scopusauthoridYao, TJ=7401886444en_HK
dc.identifier.scopusauthoridYuen, MK=18042888000en_HK
dc.identifier.scopusauthoridCheung, CW=24754835800en_HK
dc.identifier.citeulike5332300-

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