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Article: Polysaccharopeptide mimics ciclosporin-mediated Th1/Th2 cytokine balance for suppression of activated human T cell proliferation by MAPKp38 and STAT5 pathways

TitlePolysaccharopeptide mimics ciclosporin-mediated Th1/Th2 cytokine balance for suppression of activated human T cell proliferation by MAPKp38 and STAT5 pathways
Authors
Issue Date2008
PublisherPharmaceutical Press. The Journal's web site is located at http://www.pharmpress.com/jpp
Citation
Journal Of Pharmacy And Pharmacology, 2008, v. 60 n. 11, p. 1491-1499 How to Cite?
AbstractThe activation of T helper (Th) cell subsets plays an important role in the human immune system. Uncontrolled Th1 and Th2 responses lead to autoimmune and inflammatory diseases, respectively. The identification of agents that modulate the Th1/Th2 cytokines is therefore essential for controlling these diseases. We recently reported that polysaccharopeptide (PSP) from Coriolus versicolor exhibited ciclosporin-like activities to control aberrant T lymphocyte activation. Here, we compared the properties of PSP with ciclosporin on cell proliferation, CD25 + expression, secretion of Th1/Th2 cytokines and activation of mitogen-activated protein kinase (MAPK)p38 and signal transducers and activators of transcription 5 (STAT5) on T cells. The data show that PSP alone suppresses the proliferation of activated T cells. PSP exhibited similar and additive inhibitory effects to ciclosporin to suppress activated T cell proliferation, Th1 cytokines and reduce CD3 +/CD25 + cell expression, but not Th2 cytokine expression, which helps the cytokine balance shift towards Th2 dominance. These suppressive actions of PSP involved the MAPKp38 and STAT5 pathways. These findings refine our understanding of the effects of PSP on T lymphocytes and its adjuvant properties with the immunosuppressant ciclosporin for possible control of autoimmune diseases. © 2008 The Authors.
Persistent Identifierhttp://hdl.handle.net/10722/60357
ISSN
2015 Impact Factor: 2.363
2015 SCImago Journal Rankings: 0.686
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong KongHKU 7511/03M
Hong Kong Association for Health Care Ltd, Hong Kong, SAR, P.R. China
Funding Information:

This work was supported in part by RGC Grant HKU 7511/03M obtained from The University of Hong Kong, and partially supported by the Hong Kong Association for Health Care Ltd, Hong Kong, SAR, P.R. China.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLee, CLen_HK
dc.contributor.authorSit, WHen_HK
dc.contributor.authorJiang, PPen_HK
dc.contributor.authorSo, IWYen_HK
dc.contributor.authorWan, JMFen_HK
dc.date.accessioned2010-05-31T04:09:02Z-
dc.date.available2010-05-31T04:09:02Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Pharmacy And Pharmacology, 2008, v. 60 n. 11, p. 1491-1499en_HK
dc.identifier.issn0022-3573en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60357-
dc.description.abstractThe activation of T helper (Th) cell subsets plays an important role in the human immune system. Uncontrolled Th1 and Th2 responses lead to autoimmune and inflammatory diseases, respectively. The identification of agents that modulate the Th1/Th2 cytokines is therefore essential for controlling these diseases. We recently reported that polysaccharopeptide (PSP) from Coriolus versicolor exhibited ciclosporin-like activities to control aberrant T lymphocyte activation. Here, we compared the properties of PSP with ciclosporin on cell proliferation, CD25 + expression, secretion of Th1/Th2 cytokines and activation of mitogen-activated protein kinase (MAPK)p38 and signal transducers and activators of transcription 5 (STAT5) on T cells. The data show that PSP alone suppresses the proliferation of activated T cells. PSP exhibited similar and additive inhibitory effects to ciclosporin to suppress activated T cell proliferation, Th1 cytokines and reduce CD3 +/CD25 + cell expression, but not Th2 cytokine expression, which helps the cytokine balance shift towards Th2 dominance. These suppressive actions of PSP involved the MAPKp38 and STAT5 pathways. These findings refine our understanding of the effects of PSP on T lymphocytes and its adjuvant properties with the immunosuppressant ciclosporin for possible control of autoimmune diseases. © 2008 The Authors.en_HK
dc.languageengen_HK
dc.publisherPharmaceutical Press. The Journal's web site is located at http://www.pharmpress.com/jppen_HK
dc.relation.ispartofJournal of Pharmacy and Pharmacologyen_HK
dc.titlePolysaccharopeptide mimics ciclosporin-mediated Th1/Th2 cytokine balance for suppression of activated human T cell proliferation by MAPKp38 and STAT5 pathwaysen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3573&volume=60&spage=1491&epage=1499&date=2008&atitle=Polysaccharopeptide+Mimics+Ciclosporin-mediated+Th1/th2+Cytokine+Balance+For+Suppression+Of+Activated+Human+T+Cell+Proliferation+By+Mapkp38+And+Stat5+Pathwaysen_HK
dc.identifier.emailWan, JMF: jmfwan@hku.hken_HK
dc.identifier.authorityWan, JMF=rp00798en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1211/jpp/60.11.0010en_HK
dc.identifier.pmid18957170-
dc.identifier.scopuseid_2-s2.0-54949084647en_HK
dc.identifier.hkuros154351en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-54949084647&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume60en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1491en_HK
dc.identifier.epage1499en_HK
dc.identifier.isiWOS:000260921500010-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectTo determine the mechanisms of apoptosis of polysaccharide peptide (PSP) in human leukemic cell lines and human normal lymphocytes-
dc.identifier.scopusauthoridLee, CL=9277221100en_HK
dc.identifier.scopusauthoridSit, WH=8528923000en_HK
dc.identifier.scopusauthoridJiang, PP=36147603700en_HK
dc.identifier.scopusauthoridSo, IWY=25628932800en_HK
dc.identifier.scopusauthoridWan, JMF=8930305000en_HK
dc.identifier.citeulike3426965-

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