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Article: Glycodelin in reproductive endocrinology and hormone-related cancer

TitleGlycodelin in reproductive endocrinology and hormone-related cancer
Authors
Issue Date2009
PublisherBioScientifica Ltd. The Journal's web site is located at http://www.eje-online.org/
Citation
European Journal Of Endocrinology, 2009, v. 160 n. 2, p. 121-133 How to Cite?
AbstractGlycodelin is an endocrine-regulated glycoprotein that has significant effects on immune cells, apoptosis, reproduction, cell adhesion, differentiation and cancer. In reproduction, glycodelin contributes to capacitation and immunoprotection of spermatozoa, and it modulates sperm-oocyte binding, acrosome reaction and implantation. In endocrine-related cancer, the differentiation inducing effects of glycodelin are accompanied by growth restriction of malignant cells, decreased expression of oncogenes, increased expression of tumour suppressor genes and morphological reversion of the malignant phenotype. This review features these properties and clinical connections, highlighting the role of glycosylation in biological actions. © 2009 European Society of Endocrinology.
Persistent Identifierhttp://hdl.handle.net/10722/60346
ISSN
2015 Impact Factor: 3.892
2015 SCImago Journal Rankings: 1.579
ISI Accession Number ID
Funding AgencyGrant Number
Helsinki University Central Hospital Research Fund
Research Grant Council, Hong KongHKU 7514/05M
HKU 7647/06M
Funding Information:

This work was supported by grants from the Helsinki University Central Hospital Research Fund and the Research Grant Council, Hong Kong (HKU 7514/05M and HKU 7647/06M).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorSeppälä, Men_HK
dc.contributor.authorKoistinen, Hen_HK
dc.contributor.authorKoistinen, Ren_HK
dc.contributor.authorHautala, Len_HK
dc.contributor.authorChiu, PCen_HK
dc.contributor.authorYeung, WSen_HK
dc.date.accessioned2010-05-31T04:08:48Z-
dc.date.available2010-05-31T04:08:48Z-
dc.date.issued2009en_HK
dc.identifier.citationEuropean Journal Of Endocrinology, 2009, v. 160 n. 2, p. 121-133en_HK
dc.identifier.issn0804-4643en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60346-
dc.description.abstractGlycodelin is an endocrine-regulated glycoprotein that has significant effects on immune cells, apoptosis, reproduction, cell adhesion, differentiation and cancer. In reproduction, glycodelin contributes to capacitation and immunoprotection of spermatozoa, and it modulates sperm-oocyte binding, acrosome reaction and implantation. In endocrine-related cancer, the differentiation inducing effects of glycodelin are accompanied by growth restriction of malignant cells, decreased expression of oncogenes, increased expression of tumour suppressor genes and morphological reversion of the malignant phenotype. This review features these properties and clinical connections, highlighting the role of glycosylation in biological actions. © 2009 European Society of Endocrinology.en_HK
dc.languageengen_HK
dc.publisherBioScientifica Ltd. The Journal's web site is located at http://www.eje-online.org/en_HK
dc.relation.ispartofEuropean Journal of Endocrinologyen_HK
dc.titleGlycodelin in reproductive endocrinology and hormone-related canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0804-4643&volume=160&spage=121&epage=133&date=2009&atitle=Glycodelin+in+reproductive+endocrinology+and+hormone-related+canceren_HK
dc.identifier.emailChiu, PC:pchiucn@hku.hken_HK
dc.identifier.emailYeung, WS:wsbyeung@hkucc.hku.hken_HK
dc.identifier.authorityChiu, PC=rp00424en_HK
dc.identifier.authorityYeung, WS=rp00331en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1530/EJE-08-0756en_HK
dc.identifier.pmid19039086-
dc.identifier.scopuseid_2-s2.0-61449200391en_HK
dc.identifier.hkuros158267en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-61449200391&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume160en_HK
dc.identifier.issue2en_HK
dc.identifier.spage121en_HK
dc.identifier.epage133en_HK
dc.identifier.isiWOS:000263355100001-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectRole of olfactomedin in implantation-
dc.relation.projectThe mechanism of action of a novel glycodelin isoform from cumulus matrix on stimulating spermatozoa-zona pellucida binding-
dc.identifier.scopusauthoridSeppälä, M=35475165300en_HK
dc.identifier.scopusauthoridKoistinen, H=7003612125en_HK
dc.identifier.scopusauthoridKoistinen, R=7006574669en_HK
dc.identifier.scopusauthoridHautala, L=18436947000en_HK
dc.identifier.scopusauthoridChiu, PC=25959969200en_HK
dc.identifier.scopusauthoridYeung, WS=7102370745en_HK
dc.identifier.citeulike3734573-

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