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Article: Modification by influenza on health effects of air pollution in Hong Kong

TitleModification by influenza on health effects of air pollution in Hong Kong
Authors
KeywordsAir pollution
Cardiorespiratory disease
Effect modification
Hospitalization
Influenza
Mortality
Issue Date2009
PublisherUS Department of Health and Human Services, National Institute of Environmental Health Sciences. The Journal's web site is located at http://ehp.niehs.nih.gov/
Citation
Environmental Health Perspectives, 2009, v. 117 n. 2, p. 248-253 How to Cite?
AbstractBackground: Both influenza viruses and air pollutants have been well documented as major hazards to human health, but few epidemiologic studies have assessed effect modification of influenza on health effects of ambient air pollutants. Objectives: We aimed to assess modifying effects of influenza on health effects of ambient air pollutants. Methods: We applied Poisson regression to daily numbers of hospitalizations and mortality to develop core models after adjustment for potential time-varying confounding variables. We assessed modification of influenza by adding variables for concentrations of single ambient air pollutants and proportions of influenza-positive specimens (influenza intensity) and their cross-product terms. Results: We found significant effect modification of influenza (p < 0.05) for effects of ozone. When influenza intensity is assumed to increase from 0% to 10%, the excess risks per 10-μg/m 3 increase in concentration of O 3 increased 0.24% and 0.40% for hospitalization of respiratory disease in the all-ages group and ≥ 65 year age group, respectively; 0.46% for hospitalization of acute respiratory disease in the all-ages group; and 0.40% for hospitalization of chronic obstructive pulmonary disease in the ≥ 65 group. The estimated increases in the excess risks for mortality of respiratory disease and chronic obstructive pulmonary disease in the all-ages group were 0.59% and 1.05%, respectively. We found no significant modification of influenza on effects of other pollutants in most disease outcomes under study. Conclusions: Influenza activity could be an effect modifier for the health effects of air pollutants particularly for O 3 and should be considered in the studies for short-term effects of air pollutants on health.
Persistent Identifierhttp://hdl.handle.net/10722/60328
ISSN
2015 Impact Factor: 8.443
2015 SCImago Journal Rankings: 3.529
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, CMen_HK
dc.contributor.authorYang, Len_HK
dc.contributor.authorThach, TQen_HK
dc.contributor.authorChau, PYKen_HK
dc.contributor.authorChan, KPen_HK
dc.contributor.authorThomas, GNen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorWong, TWen_HK
dc.contributor.authorHedley, AJen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.date.accessioned2010-05-31T04:08:22Z-
dc.date.available2010-05-31T04:08:22Z-
dc.date.issued2009en_HK
dc.identifier.citationEnvironmental Health Perspectives, 2009, v. 117 n. 2, p. 248-253en_HK
dc.identifier.issn0091-6765en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60328-
dc.description.abstractBackground: Both influenza viruses and air pollutants have been well documented as major hazards to human health, but few epidemiologic studies have assessed effect modification of influenza on health effects of ambient air pollutants. Objectives: We aimed to assess modifying effects of influenza on health effects of ambient air pollutants. Methods: We applied Poisson regression to daily numbers of hospitalizations and mortality to develop core models after adjustment for potential time-varying confounding variables. We assessed modification of influenza by adding variables for concentrations of single ambient air pollutants and proportions of influenza-positive specimens (influenza intensity) and their cross-product terms. Results: We found significant effect modification of influenza (p < 0.05) for effects of ozone. When influenza intensity is assumed to increase from 0% to 10%, the excess risks per 10-μg/m 3 increase in concentration of O 3 increased 0.24% and 0.40% for hospitalization of respiratory disease in the all-ages group and ≥ 65 year age group, respectively; 0.46% for hospitalization of acute respiratory disease in the all-ages group; and 0.40% for hospitalization of chronic obstructive pulmonary disease in the ≥ 65 group. The estimated increases in the excess risks for mortality of respiratory disease and chronic obstructive pulmonary disease in the all-ages group were 0.59% and 1.05%, respectively. We found no significant modification of influenza on effects of other pollutants in most disease outcomes under study. Conclusions: Influenza activity could be an effect modifier for the health effects of air pollutants particularly for O 3 and should be considered in the studies for short-term effects of air pollutants on health.en_HK
dc.languageengen_HK
dc.publisherUS Department of Health and Human Services, National Institute of Environmental Health Sciences. The Journal's web site is located at http://ehp.niehs.nih.gov/en_HK
dc.relation.ispartofEnvironmental Health Perspectivesen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAir pollutionen_HK
dc.subjectCardiorespiratory diseaseen_HK
dc.subjectEffect modificationen_HK
dc.subjectHospitalizationen_HK
dc.subjectInfluenzaen_HK
dc.subjectMortalityen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAir Pollution - adverse effectsen_HK
dc.subject.meshCardiovascular Diseases - mortalityen_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHospitalization - statistics & numerical dataen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfanten_HK
dc.subject.meshInfant, Newbornen_HK
dc.subject.meshInfluenza, Human - epidemiology - physiopathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOzone - toxicityen_HK
dc.subject.meshRegression Analysisen_HK
dc.subject.meshRespiration Disorders - mortalityen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshYoung Adulten_HK
dc.titleModification by influenza on health effects of air pollution in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0091-6765&volume=117&issue=2&spage=248&epage=253&date=2009&atitle=Modification+by+influenza+on+health+effects+of+air+pollution+in+Hong+Kongen_HK
dc.identifier.emailWong, CM: hrmrwcm@hku.hken_HK
dc.identifier.emailThach, TQ: thach@hku.hken_HK
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailHedley, AJ: hrmrajh@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authorityWong, CM=rp00338en_HK
dc.identifier.authorityThach, TQ=rp00450en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityHedley, AJ=rp00357en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1289/ehp.11605en_HK
dc.identifier.pmid19270795-
dc.identifier.pmcidPMC2649227-
dc.identifier.scopuseid_2-s2.0-60749090030en_HK
dc.identifier.hkuros154465en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-60749090030&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume117en_HK
dc.identifier.issue2en_HK
dc.identifier.spage248en_HK
dc.identifier.epage253en_HK
dc.identifier.eissn1552-9924-
dc.identifier.isiWOS:000262970700034-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, CM=7404954904en_HK
dc.identifier.scopusauthoridYang, L=7406279703en_HK
dc.identifier.scopusauthoridThach, TQ=6602850066en_HK
dc.identifier.scopusauthoridChau, PYK=34876162600en_HK
dc.identifier.scopusauthoridChan, KP=27171298000en_HK
dc.identifier.scopusauthoridThomas, GN=35465269900en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridWong, TW=7403531744en_HK
dc.identifier.scopusauthoridHedley, AJ=7102584095en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK

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