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Article: White blood cell count and the metabolic syndrome in older Chinese: The Guangzhou Biobank Cohort Study

TitleWhite blood cell count and the metabolic syndrome in older Chinese: The Guangzhou Biobank Cohort Study
Authors
Issue Date2008
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis
Citation
Atherosclerosis, 2008, v. 201 n. 2, p. 418-424 How to Cite?
AbstractAims: To examine the association between white blood cell count (WBC) and metabolic syndrome (MS) in an older Chinese population. Methods: Three thousand and twenty men and 7256 women aged 50-85 years were recruited and received a medical check-up including measurement of complete blood count, blood pressure, obesity indices, fasting total, LDL-, HDL-cholesterol, triglycerides, glucose and c-reactive protein (CRP). Information on socioeconomic and lifestyle factors was also collected. Results: Vascular risk factors including waist circumference, body mass index, triglyceride, total-, LDL-cholesterol, CRP and systolic and diastolic blood pressures were all positively associated with WBC in both men and women (p from 0.0085 to <0.001). The risk of MS increased significantly with higher total WBC, with adjusted odds ratios (95% confident interval) for second and third tertiles of 1.86 (1.43, 2.42), 2.56 (1.98, 3.32) in men and 1.67 (1.46, 1.90), 2.66 (2.34, 3.03) in women, respectively. Neutrophil and lymphocyte were strongly correlated with total WBC and showed similar association with the MS. Conclusion: There is a strong relationship between total WBC, neutrophil and lymphocyte and the constellation of MS components and associated vascular risk in this older Chinese population. © 2008 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/60310
ISSN
2015 Impact Factor: 3.942
2015 SCImago Journal Rankings: 1.819
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong Foundation for Educational Development and Research, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Bureau, Guangzhou, China
University of Birmingham, UK
Funding Information:

The study is funded by The University of Hong Kong Foundation for Educational Development and Research, Hong Kong; the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau, Guangzhou, China and The University of Birmingham, UK. The Guangzhou Biobank Cohort Study investigators include: the Guangzhou No. 12 Hospital: W.S. Zhang. M. Cao. T. Zhu. B. Liu. C.Q. Jiang (Co-PI) The University of Hong Kong: X.Q. Lao, C.M. Schooling, S.M. McGhee. R.F. Fielding, G.M. Leung, T.H. Lam (Co-PI): The University of Birmingham: G.N. Thomas, P. Adab, M. Zeegers. K.K. Cheno (Co-PI).

References

 

DC FieldValueLanguage
dc.contributor.authorLao, XQen_HK
dc.contributor.authorNeil Thomas, Gen_HK
dc.contributor.authorJiang, Cen_HK
dc.contributor.authorZhang, Wen_HK
dc.contributor.authorAdab, Pen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorCheng, KKen_HK
dc.date.accessioned2010-05-31T04:08:02Z-
dc.date.available2010-05-31T04:08:02Z-
dc.date.issued2008en_HK
dc.identifier.citationAtherosclerosis, 2008, v. 201 n. 2, p. 418-424en_HK
dc.identifier.issn0021-9150en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60310-
dc.description.abstractAims: To examine the association between white blood cell count (WBC) and metabolic syndrome (MS) in an older Chinese population. Methods: Three thousand and twenty men and 7256 women aged 50-85 years were recruited and received a medical check-up including measurement of complete blood count, blood pressure, obesity indices, fasting total, LDL-, HDL-cholesterol, triglycerides, glucose and c-reactive protein (CRP). Information on socioeconomic and lifestyle factors was also collected. Results: Vascular risk factors including waist circumference, body mass index, triglyceride, total-, LDL-cholesterol, CRP and systolic and diastolic blood pressures were all positively associated with WBC in both men and women (p from 0.0085 to <0.001). The risk of MS increased significantly with higher total WBC, with adjusted odds ratios (95% confident interval) for second and third tertiles of 1.86 (1.43, 2.42), 2.56 (1.98, 3.32) in men and 1.67 (1.46, 1.90), 2.66 (2.34, 3.03) in women, respectively. Neutrophil and lymphocyte were strongly correlated with total WBC and showed similar association with the MS. Conclusion: There is a strong relationship between total WBC, neutrophil and lymphocyte and the constellation of MS components and associated vascular risk in this older Chinese population. © 2008 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosisen_HK
dc.relation.ispartofAtherosclerosisen_HK
dc.rightsAtherosclerosis. Copyright © Elsevier Ireland Ltd.en_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshBlood Pressureen_HK
dc.subject.meshC-Reactive Protein - metabolismen_HK
dc.subject.meshChinaen_HK
dc.subject.meshCholesterol, HDL - metabolismen_HK
dc.subject.meshCholesterol, LDL - metabolismen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGlucose - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLeukocyte Counten_HK
dc.subject.meshMaleen_HK
dc.subject.meshMetabolic Syndrome X - blood - diagnosis - epidemiologyen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshObesityen_HK
dc.subject.meshTriglycerides - metabolismen_HK
dc.titleWhite blood cell count and the metabolic syndrome in older Chinese: The Guangzhou Biobank Cohort Studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9150&volume=201&spage=418&epage=424&date=2008&atitle=White+blood+cell+count+and+the+metabolic+syndrome+in+older+Chinese:+The+Guangzhou+Biobank+Cohort+Studyen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.atherosclerosis.2007.12.053en_HK
dc.identifier.pmid18295770-
dc.identifier.scopuseid_2-s2.0-49449086991en_HK
dc.identifier.hkuros153691en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-49449086991&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume201en_HK
dc.identifier.issue2en_HK
dc.identifier.spage418en_HK
dc.identifier.epage424en_HK
dc.identifier.isiWOS:000262050700025-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridLao, XQ=14031637000en_HK
dc.identifier.scopusauthoridNeil Thomas, G=23568357900en_HK
dc.identifier.scopusauthoridJiang, C=10639500500en_HK
dc.identifier.scopusauthoridZhang, W=36122238700en_HK
dc.identifier.scopusauthoridAdab, P=6601949045en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridCheng, KK=7402997800en_HK

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