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Article: Does cigarette smoking exacerbate the effect of total cholesterol and high-density lipoprotein cholesterol on the risk of cardiovascular diseases?

TitleDoes cigarette smoking exacerbate the effect of total cholesterol and high-density lipoprotein cholesterol on the risk of cardiovascular diseases?
Authors
Issue Date2009
PublisherB M J Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/
Citation
Heart, 2009, v. 95 n. 11, p. 909-916 How to Cite?
AbstractObjective: To explore whether an interaction between smoking and serum total cholesterol (TC) and/or decreased levels of serum high-density lipoprotein cholesterol (HDLC) exists for any major subtype of cardiovascular disease. Design: An individual participant overview of 34 cohort studies. Setting: The Asia-Pacific region. Participants: People aged ≥20 years without a particular condition or risk factor. Mean outcome measures: Hazard ratios (HRs) and 95% confidence intervals (CIs) for both TC and HDLC by smoking status were estimated using Cox proportional hazard models adjusted for age and systolic blood pressure and stratified by study and sex. Results: During follow-up (median 4.0 years), 3298 coronary heart disease (CHD) and 4318 stroke events were recorded. For CHD, the HR (95% CI) for an additional 1.06 mmol/l increment in TC was greater in current smokers than in non-smokers: 1.54 (1.43 to 1.66) versus 1.38 (1.30 to 1.47); p = 0.02. Similarly, the HR (95% CI) for an additional 0.40 mmol/l decrement in HDLC was greater in current smokers than in non-smokers: 1.67 (1.35 to 2.07) versus 1.28 (1.10 to 1.49); p = 0.04. The positive association of TC with ischaemic stroke, and the negative association of TC with haemorrhagic stroke, were broadly similar for current smokers and non-smokers. Similarly, the risks of both the subtypes of stroke remained broadly unchanged as HDLC decreased in both current smokers and non-smokers. Conclusions: Smoking exacerbated the effects of both TC and HDLC on CHD, although no interaction between smoking and TC or HDLC existed for either of the subtypes of stroke.
Persistent Identifierhttp://hdl.handle.net/10722/60298
ISSN
2015 Impact Factor: 5.693
2015 SCImago Journal Rankings: 2.647
ISI Accession Number ID
Funding AgencyGrant Number
National Health and Medical Research Council of Australia358395
Pfizer Inc.
Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of KoreaA040152
Funding Information:

This project has received support from a National Health and Medical Research Council of Australia programme grant (358395) and an unrestricted educational grant from Pfizer Inc. This study has been partially supported by a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (grant no A040152).

References

 

DC FieldValueLanguage
dc.contributor.authorNakamura, Ken_HK
dc.contributor.authorBarzi, Fen_HK
dc.contributor.authorHuxley, Ren_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorSuh, Ien_HK
dc.contributor.authorWoo, Jen_HK
dc.contributor.authorKim, HCen_HK
dc.contributor.authorFeigin, VLen_HK
dc.contributor.authorGu, Den_HK
dc.contributor.authorWoodward, Men_HK
dc.date.accessioned2010-05-31T04:07:48Z-
dc.date.available2010-05-31T04:07:48Z-
dc.date.issued2009en_HK
dc.identifier.citationHeart, 2009, v. 95 n. 11, p. 909-916en_HK
dc.identifier.issn1355-6037en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60298-
dc.description.abstractObjective: To explore whether an interaction between smoking and serum total cholesterol (TC) and/or decreased levels of serum high-density lipoprotein cholesterol (HDLC) exists for any major subtype of cardiovascular disease. Design: An individual participant overview of 34 cohort studies. Setting: The Asia-Pacific region. Participants: People aged ≥20 years without a particular condition or risk factor. Mean outcome measures: Hazard ratios (HRs) and 95% confidence intervals (CIs) for both TC and HDLC by smoking status were estimated using Cox proportional hazard models adjusted for age and systolic blood pressure and stratified by study and sex. Results: During follow-up (median 4.0 years), 3298 coronary heart disease (CHD) and 4318 stroke events were recorded. For CHD, the HR (95% CI) for an additional 1.06 mmol/l increment in TC was greater in current smokers than in non-smokers: 1.54 (1.43 to 1.66) versus 1.38 (1.30 to 1.47); p = 0.02. Similarly, the HR (95% CI) for an additional 0.40 mmol/l decrement in HDLC was greater in current smokers than in non-smokers: 1.67 (1.35 to 2.07) versus 1.28 (1.10 to 1.49); p = 0.04. The positive association of TC with ischaemic stroke, and the negative association of TC with haemorrhagic stroke, were broadly similar for current smokers and non-smokers. Similarly, the risks of both the subtypes of stroke remained broadly unchanged as HDLC decreased in both current smokers and non-smokers. Conclusions: Smoking exacerbated the effects of both TC and HDLC on CHD, although no interaction between smoking and TC or HDLC existed for either of the subtypes of stroke.en_HK
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/en_HK
dc.relation.ispartofHearten_HK
dc.rightsHeart. Copyright © B M J Publishing Group.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAsia - epidemiologyen_HK
dc.subject.meshCardiovascular Diseases - epidemiology - etiologyen_HK
dc.subject.meshCholesterol - blooden_HK
dc.subject.meshCholesterol, HDL - blooden_HK
dc.subject.meshEpidemiologic Methodsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPacific Islands - epidemiologyen_HK
dc.subject.meshSmoking - adverse effects - blood - epidemiologyen_HK
dc.subject.meshStroke - blood - epidemiology - etiologyen_HK
dc.subject.meshYoung Adulten_HK
dc.titleDoes cigarette smoking exacerbate the effect of total cholesterol and high-density lipoprotein cholesterol on the risk of cardiovascular diseases?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1355-6037&volume=95&issue=11&spage=909&epage=916&date=2009&atitle=Does+cigarette+smoking+exacerbate+the+effect+of+total+cholesterol+and+high-density+lipoprotein+cholesterol+on+the+risk+of+cardiovascular+diseases?en_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1136/hrt.2008.147066en_HK
dc.identifier.pmid19196734-
dc.identifier.scopuseid_2-s2.0-66549101965en_HK
dc.identifier.hkuros155679en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-66549101965&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume95en_HK
dc.identifier.issue11en_HK
dc.identifier.spage909en_HK
dc.identifier.epage916en_HK
dc.identifier.isiWOS:000266105600010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridNakamura, K=11139298500en_HK
dc.identifier.scopusauthoridBarzi, F=7003545543en_HK
dc.identifier.scopusauthoridHuxley, R=6701828350en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridSuh, I=7101988200en_HK
dc.identifier.scopusauthoridWoo, J=36040369400en_HK
dc.identifier.scopusauthoridKim, HC=8540942600en_HK
dc.identifier.scopusauthoridFeigin, VL=7005173210en_HK
dc.identifier.scopusauthoridGu, D=7202151958en_HK
dc.identifier.scopusauthoridWoodward, M=7102510958en_HK

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