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Article: Smoking, smoking cessation and inflammatory markers in older Chinese men: The Guangzhou Biobank Cohort Study

TitleSmoking, smoking cessation and inflammatory markers in older Chinese men: The Guangzhou Biobank Cohort Study
Authors
Issue Date2009
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosis
Citation
Atherosclerosis, 2009, v. 203 n. 1, p. 304-310 How to Cite?
AbstractAims: Smoking increases the risk of cardiovascular disease and inflammation plays a key role in the process of atherosclerosis. We therefore study the role of smoking and smoking cessation on the levels of inflammatory markers, C-reactive protein (CRP) and white blood cell (WBC) count, in older Chinese men. Methods: This cross-sectional analysis included 2999 men aged 50-85 years who received a medical check-up including measurement of fasting plasma vascular risk factors. Information on smoking status, socioeconomic and lifestyle factors was collected by standardized interview. Results: After adjustment for potential confounders, both CRP and WBC increased linearly across never, former and current smokers (both p < 0.01). The odds ratios of elevated CRP and WBC (upper tertiles) were also increased across never, former and current smokers (both p < 0.01). Dose-response relationships were observed among current smokers. Compared to current smokers, the odds ratios of elevated CRP and WBC and means of CRP and WBC declined with longer duration of smoking cessation (all p < 0.01). Conclusions: Smoking is associated with increased CRP and WBC levels, and smoking cessation is associated with the reduction of the increase, confirming the benefits of quitting. Inflammation may be a potential mechanism by which smoking promotes atherosclerotic disease. © 2008 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/60263
ISSN
2015 Impact Factor: 3.942
2015 SCImago Journal Rankings: 1.819
ISI Accession Number ID
Funding AgencyGrant Number
The University of Hong Kong Foundation for Educational Development and Research, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Bureau, Guangzhou, China
The University of Birmingham, UK
Funding Information:

The study is funded by The University of Hong Kong Foundation for Educational Development and Research, Hong Kong; the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau, Guangzhou, China; The University of Birmingham, UK. The Guangzhou Biobank Cohort Study investigators include: the Guangzhou No. 12 Hospital: W.S. Zhang, M. Cao, T. Zhu, B. Liu, C.Q. Jiang (Co-PI); The University of Hong Kong: X.Q. Lao, C.M. Schooling, S.M. McGhee, R. Fielding, G.M. Leung, T.H. Lam (Co-PI); The University of Birmingham: G.N. Thomas, P. Adab, M. Zeegers, K.K. Cheng (Co-PI).

References

 

DC FieldValueLanguage
dc.contributor.authorLao, XQen_HK
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorZhang, WSen_HK
dc.contributor.authorAdab, Pen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorCheng, KKen_HK
dc.contributor.authorThomas, GNen_HK
dc.date.accessioned2010-05-31T04:07:08Z-
dc.date.available2010-05-31T04:07:08Z-
dc.date.issued2009en_HK
dc.identifier.citationAtherosclerosis, 2009, v. 203 n. 1, p. 304-310en_HK
dc.identifier.issn0021-9150en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60263-
dc.description.abstractAims: Smoking increases the risk of cardiovascular disease and inflammation plays a key role in the process of atherosclerosis. We therefore study the role of smoking and smoking cessation on the levels of inflammatory markers, C-reactive protein (CRP) and white blood cell (WBC) count, in older Chinese men. Methods: This cross-sectional analysis included 2999 men aged 50-85 years who received a medical check-up including measurement of fasting plasma vascular risk factors. Information on smoking status, socioeconomic and lifestyle factors was collected by standardized interview. Results: After adjustment for potential confounders, both CRP and WBC increased linearly across never, former and current smokers (both p < 0.01). The odds ratios of elevated CRP and WBC (upper tertiles) were also increased across never, former and current smokers (both p < 0.01). Dose-response relationships were observed among current smokers. Compared to current smokers, the odds ratios of elevated CRP and WBC and means of CRP and WBC declined with longer duration of smoking cessation (all p < 0.01). Conclusions: Smoking is associated with increased CRP and WBC levels, and smoking cessation is associated with the reduction of the increase, confirming the benefits of quitting. Inflammation may be a potential mechanism by which smoking promotes atherosclerotic disease. © 2008 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/atherosclerosisen_HK
dc.relation.ispartofAtherosclerosisen_HK
dc.rightsAtherosclerosis. Copyright © Elsevier Ireland Ltd.en_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAtherosclerosis - ethnology - etiology - pathologyen_HK
dc.subject.meshC-Reactive Protein - biosynthesisen_HK
dc.subject.meshCardiovascular Diseases - ethnology - etiology - pathologyen_HK
dc.subject.meshChinaen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInflammation - blooden_HK
dc.subject.meshLeukocyte Counten_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshSmoking - adverse effectsen_HK
dc.subject.meshSmoking Cessationen_HK
dc.titleSmoking, smoking cessation and inflammatory markers in older Chinese men: The Guangzhou Biobank Cohort Studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9150&volume=203&issue=1&spage=304&epage=310&date=2009&atitle=Smoking,+smoking+cessation+and+inflammatory+markers+in+older+Chinese+men:+The+Guangzhou+Biobank+Cohort+Studyen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.atherosclerosis.2008.06.028en_HK
dc.identifier.pmid18692847-
dc.identifier.scopuseid_2-s2.0-60649108599en_HK
dc.identifier.hkuros154656en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-60649108599&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume203en_HK
dc.identifier.issue1en_HK
dc.identifier.spage304en_HK
dc.identifier.epage310en_HK
dc.identifier.isiWOS:000264510700046-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridLao, XQ=14031637000en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridZhang, WS=13410704100en_HK
dc.identifier.scopusauthoridAdab, P=6601949045en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridCheng, KK=7402997800en_HK
dc.identifier.scopusauthoridThomas, GN=35465269900en_HK

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