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Article: Acquisition of inverted GSTM exons by an intron of primate GSTM5 gene

TitleAcquisition of inverted GSTM exons by an intron of primate GSTM5 gene
Authors
KeywordsGSTM
Intronic stem loop
Inverted repeat
Primate
Issue Date2009
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhg/index.html
Citation
Journal Of Human Genetics, 2009, v. 54 n. 5, p. 271-276 How to Cite?
AbstractThe human GSTM gene family is composed of five gene members, GSTM1-5, and plays an important role in detoxification. In this study, the human GSTM5 gene was found to have a long inverted repeat (LIR) in intron 5. The LIR is able to form a stem-loop structure with a 31-bp stem and a 9-nt loop. The intronic LIR was also identified in other primates but not in non-primates. The human and chimpanzee LIRs had undergone compensating mutations that make the stem loop more stable, suggesting a functional role for the LIR. Sequence homology showed that the LIR was actually a part of inverted exons acquired by the intron. Results of phylogenetic analysis indicate that the inverted exons were derived from exon 5 of GSTM4 and exon 5 of GSTM1. The intronic LIR and inverted GSTM exons can probably introduce complexity in the expression of GSTM gene family. © 2009 The Japan Society of Human Genetics. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/60132
ISSN
2015 Impact Factor: 2.487
2015 SCImago Journal Rankings: 1.416
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Yen_HK
dc.contributor.authorLeung, FCCen_HK
dc.date.accessioned2010-05-31T04:04:17Z-
dc.date.available2010-05-31T04:04:17Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Human Genetics, 2009, v. 54 n. 5, p. 271-276en_HK
dc.identifier.issn1434-5161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60132-
dc.description.abstractThe human GSTM gene family is composed of five gene members, GSTM1-5, and plays an important role in detoxification. In this study, the human GSTM5 gene was found to have a long inverted repeat (LIR) in intron 5. The LIR is able to form a stem-loop structure with a 31-bp stem and a 9-nt loop. The intronic LIR was also identified in other primates but not in non-primates. The human and chimpanzee LIRs had undergone compensating mutations that make the stem loop more stable, suggesting a functional role for the LIR. Sequence homology showed that the LIR was actually a part of inverted exons acquired by the intron. Results of phylogenetic analysis indicate that the inverted exons were derived from exon 5 of GSTM4 and exon 5 of GSTM1. The intronic LIR and inverted GSTM exons can probably introduce complexity in the expression of GSTM gene family. © 2009 The Japan Society of Human Genetics. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhg/index.htmlen_HK
dc.relation.ispartofJournal of Human Geneticsen_HK
dc.subjectGSTMen_HK
dc.subjectIntronic stem loopen_HK
dc.subjectInverted repeaten_HK
dc.subjectPrimateen_HK
dc.titleAcquisition of inverted GSTM exons by an intron of primate GSTM5 geneen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1434-5161&volume=54&spage=271&epage=276&date=2009&atitle=Acquisition+Of+Inverted+Gstm+Exons+By+An+Intron+Of+Primate+Gstm5+Geneen_HK
dc.identifier.emailLeung, FCC: fcleung@hkucc.hku.hken_HK
dc.identifier.authorityLeung, FCC=rp00731en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/jhg.2009.23en_HK
dc.identifier.pmid19300457-
dc.identifier.scopuseid_2-s2.0-67649560892en_HK
dc.identifier.hkuros166171en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67649560892&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume54en_HK
dc.identifier.issue5en_HK
dc.identifier.spage271en_HK
dc.identifier.epage276en_HK
dc.identifier.isiWOS:000266538400004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWang, Y=7601487776en_HK
dc.identifier.scopusauthoridLeung, FCC=7103078633en_HK

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