File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Discovery of a long inverted repeat in human POTE genes

TitleDiscovery of a long inverted repeat in human POTE genes
Authors
KeywordsIntronic LIR
Phylogeny
POTE gene
Primates
Stem-loop
Issue Date2009
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygeno
Citation
Genomics, 2009, v. 94 n. 4, p. 278-283 How to Cite?
AbstractPOTE gene family is tightly related to prostate, ovary, testis and placenta cancers. We recently identified an intronic long inverted repeat (LIR) in some members of the POTE gene family. Due to the capacity of inducing gene amplification, the POTE intronic LIRs may be involved in over-expression of the POTE genes. Our study aimed to understand the origin of the LIR in primates. We collected the LIR and its flanking sequences within rhesus monkey, chimpanzee and human genomes. The rhesus monkey genome only has half-sized LIRs (lack one repeat copy), whereas the human and chimpanzee genomes contain both full-sized and half-sized LIRs. Phylogenetic tree indicates that the LIR is formed after divergence of rhesus monkey and the common ancestor of human and chimpanzee. The POTE genes containing a full-sized LIR were amplified in the human genome. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/60131
ISSN
2015 Impact Factor: 2.386
2015 SCImago Journal Rankings: 1.281
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Yen_HK
dc.contributor.authorLeung, FCCen_HK
dc.date.accessioned2010-05-31T04:04:12Z-
dc.date.available2010-05-31T04:04:12Z-
dc.date.issued2009en_HK
dc.identifier.citationGenomics, 2009, v. 94 n. 4, p. 278-283en_HK
dc.identifier.issn0888-7543en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60131-
dc.description.abstractPOTE gene family is tightly related to prostate, ovary, testis and placenta cancers. We recently identified an intronic long inverted repeat (LIR) in some members of the POTE gene family. Due to the capacity of inducing gene amplification, the POTE intronic LIRs may be involved in over-expression of the POTE genes. Our study aimed to understand the origin of the LIR in primates. We collected the LIR and its flanking sequences within rhesus monkey, chimpanzee and human genomes. The rhesus monkey genome only has half-sized LIRs (lack one repeat copy), whereas the human and chimpanzee genomes contain both full-sized and half-sized LIRs. Phylogenetic tree indicates that the LIR is formed after divergence of rhesus monkey and the common ancestor of human and chimpanzee. The POTE genes containing a full-sized LIR were amplified in the human genome. © 2009 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygenoen_HK
dc.relation.ispartofGenomicsen_HK
dc.subjectIntronic LIRen_HK
dc.subjectPhylogenyen_HK
dc.subjectPOTE geneen_HK
dc.subjectPrimatesen_HK
dc.subjectStem-loopen_HK
dc.subject.meshInverted Repeat Sequences-
dc.subject.meshOvary - metabolism-
dc.subject.meshPlacenta - metabolism-
dc.subject.meshProstate - metabolism-
dc.subject.meshTestis - metabolism-
dc.titleDiscovery of a long inverted repeat in human POTE genesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0888-7543&volume=94&issue=4&spage=278&epage=283&date=2009&atitle=Discovery+of+a+long+inverted+repeat+in+human+POTE+genesen_HK
dc.identifier.emailLeung, FCC: fcleung@hkucc.hku.hken_HK
dc.identifier.authorityLeung, FCC=rp00731en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ygeno.2009.05.005en_HK
dc.identifier.pmid19463943-
dc.identifier.scopuseid_2-s2.0-70249132116en_HK
dc.identifier.hkuros166186en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70249132116&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume94en_HK
dc.identifier.issue4en_HK
dc.identifier.spage278en_HK
dc.identifier.epage283en_HK
dc.identifier.isiWOS:000273387100009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWang, Y=8710320600en_HK
dc.identifier.scopusauthoridLeung, FCC=7103078633en_HK
dc.identifier.citeulike5179256-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats