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Article: Hepatocyte growth factor enhances proteolysis and invasiveness of human nasopharyngeal cancer cells through activation of PI3K and JNK

TitleHepatocyte growth factor enhances proteolysis and invasiveness of human nasopharyngeal cancer cells through activation of PI3K and JNK
Authors
KeywordsCell motility
Hepatocyte growth factor
Invasion
Met oncogene
Nasopharyngeal cancer
Signaling
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
Citation
Febs Letters, 2008, v. 582 n. 23-24, p. 3415-3422 How to Cite?
AbstractThe hepatocyte growth factor (HGF) receptor, Met, is frequently overexpressed in nasopharyngeal cancer (NPC). Here, we showed for the first time that human NPC cells with high Met expression were more sensitive to the cell motility and invasion effect of HGF. The downregulation of Met by small interfering RNA decreased tumor cell invasion/migration. HGF significantly increased matrix metalloproteinase-9 production. This was inhibited by blocking phosphatidylinositide 3-kinase (PI3K) and c-Jun N-terminal kinase (JNK), but not extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase signaling pathways. We also demonstrated that PI3K induced activation of JNK, with Akt as a potential point of this cross-talk. These results provide new insights into the molecular mechanism responsible for NPC progression and metastasis. © 2008 Federation of European Biochemical Societies.
Persistent Identifierhttp://hdl.handle.net/10722/59995
ISSN
2015 Impact Factor: 3.519
2015 SCImago Journal Rankings: 2.026
ISI Accession Number ID
Funding AgencyGrant Number
Committee on Research and Conference CouncilHKU 200607176117
200707176141
Funding Information:

This work was supported by the Committee on Research and Conference Council Grants HKU 200607176117 and 200707176141 (to A. S. T. Wong).

References

 

DC FieldValueLanguage
dc.contributor.authorZhou, HYen_HK
dc.contributor.authorWan, KFen_HK
dc.contributor.authorIp, CKMen_HK
dc.contributor.authorWong, CKCen_HK
dc.contributor.authorMak, NKen_HK
dc.contributor.authorLo, KWen_HK
dc.contributor.authorWong, ASTen_HK
dc.date.accessioned2010-05-31T04:01:44Z-
dc.date.available2010-05-31T04:01:44Z-
dc.date.issued2008en_HK
dc.identifier.citationFebs Letters, 2008, v. 582 n. 23-24, p. 3415-3422en_HK
dc.identifier.issn0014-5793en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59995-
dc.description.abstractThe hepatocyte growth factor (HGF) receptor, Met, is frequently overexpressed in nasopharyngeal cancer (NPC). Here, we showed for the first time that human NPC cells with high Met expression were more sensitive to the cell motility and invasion effect of HGF. The downregulation of Met by small interfering RNA decreased tumor cell invasion/migration. HGF significantly increased matrix metalloproteinase-9 production. This was inhibited by blocking phosphatidylinositide 3-kinase (PI3K) and c-Jun N-terminal kinase (JNK), but not extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase signaling pathways. We also demonstrated that PI3K induced activation of JNK, with Akt as a potential point of this cross-talk. These results provide new insights into the molecular mechanism responsible for NPC progression and metastasis. © 2008 Federation of European Biochemical Societies.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febsleten_HK
dc.relation.ispartofFEBS Lettersen_HK
dc.rightsF E B S Letters. Copyright © Elsevier BV.en_HK
dc.subjectCell motilityen_HK
dc.subjectHepatocyte growth factoren_HK
dc.subjectInvasionen_HK
dc.subjectMet oncogeneen_HK
dc.subjectNasopharyngeal canceren_HK
dc.subjectSignalingen_HK
dc.titleHepatocyte growth factor enhances proteolysis and invasiveness of human nasopharyngeal cancer cells through activation of PI3K and JNKen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-5793&volume=582&spage=3415&epage=3422&date=2008&atitle=Hepatocyte+growth+factor+enhances+proteolysis+and+invasiveness+of+human+nasopharyngeal+cancer+cells+through+activation+of+PI3K+and+JNKen_HK
dc.identifier.emailWong, AST: awong1@hkucc.hku.hken_HK
dc.identifier.authorityWong, AST=rp00805en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.febslet.2008.09.004en_HK
dc.identifier.pmid18789327-
dc.identifier.scopuseid_2-s2.0-53049106581en_HK
dc.identifier.hkuros158513en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-53049106581&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume582en_HK
dc.identifier.issue23-24en_HK
dc.identifier.spage3415en_HK
dc.identifier.epage3422en_HK
dc.identifier.isiWOS:000260806700028-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridZhou, HY=7404742310en_HK
dc.identifier.scopusauthoridWan, KF=24802394900en_HK
dc.identifier.scopusauthoridIp, CKM=23987652100en_HK
dc.identifier.scopusauthoridWong, CKC=35276549400en_HK
dc.identifier.scopusauthoridMak, NK=35587830100en_HK
dc.identifier.scopusauthoridLo, KW=7402101603en_HK
dc.identifier.scopusauthoridWong, AST=23987963300en_HK

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