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Article: Constitutive hypophosphorylation of extracellular signal-regulated kinases-1/2 and down-regulation of c-Jun in human gastric adenocarcinoma

TitleConstitutive hypophosphorylation of extracellular signal-regulated kinases-1/2 and down-regulation of c-Jun in human gastric adenocarcinoma
Authors
Keywordsc-Fos
c-Jun
Cyclooxygenase
Extracellular signal-regulated protein kinases
Gastric cancer
Issue Date2008
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2008, v. 373 n. 2, p. 330-334 How to Cite?
AbstractHyperphosphorylation of extracellular signal-regulated protein kinases-1/2 (ERK1/2) is known to promote cancer cell proliferation. We therefore investigated the constitutive phosphorylation levels of ERK1/2 and the expression of its downstream targets c-Fos, c-Jun, and cyclooxygenase-2 (COX-2) in biopsied human gastric cancer tissues. Results showed that ERK1/2 phosphorylation and c-Jun expression were significantly lowered in gastric cancer compared with the non-cancer adjacent tissues. The expression of c-Fos, however, was not altered while COX-2 was significantly up-regulated. To conclude, we demonstrate that hypophosphorylation of ERK1/2 may occur in gastric cancer. Such discovery may have implication in the application of pathway-directed therapy for this malignant disease. © 2008 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59984
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, WKKen_HK
dc.contributor.authorSung, JJYen_HK
dc.contributor.authorYu, Len_HK
dc.contributor.authorLi, ZJen_HK
dc.contributor.authorChu, KMen_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2010-05-31T04:01:23Z-
dc.date.available2010-05-31T04:01:23Z-
dc.date.issued2008en_HK
dc.identifier.citationBiochemical And Biophysical Research Communications, 2008, v. 373 n. 2, p. 330-334en_HK
dc.identifier.issn0006-291Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/59984-
dc.description.abstractHyperphosphorylation of extracellular signal-regulated protein kinases-1/2 (ERK1/2) is known to promote cancer cell proliferation. We therefore investigated the constitutive phosphorylation levels of ERK1/2 and the expression of its downstream targets c-Fos, c-Jun, and cyclooxygenase-2 (COX-2) in biopsied human gastric cancer tissues. Results showed that ERK1/2 phosphorylation and c-Jun expression were significantly lowered in gastric cancer compared with the non-cancer adjacent tissues. The expression of c-Fos, however, was not altered while COX-2 was significantly up-regulated. To conclude, we demonstrate that hypophosphorylation of ERK1/2 may occur in gastric cancer. Such discovery may have implication in the application of pathway-directed therapy for this malignant disease. © 2008 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_HK
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_HK
dc.subjectc-Fosen_HK
dc.subjectc-Junen_HK
dc.subjectCyclooxygenaseen_HK
dc.subjectExtracellular signal-regulated protein kinasesen_HK
dc.subjectGastric canceren_HK
dc.titleConstitutive hypophosphorylation of extracellular signal-regulated kinases-1/2 and down-regulation of c-Jun in human gastric adenocarcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-291X&volume=373&spage=330&epage=334&date=2008&atitle=Constitutive+hypophosphorylation+of+extracellular+signal-regulated+kinases-1/2+and+down-regulation+of+c-Jun+in+human+gastric+adenocarcinomaen_HK
dc.identifier.emailChu, KM: chukm@hkucc.hku.hken_HK
dc.identifier.authorityChu, KM=rp00435en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbrc.2008.06.025en_HK
dc.identifier.pmid18570890-
dc.identifier.scopuseid_2-s2.0-46049105896en_HK
dc.identifier.hkuros149171en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-46049105896&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume373en_HK
dc.identifier.issue2en_HK
dc.identifier.spage330en_HK
dc.identifier.epage334en_HK
dc.identifier.isiWOS:000257758700028-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWu, WKK=18345422600en_HK
dc.identifier.scopusauthoridSung, JJY=36847007100en_HK
dc.identifier.scopusauthoridYu, L=7404164696en_HK
dc.identifier.scopusauthoridLi, ZJ=35170171500en_HK
dc.identifier.scopusauthoridChu, KM=7402453538en_HK
dc.identifier.scopusauthoridCho, CH=14067000400en_HK

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