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Article: Outcome of craniofacial surgery in children and adolescents with malignant tumors involving the skull base: An international collaborative study

TitleOutcome of craniofacial surgery in children and adolescents with malignant tumors involving the skull base: An international collaborative study
Authors
KeywordsCancer
Children
Cranial base
Malignant tumors
Pediatric tumors
Sarcomas
Skull base
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137
Citation
Head And Neck, 2009, v. 31 n. 3, p. 308-317 How to Cite?
AbstractBackground. The aim of the study was to characterize the distribution of anterior skull base (ASB) cancers in the pediatric population and to identify predictors of outcome. Methods. This was an international study of 1307 patients undergoing craniofacial surgery for malignant tumors; 6.4% (n = 84) among these were ≤21 years old. Results. The most common histologic type was sarcoma (40%), followed by squamous cell carcinoma (14%). Higher incidence of tumors was found in older children (7.5-21 years) compared to younger children. The 5-year disease-specific and overall survival rates were 61% and 55%, respectively (median follow-up of 30 months). The best prognosis was associated with low-grade sarcomas and the worst with salivary and squamous cell carcinomas. High-grade sarcoma represented an intermediate risk group. On multivariate analysis, prior radiotherapy and histology were independent predictors of survival. Conclusion. Surgery for malignant tumors involving the ASB is feasible and safe in children. Histology is significant determinant of poor outcome in this population. © 2008 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/59979
ISSN
2015 Impact Factor: 2.76
2015 SCImago Journal Rankings: 1.233
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGil, Zen_HK
dc.contributor.authorPatel, SGen_HK
dc.contributor.authorCantu, Gen_HK
dc.contributor.authorFliss, DMen_HK
dc.contributor.authorKowalski, LPen_HK
dc.contributor.authorSingh, Ben_HK
dc.contributor.authorSnyderman, Cen_HK
dc.contributor.authorKraus, DHen_HK
dc.contributor.authorShah, JPen_HK
dc.contributor.authorBridger, PGen_HK
dc.contributor.authorCheesman, ADen_HK
dc.contributor.authorDonald, Pen_HK
dc.contributor.authorGullane, Pen_HK
dc.contributor.authorJanecka, Ien_HK
dc.contributor.authorKamata, SEen_HK
dc.contributor.authorLevine, PAen_HK
dc.contributor.authorMedina, LRen_HK
dc.contributor.authorPradhan, Sen_HK
dc.contributor.authorSchramm, Ven_HK
dc.contributor.authorWei, WIen_HK
dc.date.accessioned2010-05-31T04:01:18Z-
dc.date.available2010-05-31T04:01:18Z-
dc.date.issued2009en_HK
dc.identifier.citationHead And Neck, 2009, v. 31 n. 3, p. 308-317en_HK
dc.identifier.issn1043-3074en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59979-
dc.description.abstractBackground. The aim of the study was to characterize the distribution of anterior skull base (ASB) cancers in the pediatric population and to identify predictors of outcome. Methods. This was an international study of 1307 patients undergoing craniofacial surgery for malignant tumors; 6.4% (n = 84) among these were ≤21 years old. Results. The most common histologic type was sarcoma (40%), followed by squamous cell carcinoma (14%). Higher incidence of tumors was found in older children (7.5-21 years) compared to younger children. The 5-year disease-specific and overall survival rates were 61% and 55%, respectively (median follow-up of 30 months). The best prognosis was associated with low-grade sarcomas and the worst with salivary and squamous cell carcinomas. High-grade sarcoma represented an intermediate risk group. On multivariate analysis, prior radiotherapy and histology were independent predictors of survival. Conclusion. Surgery for malignant tumors involving the ASB is feasible and safe in children. Histology is significant determinant of poor outcome in this population. © 2008 Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137en_HK
dc.relation.ispartofHead and Necken_HK
dc.rightsHead & Neck. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectCanceren_HK
dc.subjectChildrenen_HK
dc.subjectCranial baseen_HK
dc.subjectMalignant tumorsen_HK
dc.subjectPediatric tumorsen_HK
dc.subjectSarcomasen_HK
dc.subjectSkull baseen_HK
dc.titleOutcome of craniofacial surgery in children and adolescents with malignant tumors involving the skull base: An international collaborative studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1043-3074&volume=31&spage=308&epage=17&date=2009&atitle=Outcome+of+craniofacial+surgery+in+children+and+adolescents+with+malignant+tumors+involving+the+skull+base:+an+international+collaborative+studyen_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hed.20958en_HK
dc.identifier.pmid19073003-
dc.identifier.scopuseid_2-s2.0-62249202085en_HK
dc.identifier.hkuros154664en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-62249202085&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue3en_HK
dc.identifier.spage308en_HK
dc.identifier.epage317en_HK
dc.identifier.isiWOS:000264011500004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGil, Z=26643270700en_HK
dc.identifier.scopusauthoridPatel, SG=7403903141en_HK
dc.identifier.scopusauthoridCantu, G=7003498793en_HK
dc.identifier.scopusauthoridFliss, DM=7005455625en_HK
dc.identifier.scopusauthoridKowalski, LP=7102126040en_HK
dc.identifier.scopusauthoridSingh, B=7405639360en_HK
dc.identifier.scopusauthoridSnyderman, C=7005989580en_HK
dc.identifier.scopusauthoridKraus, DH=25947461900en_HK
dc.identifier.scopusauthoridShah, JP=7403266008en_HK
dc.identifier.scopusauthoridBridger, PG=6603845621en_HK
dc.identifier.scopusauthoridCheesman, AD=7003676128en_HK
dc.identifier.scopusauthoridDonald, P=7103189603en_HK
dc.identifier.scopusauthoridGullane, P=7005484642en_HK
dc.identifier.scopusauthoridJanecka, I=7005569375en_HK
dc.identifier.scopusauthoridKamata, SE=35478208000en_HK
dc.identifier.scopusauthoridLevine, PA=35386674700en_HK
dc.identifier.scopusauthoridMedina, LR=8581762500en_HK
dc.identifier.scopusauthoridPradhan, S=7202877432en_HK
dc.identifier.scopusauthoridSchramm, V=35511790400en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK

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