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Article: Testicular cell junction: A novel target for male contraception

TitleTesticular cell junction: A novel target for male contraception
Authors
KeywordsBlood-testis barrier
Cell junctions
Male contraception
Sertoli-germ cell interactions
Spermatogenesis
Testis
Issue Date2009
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cmc/index.htm
Citation
Current Medicinal Chemistry, 2009, v. 16 n. 7, p. 906-915 How to Cite?
AbstractEven though various contraceptive methods are widely available, the number of unwanted pregnancies is still on the rise in developing countries, pressurizing the already resource limited nations. One of the major underlying reasons is the lack of effective, low cost, and safe contraceptives for couples. During the past decade, some studies were performed using animal models to decipher if the Sertoli-germ cell junction in the testis is a target for male fertility regulation. Some of these study models were based on the use of hormones and/or chemicals to disrupt the hypothalamicpituitary-testicular axis (e.g., androgen-based implants or pills) and others utilized a panel of chemical entities or synthetic peptides to perturb spermatogenesis either reversibly or non-reversibly. Among them, adjudin, a potential male contraceptive, is one of the compounds exerting its action on the unique adherens junctions, known as ectoplasmic specializations, in the testis. Since the testis is equipped with inter-connected cell junctions, an initial targeting of one junction type may affect the others and these accumulative effects could lead to spermatogenic arrest. This review attempts to cover an innovative theme on how male infertility can be achieved by inducing junction instability and defects in the testis, opening a new window of research for male contraceptive development. While it will still take much time and effort of intensive investigation before a product can reach the consumable market, these findings have provided hope for better family planning involving men. © 2009 Bentham Science Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/59937
ISSN
2015 Impact Factor: 3.455
2015 SCImago Journal Rankings: 0.842
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, NPYen_HK
dc.contributor.authorWong, EWPen_HK
dc.contributor.authorMruk, DDen_HK
dc.contributor.authorCheng, CYen_HK
dc.date.accessioned2010-05-31T04:00:30Z-
dc.date.available2010-05-31T04:00:30Z-
dc.date.issued2009en_HK
dc.identifier.citationCurrent Medicinal Chemistry, 2009, v. 16 n. 7, p. 906-915en_HK
dc.identifier.issn0929-8673en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59937-
dc.description.abstractEven though various contraceptive methods are widely available, the number of unwanted pregnancies is still on the rise in developing countries, pressurizing the already resource limited nations. One of the major underlying reasons is the lack of effective, low cost, and safe contraceptives for couples. During the past decade, some studies were performed using animal models to decipher if the Sertoli-germ cell junction in the testis is a target for male fertility regulation. Some of these study models were based on the use of hormones and/or chemicals to disrupt the hypothalamicpituitary-testicular axis (e.g., androgen-based implants or pills) and others utilized a panel of chemical entities or synthetic peptides to perturb spermatogenesis either reversibly or non-reversibly. Among them, adjudin, a potential male contraceptive, is one of the compounds exerting its action on the unique adherens junctions, known as ectoplasmic specializations, in the testis. Since the testis is equipped with inter-connected cell junctions, an initial targeting of one junction type may affect the others and these accumulative effects could lead to spermatogenic arrest. This review attempts to cover an innovative theme on how male infertility can be achieved by inducing junction instability and defects in the testis, opening a new window of research for male contraceptive development. While it will still take much time and effort of intensive investigation before a product can reach the consumable market, these findings have provided hope for better family planning involving men. © 2009 Bentham Science Publishers Ltd.en_HK
dc.languageengen_HK
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cmc/index.htmen_HK
dc.relation.ispartofCurrent Medicinal Chemistryen_HK
dc.subjectBlood-testis barrieren_HK
dc.subjectCell junctionsen_HK
dc.subjectMale contraceptionen_HK
dc.subjectSertoli-germ cell interactionsen_HK
dc.subjectSpermatogenesisen_HK
dc.subjectTestisen_HK
dc.titleTesticular cell junction: A novel target for male contraceptionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0929-8673&volume=16&issue=7&spage=906&epage=915&date=2009&atitle=Testicular+cell+junction:+a+novel+target+for+male+contraceptionen_HK
dc.identifier.emailLee, NPY: nikkilee@hku.hken_HK
dc.identifier.authorityLee, NPY=rp00263en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.2174/092986709787549262en_HK
dc.identifier.pmid19275601en_HK
dc.identifier.scopuseid_2-s2.0-65649131950en_HK
dc.identifier.hkuros165250en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-65649131950&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue7en_HK
dc.identifier.spage906en_HK
dc.identifier.epage915en_HK
dc.identifier.isiWOS:000265691500007-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLee, NPY=7402722690en_HK
dc.identifier.scopusauthoridWong, EWP=23029194700en_HK
dc.identifier.scopusauthoridMruk, DD=6701823934en_HK
dc.identifier.scopusauthoridCheng, CY=7404797787en_HK
dc.identifier.citeulike4121563-

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