Conference Paper: Role of branched-chain amino acids in management of cirrhosis and hepatocellular carcinoma

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TitleRole of branched-chain amino acids in management of cirrhosis and hepatocellular carcinoma
AuthorsLam, VW1 2
Poon, RT2
KeywordsBranched-chain amino acids
Cirrhosis
Hepatic encephalopathy
Hepatocellular carcinoma
Liver transplantation
Issue Date2008
PublisherBlackwell Publishing Ltd
CitationHepatology Research, 2008, v. 38 SUPPL. 1, p. S107-S115 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1872-034X.2008.00435.x
AbstractAltered protein and energy metabolism is a hallmark of chronic liver disease, characterized by decreased plasma branched-chain amino acids (BCAA) and increased plasma aromatic amino acids (AAA). Overwhelming evidence has indicated that the incidence of complications of chronic liver disease increases with malnutrition. Hence nutritional management in patients with chronic liver disease must receive high priority. The use of BCAA supplementation has been a controversial subject. This review summarizes published results of BCAA supplementation as a nutritional therapy for patients with cirrhosis and hepatocellular carcinoma (HCC). On balance, it would be appropriate to conclude that BCAA are associated with decreased frequency of complications of cirrhosis and improved nutritional status when prescribed as a maintenance therapy for patients with cirrhosis. More studies are, however, required to identify those who might benefit most from BCAA supplementation. © 2008 The Japan Society of Hepatology.
ISSN1386-6346
2011 Impact Factor: 2.199
2011 SCImago Journal Rankings: 0.193
DOIhttp://dx.doi.org/10.1111/j.1872-034X.2008.00435.x
ISI Accession Number IDWOS:000261713100019
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLam, VW
dc.contributor.authorPoon, RT
dc.date.accessioned2010-05-31T04:00:19Z
dc.date.available2010-05-31T04:00:19Z
dc.date.issued2008
dc.description.abstractAltered protein and energy metabolism is a hallmark of chronic liver disease, characterized by decreased plasma branched-chain amino acids (BCAA) and increased plasma aromatic amino acids (AAA). Overwhelming evidence has indicated that the incidence of complications of chronic liver disease increases with malnutrition. Hence nutritional management in patients with chronic liver disease must receive high priority. The use of BCAA supplementation has been a controversial subject. This review summarizes published results of BCAA supplementation as a nutritional therapy for patients with cirrhosis and hepatocellular carcinoma (HCC). On balance, it would be appropriate to conclude that BCAA are associated with decreased frequency of complications of cirrhosis and improved nutritional status when prescribed as a maintenance therapy for patients with cirrhosis. More studies are, however, required to identify those who might benefit most from BCAA supplementation. © 2008 The Japan Society of Hepatology.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationHepatology Research, 2008, v. 38 SUPPL. 1, p. S107-S115 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1872-034X.2008.00435.x
dc.identifier.doihttp://dx.doi.org/10.1111/j.1872-034X.2008.00435.x
dc.identifier.epageS115
dc.identifier.hkuros167036
dc.identifier.isiWOS:000261713100019
dc.identifier.issn1386-6346
2011 Impact Factor: 2.199
2011 SCImago Journal Rankings: 0.193
dc.identifier.issueSUPPL. 1
dc.identifier.openurl
dc.identifier.scopuseid_2-s2.0-58049084242
dc.identifier.spageS107
dc.identifier.urihttp://hdl.handle.net/10722/59928
dc.identifier.volume38
dc.languageeng
dc.publisherBlackwell Publishing Ltd
dc.publisher.placeIreland
dc.relation.ispartofHepatology Research
dc.relation.referencesReferences in Scopus
dc.rightsHepatology Research. Copyright © Blackwell Publishing Ltd.
dc.subjectBranched-chain amino acids
dc.subjectCirrhosis
dc.subjectHepatic encephalopathy
dc.subjectHepatocellular carcinoma
dc.subjectLiver transplantation
dc.titleRole of branched-chain amino acids in management of cirrhosis and hepatocellular carcinoma
dc.typeConference_Paper
Author Affiliations
  1. University of Sydney
  2. The University of Hong Kong