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Article: Heat shock proteins in cancer: Signaling pathways, tumor markers and molecular targets in liver malignancy

TitleHeat shock proteins in cancer: Signaling pathways, tumor markers and molecular targets in liver malignancy
Authors
KeywordsDiagnostic biomarkers
Heat shock protein
Hepatocellular carcinoma
Therapeutic targets
Issue Date2009
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/ppl/index.htm
Citation
Protein And Peptide Letters, 2009, v. 16 n. 5, p. 508-516 How to Cite?
AbstractHeat shock proteins (HSPs) consist of a large group of proteins with negligible expressions under physiological conditions. Their expressions are highly induced under stress conditions and they are ubiquitously expressed in various tissues and organs. HSPs possess chaperone functions, thus facilitating the correct folding of proteins or peptides. In hepatocellular carcinoma (HCC), high expressions of HSPs are demonstrated in liver cancer tissues and are correlated clinically with the severity of tumors and poor outcomes of HCC patients. This property enables them to be used as diagnostic markers for the onset of HCC. Since their expressions are highly expressed in liver cancer conditions, inhibitors or an- tisense oligonucleotides of HSPs are postulated to serve as potential therapeutics in treating this liver malignancy. In this review, we will first introduce the HSP family and discuss the major signaling pathways involved for the activities of HSPs. In addition, the clinical applications of HSPs in liver cancer in the aspects of diagnosis and therapy will be summarized and discussed. © 2009 Bentham Science Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/59926
ISSN
2015 Impact Factor: 1.069
2015 SCImago Journal Rankings: 0.472
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLu, WJen_HK
dc.contributor.authorLee, NPen_HK
dc.contributor.authorFatima, Sen_HK
dc.contributor.authorLuk, JMen_HK
dc.date.accessioned2010-05-31T04:00:17Z-
dc.date.available2010-05-31T04:00:17Z-
dc.date.issued2009en_HK
dc.identifier.citationProtein And Peptide Letters, 2009, v. 16 n. 5, p. 508-516en_HK
dc.identifier.issn0929-8665en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59926-
dc.description.abstractHeat shock proteins (HSPs) consist of a large group of proteins with negligible expressions under physiological conditions. Their expressions are highly induced under stress conditions and they are ubiquitously expressed in various tissues and organs. HSPs possess chaperone functions, thus facilitating the correct folding of proteins or peptides. In hepatocellular carcinoma (HCC), high expressions of HSPs are demonstrated in liver cancer tissues and are correlated clinically with the severity of tumors and poor outcomes of HCC patients. This property enables them to be used as diagnostic markers for the onset of HCC. Since their expressions are highly expressed in liver cancer conditions, inhibitors or an- tisense oligonucleotides of HSPs are postulated to serve as potential therapeutics in treating this liver malignancy. In this review, we will first introduce the HSP family and discuss the major signaling pathways involved for the activities of HSPs. In addition, the clinical applications of HSPs in liver cancer in the aspects of diagnosis and therapy will be summarized and discussed. © 2009 Bentham Science Publishers Ltd.en_HK
dc.languageengen_HK
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/ppl/index.htmen_HK
dc.relation.ispartofProtein and Peptide Lettersen_HK
dc.subjectDiagnostic biomarkersen_HK
dc.subjectHeat shock proteinen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectTherapeutic targetsen_HK
dc.titleHeat shock proteins in cancer: Signaling pathways, tumor markers and molecular targets in liver malignancyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0929-8665&volume=16&issue=5&spage=508&epage=516&date=2009&atitle=Heat+shock+proteins+in+cancer:+signaling+pathways,+tumor+markers+and+molecular+targets+in+liver+malignancyen_HK
dc.identifier.emailLee, NP: nikkilee@hku.hken_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityLee, NP=rp00263en_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2174/092986609788167752en_HK
dc.identifier.pmid19442230-
dc.identifier.scopuseid_2-s2.0-67649352512en_HK
dc.identifier.hkuros165225en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67649352512&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue5en_HK
dc.identifier.spage508en_HK
dc.identifier.epage516en_HK
dc.identifier.isiWOS:000265799400009-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLu, WJ=35187521100en_HK
dc.identifier.scopusauthoridLee, NP=7402722690en_HK
dc.identifier.scopusauthoridFatima, S=8437472300en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK
dc.identifier.citeulike4447211-

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