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Article: Correlation and familial aggregation of dimensions of psychosis in affected sibling pairs from China

TitleCorrelation and familial aggregation of dimensions of psychosis in affected sibling pairs from China
Authors
Issue Date2008
PublisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/
Citation
British Journal Of Psychiatry, 2008, v. 193 n. 4, p. 305-310 How to Cite?
AbstractBackground A number of studies with conflicting results have examined the familiality of schizophrenia syndromes in Western populations. Aims The objective of this study was to determine, using clinical data from concordant sibling pairs, whether symptom dimensions and other clinical characteristics of schizophrenia show familial aggregation and are therefore potentially useful traits in genetic studies. Method We measured clinical and demographic features, and symptom dimensions of schizophrenia in 137 families from China who had two or more affected members with schizophrenia. Within-sibling pair correlation was assessed with intraclass correlation coefficient and kappa statistics. Results Global functioning, positive, disorganisation and dysphoric symptoms, premorbid schizotypal and schizoid traits, premorbid social adjustment, type and age at illness onset all showed significant evidence of familial aggregation. DSM-IV schizophrenia subtypes were also found to be familial. Conclusions This is the first study in a large non-European population to confirm that schizophrenia dimensions and clinical characteristics show significant familiality, implying possible heritability. This supports their use in the delineation of homogeneous subsets for future genetic studies. Declaration of interest None. Funding detailed in Acknowledgements.
Persistent Identifierhttp://hdl.handle.net/10722/59738
ISSN
2015 Impact Factor: 7.06
2015 SCImago Journal Rankings: 2.674
ISI Accession Number ID
Funding AgencyGrant Number
National Nature Science Foundation of China30530300
30125014
NARSAD Independent Investigator Award
Wellcome Trust
National Basic Research Program of China2007CB512301
European Commission
State Scholarship Foundation of Greece
Funding Information:

This work was partly funded by the National Nature Science Foundation of China (30530300 and 30125014) (T.L.), NARSAD Independent Investigator Award (T.L.), the Wellcome Trust (International Collaborative award to T.L., D.A.C., X.S. and X.L.), the National Basic Research Program of China (973 Program 2007CB512301) (T.L.), European Commission (SGENE) (D.A.C., E.M., T.L.) and the State Scholarship Foundation of Greece (E.V.).

References

 

DC FieldValueLanguage
dc.contributor.authorVassos, Een_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorCai, Gen_HK
dc.contributor.authorDeng, Hen_HK
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorSun, Xen_HK
dc.contributor.authorZhao, Jen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorCollier, DAen_HK
dc.contributor.authorLi, Ten_HK
dc.date.accessioned2010-05-31T03:56:24Z-
dc.date.available2010-05-31T03:56:24Z-
dc.date.issued2008en_HK
dc.identifier.citationBritish Journal Of Psychiatry, 2008, v. 193 n. 4, p. 305-310en_HK
dc.identifier.issn0007-1250en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59738-
dc.description.abstractBackground A number of studies with conflicting results have examined the familiality of schizophrenia syndromes in Western populations. Aims The objective of this study was to determine, using clinical data from concordant sibling pairs, whether symptom dimensions and other clinical characteristics of schizophrenia show familial aggregation and are therefore potentially useful traits in genetic studies. Method We measured clinical and demographic features, and symptom dimensions of schizophrenia in 137 families from China who had two or more affected members with schizophrenia. Within-sibling pair correlation was assessed with intraclass correlation coefficient and kappa statistics. Results Global functioning, positive, disorganisation and dysphoric symptoms, premorbid schizotypal and schizoid traits, premorbid social adjustment, type and age at illness onset all showed significant evidence of familial aggregation. DSM-IV schizophrenia subtypes were also found to be familial. Conclusions This is the first study in a large non-European population to confirm that schizophrenia dimensions and clinical characteristics show significant familiality, implying possible heritability. This supports their use in the delineation of homogeneous subsets for future genetic studies. Declaration of interest None. Funding detailed in Acknowledgements.en_HK
dc.languageengen_HK
dc.publisherRoyal College of Psychiatrists. The Journal's web site is located at http://bjp.rcpsych.org/en_HK
dc.relation.ispartofBritish Journal of Psychiatryen_HK
dc.titleCorrelation and familial aggregation of dimensions of psychosis in affected sibling pairs from Chinaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1250&volume=193&spage=305&epage=310&date=2008&atitle=Correlation+and+familial+aggregation+of+dimensions+of+psychosis+in+affected+sibling+pairs+from+Chinaen_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1192/bjp.bp.107.046037en_HK
dc.identifier.pmid18827292-
dc.identifier.scopuseid_2-s2.0-53949089631en_HK
dc.identifier.hkuros158074en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-53949089631&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume193en_HK
dc.identifier.issue4en_HK
dc.identifier.spage305en_HK
dc.identifier.epage310en_HK
dc.identifier.isiWOS:000260285000007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridVassos, E=35369293900en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridCai, G=15134875600en_HK
dc.identifier.scopusauthoridDeng, H=35204671600en_HK
dc.identifier.scopusauthoridLiu, X=7409286408en_HK
dc.identifier.scopusauthoridSun, X=7405624871en_HK
dc.identifier.scopusauthoridZhao, J=7410311266en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridCollier, DA=26642980600en_HK
dc.identifier.scopusauthoridLi, T=36072008200en_HK

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