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Article: Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins

TitleGenetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins
Authors
KeywordsBMI
Genes
Height
Population group
Twins
Weight
Issue Date2008
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ijo/
Citation
International Journal Of Obesity, 2008, v. 32 n. 10, p. 1455-1467 How to Cite?
AbstractObjective: Twin studies are useful for investigating the causes of trait variation between as well as within a population. The goals of the present study were two-fold: First, we aimed to compare the total phenotypic, genetic and environmental variances of height, weight and BMI between Caucasians and East Asians using twins. Secondly, we intended to estimate the extent to which genetic and environmental factors contribute to differences in variability of height, weight and BMI between Caucasians and East Asians. Design: Height and weight data from 3735 Caucasian and 1584 East Asian twin pairs (age: 13-15 years) from Australia, China, Finland, Japan, the Netherlands, South Korea, Taiwan and the United States were used for analyses. Maximum likelihood twin correlations and variance components model-fitting analyses were conducted to fulfill the goals of the present study. Results: The absolute genetic variances for height, weight and BMI were consistently greater in Caucasians than in East Asians with corresponding differences in total variances for all three body measures. In all 80 to 100% of the differences in total variances of height, weight and BMI between the two population groups were associated with genetic differences. Conclusion: Height, weight and BMI were more variable in Caucasian than in East Asian adolescents. Genetic variances for these three body measures were also larger in Caucasians than in East Asians. Variance components model-fitting analyses indicated that genetic factors contributed to the difference in variability of height, weight and BMI between the two population groups. Association studies for these body measures should take account of our findings of differences in genetic variances between the two population groups. © 2008 Macmillan Publishers Limited All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59736
ISSN
2015 Impact Factor: 5.337
2015 SCImago Journal Rankings: 2.752
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Pioneer Fund, New York
National Institute of Alcohol Abuse and AlcoholismAA-12502
AA-00145
AA-09203
Academy of Finland100499
205585
US National Institute of HealthDA13240
DA05147
AA09367
Australian twin data collectionA79600334
A79906588
A79801419
DP0212016
DP0343921
National Natural Science Foundation of China30772393
New Century Excellent Talents in University, National Ministry of EducationNCET06-0720
Guangzhou Science and Technology Development Fund2006Z3-E0061
Brain Science and Education Program (II)
RISTEX, JST
NIMHMH20030
NIHEY-12562
NWO/SPI 56-464-14192
NWO 480-04-004
NWO/VENI 451-04-034
Funding Information:

The South Korean Twin Registry has been supported by the Pioneer Fund, New York. The Finnish Twin Study is a part of the Academy of Finland Centre of Excellence in Complex Disease Genetics. The Finnish Twin Studies have been supported by the National Institute of Alcohol Abuse and Alcoholism (Grants AA-12502, AA-00145 and AA-09203 to RJR) and the Academy of Finland (Grants 100499, and 205585 to JK). The Minnesota Twin Family Study has been supported by the US National Institute of Health Grants, DA13240, DA05147 and AA09367. The Netherlands Twin Registry has been supported by NWO/SPI 56-464-14192, NWO 480-04-004, NWO/VENI 451-04-034 and NWO/Bilateral Agreement 463-06-001. Australian twin data collection was funded by ARC Grants (A79600334, A79906588, A79801419, DP0212016, DP0343921). The Guangzhou Twin Eye Studies have been supported by National Natural Science Foundation of China 30772393, Program for New Century Excellent Talents in University, National Ministry of Education NCET06-0720, and Guangzhou Science and Technology Development Fund 2006Z3-E0061. Funding resource for the Japanese Twin Studies are Brain Science and Education Program (II), RISTEX, JST. In addition, we acknowledge NIMH Grant MH20030 awarded to Karen Mitchell (PI: Michael Neale) and NIH Grant EY-12562 awarded to Stacey Cherny.

References

 

DC FieldValueLanguage
dc.contributor.authorHur, YMen_HK
dc.contributor.authorKaprio, Jen_HK
dc.contributor.authorIacono, WGen_HK
dc.contributor.authorBoomsma, DIen_HK
dc.contributor.authorMcGue, Men_HK
dc.contributor.authorSilventoinen, Ken_HK
dc.contributor.authorMartin, NGen_HK
dc.contributor.authorLuciano, Men_HK
dc.contributor.authorVisscher, PMen_HK
dc.contributor.authorRose, RJen_HK
dc.contributor.authorHe, Men_HK
dc.contributor.authorAndo, Jen_HK
dc.contributor.authorOoki, Sen_HK
dc.contributor.authorNonaka, Ken_HK
dc.contributor.authorLin, CCHen_HK
dc.contributor.authorLajunen, HRen_HK
dc.contributor.authorCornes, BKen_HK
dc.contributor.authorBartels, Men_HK
dc.contributor.authorVan Beijsterveldt, CEMen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorMitchell, Ken_HK
dc.date.accessioned2010-05-31T03:56:22Z-
dc.date.available2010-05-31T03:56:22Z-
dc.date.issued2008en_HK
dc.identifier.citationInternational Journal Of Obesity, 2008, v. 32 n. 10, p. 1455-1467en_HK
dc.identifier.issn0307-0565en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59736-
dc.description.abstractObjective: Twin studies are useful for investigating the causes of trait variation between as well as within a population. The goals of the present study were two-fold: First, we aimed to compare the total phenotypic, genetic and environmental variances of height, weight and BMI between Caucasians and East Asians using twins. Secondly, we intended to estimate the extent to which genetic and environmental factors contribute to differences in variability of height, weight and BMI between Caucasians and East Asians. Design: Height and weight data from 3735 Caucasian and 1584 East Asian twin pairs (age: 13-15 years) from Australia, China, Finland, Japan, the Netherlands, South Korea, Taiwan and the United States were used for analyses. Maximum likelihood twin correlations and variance components model-fitting analyses were conducted to fulfill the goals of the present study. Results: The absolute genetic variances for height, weight and BMI were consistently greater in Caucasians than in East Asians with corresponding differences in total variances for all three body measures. In all 80 to 100% of the differences in total variances of height, weight and BMI between the two population groups were associated with genetic differences. Conclusion: Height, weight and BMI were more variable in Caucasian than in East Asian adolescents. Genetic variances for these three body measures were also larger in Caucasians than in East Asians. Variance components model-fitting analyses indicated that genetic factors contributed to the difference in variability of height, weight and BMI between the two population groups. Association studies for these body measures should take account of our findings of differences in genetic variances between the two population groups. © 2008 Macmillan Publishers Limited All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ijo/en_HK
dc.relation.ispartofInternational Journal of Obesityen_HK
dc.subjectBMIen_HK
dc.subjectGenesen_HK
dc.subjectHeighten_HK
dc.subjectPopulation groupen_HK
dc.subjectTwinsen_HK
dc.subjectWeighten_HK
dc.titleGenetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twinsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0307-0565&volume=32&spage=1455&epage=1467&date=2008&atitle=Genetic+influences+on+the+difference+in+variability+of+height,+weight+and+body+mass+index+between+Caucasian+and+East+Asian+adolescent+twinsen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ijo.2008.144en_HK
dc.identifier.pmid18779828en_HK
dc.identifier.pmcidPMC2577073-
dc.identifier.scopuseid_2-s2.0-53849129190en_HK
dc.identifier.hkuros153464en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-53849129190&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1455en_HK
dc.identifier.epage1467en_HK
dc.identifier.eissn1476-5497-
dc.identifier.isiWOS:000259929200001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHur, YM=7006335989en_HK
dc.identifier.scopusauthoridKaprio, J=35379599600en_HK
dc.identifier.scopusauthoridIacono, WG=26643122100en_HK
dc.identifier.scopusauthoridBoomsma, DI=35378012400en_HK
dc.identifier.scopusauthoridMcGue, M=7005473131en_HK
dc.identifier.scopusauthoridSilventoinen, K=6603957862en_HK
dc.identifier.scopusauthoridMartin, NG=35376988300en_HK
dc.identifier.scopusauthoridLuciano, M=7006850167en_HK
dc.identifier.scopusauthoridVisscher, PM=7102668046en_HK
dc.identifier.scopusauthoridRose, RJ=7402136810en_HK
dc.identifier.scopusauthoridHe, M=15765257500en_HK
dc.identifier.scopusauthoridAndo, J=7102285353en_HK
dc.identifier.scopusauthoridOoki, S=23668673900en_HK
dc.identifier.scopusauthoridNonaka, K=7202426530en_HK
dc.identifier.scopusauthoridLin, CCH=36066132800en_HK
dc.identifier.scopusauthoridLajunen, HR=35316079700en_HK
dc.identifier.scopusauthoridCornes, BK=8083360800en_HK
dc.identifier.scopusauthoridBartels, M=7102291011en_HK
dc.identifier.scopusauthoridVan Beijsterveldt, CEM=6601910290en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridMitchell, K=8367933400en_HK
dc.identifier.citeulike3212151-

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