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Article: An association study of ADSS gene polymorphisms with schizophrenia

TitleAn association study of ADSS gene polymorphisms with schizophrenia
Authors
Issue Date2008
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.behavioralandbrainfunctions.com/home
Citation
Behavioral And Brain Functions, 2008, v. 4 How to Cite?
AbstractBackground: Adenylosuccinate synthase (ADSS) catalyzes the first committed step of AMP synthesis. It was suggested that the blood-derived RNA of ADSS was down-regulated in schizophrenia (SZ) and one of the eight putative biomarker genes to discriminate SZ from normal controls. However, it remains unclear whether the reduction of ADSS RNA is due to the polymorphisms of the gene or not. Methods: We attempted to examine the association of ADSS gene with schizophrenia in a Chinese population of 480 schizophrenics and 502 normal controls. Genotyping was performed by the Sequenom platform. Results: The 6 marker SNPs (rs3102460, rs3127459, rs3127460, rs3127465, rs3006001, and rs3003211) were genotyped. The frequencies of alleles, genotypes, and haplotypes were tested between cases and controls. There was no significant difference of genotypic, allelic, or haplotypic distributions of the 6 SNPs between the two groups. Conclusion: Our data did not support ADSS gene as a susceptibility gene for SZ in Chinese Han population. Large sample size study is needed to validate or replicate our association study, especially from other ethnic populations. © 2008 Zhang et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/59735
ISSN
2015 Impact Factor: 1.72
2015 SCImago Journal Rankings: 0.989
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30570430
Tsinghua- Yu- Yuan Medical Sciences Fund
Wellcome Trust
Funding Information:

The project was funded by National Natural Science Foundation of China (30570430) (LPZ, ZFQ), Tsinghua- Yu- Yuan Medical Sciences Fund (LPZ, ZFQ), and Collaboration Grant from the Wellcome Trust for funding ( SPC, SHC, SYQ).

References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Fen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorFan, Hen_HK
dc.contributor.authorXu, Yen_HK
dc.contributor.authorHuang, Xen_HK
dc.contributor.authorSo, Hen_HK
dc.contributor.authorSong, Yen_HK
dc.contributor.authorLiu, Pen_HK
dc.date.accessioned2010-05-31T03:56:20Z-
dc.date.available2010-05-31T03:56:20Z-
dc.date.issued2008en_HK
dc.identifier.citationBehavioral And Brain Functions, 2008, v. 4en_HK
dc.identifier.issn1744-9081en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59735-
dc.description.abstractBackground: Adenylosuccinate synthase (ADSS) catalyzes the first committed step of AMP synthesis. It was suggested that the blood-derived RNA of ADSS was down-regulated in schizophrenia (SZ) and one of the eight putative biomarker genes to discriminate SZ from normal controls. However, it remains unclear whether the reduction of ADSS RNA is due to the polymorphisms of the gene or not. Methods: We attempted to examine the association of ADSS gene with schizophrenia in a Chinese population of 480 schizophrenics and 502 normal controls. Genotyping was performed by the Sequenom platform. Results: The 6 marker SNPs (rs3102460, rs3127459, rs3127460, rs3127465, rs3006001, and rs3003211) were genotyped. The frequencies of alleles, genotypes, and haplotypes were tested between cases and controls. There was no significant difference of genotypic, allelic, or haplotypic distributions of the 6 SNPs between the two groups. Conclusion: Our data did not support ADSS gene as a susceptibility gene for SZ in Chinese Han population. Large sample size study is needed to validate or replicate our association study, especially from other ethnic populations. © 2008 Zhang et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.behavioralandbrainfunctions.com/homeen_HK
dc.relation.ispartofBehavioral and Brain Functionsen_HK
dc.rightsBehavioral and Brain Functions. Copyright © BioMed Central Ltd.en_HK
dc.titleAn association study of ADSS gene polymorphisms with schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1744-9081&volume=4-39&spage=1186&epage=&date=2008&atitle=An+association+study+of+ADSS+gene+polymorphisms+with+schizophreniaen_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1186/1744-9081-4-39en_HK
dc.identifier.scopuseid_2-s2.0-54749095185en_HK
dc.identifier.hkuros152292en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-54749095185&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume4en_HK
dc.identifier.isiWOS:000259706100001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZhang, F=8949970600en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridFan, H=36339159100en_HK
dc.identifier.scopusauthoridXu, Y=7406449753en_HK
dc.identifier.scopusauthoridHuang, X=25625177700en_HK
dc.identifier.scopusauthoridSo, H=37031934700en_HK
dc.identifier.scopusauthoridSong, Y=15830670600en_HK
dc.identifier.scopusauthoridLiu, P=25652665500en_HK
dc.identifier.citeulike3152586-

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