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Article: Linkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settings

TitleLinkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settings
Authors
KeywordsADHD
linkage
QTL
Issue Date2008
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiat
Citation
Biological Psychiatry, 2008, v. 64 n. 7, p. 571-576 How to Cite?
AbstractBackground: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). Methods: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. Results: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait. Conclusions: These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia. © 2008 Society of Biological Psychiatry.
Persistent Identifierhttp://hdl.handle.net/10722/59733
ISSN
2014 Impact Factor: 10.255
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, Ken_HK
dc.contributor.authorAsherson, Pen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorFranke, Ben_HK
dc.contributor.authorAnney, RJLen_HK
dc.contributor.authorBuitelaar, Jen_HK
dc.contributor.authorEbstein, Ren_HK
dc.contributor.authorGill, Men_HK
dc.contributor.authorBrookes, Ken_HK
dc.contributor.authorBuschgens, Cen_HK
dc.contributor.authorCampbell, Den_HK
dc.contributor.authorChen, Wen_HK
dc.contributor.authorChristiansen, Hen_HK
dc.contributor.authorFliers, Een_HK
dc.contributor.authorGabriëls, Ien_HK
dc.contributor.authorJohansson, Len_HK
dc.contributor.authorMarco, Ren_HK
dc.contributor.authorMulas, Fen_HK
dc.contributor.authorMüller, Uen_HK
dc.contributor.authorMulligan, Aen_HK
dc.contributor.authorNeale, BMen_HK
dc.contributor.authorRijsdijk, Fen_HK
dc.contributor.authorRommelse, Nen_HK
dc.contributor.authorUebel, Hen_HK
dc.contributor.authorPsychogiou, Len_HK
dc.contributor.authorXu, Xen_HK
dc.contributor.authorBanaschewski, Ten_HK
dc.contributor.authorSonugaBarke, Een_HK
dc.contributor.authorEisenberg, Jen_HK
dc.contributor.authorManor, Ien_HK
dc.contributor.authorMiranda, Aen_HK
dc.contributor.authorOades, RDen_HK
dc.contributor.authorRoeyers, Hen_HK
dc.contributor.authorRothenberger, Aen_HK
dc.contributor.authorSergeant, Jen_HK
dc.contributor.authorSteinhausen, HCen_HK
dc.contributor.authorTaylor, Een_HK
dc.contributor.authorThompson, Men_HK
dc.contributor.authorFaraone, SVen_HK
dc.date.accessioned2010-05-31T03:56:18Z-
dc.date.available2010-05-31T03:56:18Z-
dc.date.issued2008en_HK
dc.identifier.citationBiological Psychiatry, 2008, v. 64 n. 7, p. 571-576en_HK
dc.identifier.issn0006-3223en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59733-
dc.description.abstractBackground: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). Methods: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. Results: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait. Conclusions: These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia. © 2008 Society of Biological Psychiatry.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiaten_HK
dc.relation.ispartofBiological Psychiatryen_HK
dc.rightsBiological Psychiatry. Copyright © Elsevier Inc.en_HK
dc.subjectADHDen_HK
dc.subjectlinkageen_HK
dc.subjectQTLen_HK
dc.titleLinkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settingsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-3223&volume=64&spage=571&epage=576&date=2008&atitle=Linkage+to+Chromosome+1p36+for+Attention-Deficit/Hyperactivity+Disorder+Traits+in+School+and+Home+Settingsen_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.biopsych.2008.02.024en_HK
dc.identifier.pmid18439570en_HK
dc.identifier.scopuseid_2-s2.0-46349103630en_HK
dc.identifier.hkuros158103en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-46349103630&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume64en_HK
dc.identifier.issue7en_HK
dc.identifier.spage571en_HK
dc.identifier.epage576en_HK
dc.identifier.isiWOS:000259588600004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhou, K=22837296400en_HK
dc.identifier.scopusauthoridAsherson, P=35402700900en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridFranke, B=7005326255en_HK
dc.identifier.scopusauthoridAnney, RJL=6507478936en_HK
dc.identifier.scopusauthoridBuitelaar, J=26640178500en_HK
dc.identifier.scopusauthoridEbstein, R=7007152650en_HK
dc.identifier.scopusauthoridGill, M=35228962600en_HK
dc.identifier.scopusauthoridBrookes, K=8921920600en_HK
dc.identifier.scopusauthoridBuschgens, C=14718883900en_HK
dc.identifier.scopusauthoridCampbell, D=16041366500en_HK
dc.identifier.scopusauthoridChen, W=35975528400en_HK
dc.identifier.scopusauthoridChristiansen, H=8954661000en_HK
dc.identifier.scopusauthoridFliers, E=8654609300en_HK
dc.identifier.scopusauthoridGabriëls, I=24072954900en_HK
dc.identifier.scopusauthoridJohansson, L=24074700500en_HK
dc.identifier.scopusauthoridMarco, R=23392905500en_HK
dc.identifier.scopusauthoridMulas, F=7004054009en_HK
dc.identifier.scopusauthoridMüller, U=12242861600en_HK
dc.identifier.scopusauthoridMulligan, A=23570979700en_HK
dc.identifier.scopusauthoridNeale, BM=7003484514en_HK
dc.identifier.scopusauthoridRijsdijk, F=6701830835en_HK
dc.identifier.scopusauthoridRommelse, N=14720195600en_HK
dc.identifier.scopusauthoridUebel, H=22982364200en_HK
dc.identifier.scopusauthoridPsychogiou, L=22635632800en_HK
dc.identifier.scopusauthoridXu, X=7405294989en_HK
dc.identifier.scopusauthoridBanaschewski, T=6603935963en_HK
dc.identifier.scopusauthoridSonugaBarke, E=7005682785en_HK
dc.identifier.scopusauthoridEisenberg, J=7102686191en_HK
dc.identifier.scopusauthoridManor, I=6701576599en_HK
dc.identifier.scopusauthoridMiranda, A=35403188200en_HK
dc.identifier.scopusauthoridOades, RD=7006782221en_HK
dc.identifier.scopusauthoridRoeyers, H=6701645061en_HK
dc.identifier.scopusauthoridRothenberger, A=7005835367en_HK
dc.identifier.scopusauthoridSergeant, J=7004036780en_HK
dc.identifier.scopusauthoridSteinhausen, HC=7102832892en_HK
dc.identifier.scopusauthoridTaylor, E=7403206584en_HK
dc.identifier.scopusauthoridThompson, M=14526195300en_HK
dc.identifier.scopusauthoridFaraone, SV=36047714700en_HK

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