Article: Linkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settings

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TitleLinkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settings
AuthorsZhou, K3
Asherson, P3
Sham, P3 4
Franke, B14 16
Anney, RJL1
Buitelaar, J16
Ebstein, R8
Gill, M1
Brookes, K3
Buschgens, C16
Campbell, D3
Chen, W3
Christiansen, H13
Fliers, E16
Gabriëls, I6
Johansson, L3
Marco, R9
Mulas, F12
Müller, U17
Mulligan, A1 9
Neale, BM3
Rijsdijk, F3
Rommelse, N15
Uebel, H7
Psychogiou, L5
Xu, X3
Banaschewski, T7 11
SonugaBarke, E3 5 6 10
Eisenberg, J8
Manor, I2
Miranda, A1
Oades, RD13
Roeyers, H6
Rothenberger, A7
Sergeant, J15
Steinhausen, HC17
Taylor, E3
Thompson, M5
Faraone, SV18
KeywordsADHD
linkage
QTL
Issue Date2008
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiat
CitationBiological Psychiatry, 2008, v. 64 n. 7, p. 571-576 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.biopsych.2008.02.024
AbstractBackground: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). Methods: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. Results: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait. Conclusions: These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia. © 2008 Society of Biological Psychiatry.
ISSN0006-3223
2011 Impact Factor: 8.283
2011 SCImago Journal Rankings: 0.604
DOIhttp://dx.doi.org/10.1016/j.biopsych.2008.02.024
ISI Accession Number IDWOS:000259588600004
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorZhou, K
dc.contributor.authorAsherson, P
dc.contributor.authorSham, P
dc.contributor.authorFranke, B
dc.contributor.authorAnney, RJL
dc.contributor.authorBuitelaar, J
dc.contributor.authorEbstein, R
dc.contributor.authorGill, M
dc.contributor.authorBrookes, K
dc.contributor.authorBuschgens, C
dc.contributor.authorCampbell, D
dc.contributor.authorChen, W
dc.contributor.authorChristiansen, H
dc.contributor.authorFliers, E
dc.contributor.authorGabriëls, I
dc.contributor.authorJohansson, L
dc.contributor.authorMarco, R
dc.contributor.authorMulas, F
dc.contributor.authorMüller, U
dc.contributor.authorMulligan, A
dc.contributor.authorNeale, BM
dc.contributor.authorRijsdijk, F
dc.contributor.authorRommelse, N
dc.contributor.authorUebel, H
dc.contributor.authorPsychogiou, L
dc.contributor.authorXu, X
dc.contributor.authorBanaschewski, T
dc.contributor.authorSonugaBarke, E
dc.contributor.authorEisenberg, J
dc.contributor.authorManor, I
dc.contributor.authorMiranda, A
dc.contributor.authorOades, RD
dc.contributor.authorRoeyers, H
dc.contributor.authorRothenberger, A
dc.contributor.authorSergeant, J
dc.contributor.authorSteinhausen, HC
dc.contributor.authorTaylor, E
dc.contributor.authorThompson, M
dc.contributor.authorFaraone, SV
dc.date.accessioned2010-05-31T03:56:18Z
dc.date.available2010-05-31T03:56:18Z
dc.date.issued2008
dc.description.abstractBackground: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). Methods: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. Results: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait. Conclusions: These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia. © 2008 Society of Biological Psychiatry.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationBiological Psychiatry, 2008, v. 64 n. 7, p. 571-576 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.biopsych.2008.02.024
dc.identifier.doihttp://dx.doi.org/10.1016/j.biopsych.2008.02.024
dc.identifier.epage576
dc.identifier.hkuros158103
dc.identifier.isiWOS:000259588600004
dc.identifier.issn0006-3223
2011 Impact Factor: 8.283
2011 SCImago Journal Rankings: 0.604
dc.identifier.issue7
dc.identifier.openurl
dc.identifier.pmid18439570
dc.identifier.scopuseid_2-s2.0-46349103630
dc.identifier.spage571
dc.identifier.urihttp://hdl.handle.net/10722/59733
dc.identifier.volume64
dc.languageeng
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiat
dc.publisher.placeUnited States
dc.relation.ispartofBiological Psychiatry
dc.relation.referencesReferences in Scopus
dc.rightsBiological Psychiatry. Copyright © Elsevier Inc.
dc.subjectADHD
dc.subjectlinkage
dc.subjectQTL
dc.titleLinkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settings
dc.typeArticle
Author Affiliations
  1. Trinity College Dublin
  2. Geha Mental Health Center
  3. King's College London
  4. The University of Hong Kong Li Ka Shing Faculty of Medicine
  5. University of Southampton
  6. Universiteit Gent
  7. Universität Göttingen
  8. Herzog Hospital Jerusalem
  9. Universitat de Valencia
  10. New York University
  11. Zentralinstitut für Seelische Gesundheit
  12. Hospital Universitario La Fe
  13. Universitäts Klinikum Essen und Medizinische Fakultät
  14. Radboud University Nijmegen
  15. Vrije Universiteit Amsterdam
  16. Radboud University Nijmegen Medical Centre
  17. Universität Zürich
  18. State University of New York Upstate Medical University