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Article: Linkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settings
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TitleLinkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settings
 
AuthorsZhou, K3
Asherson, P3
Sham, P1 3
Franke, B16 14
Anney, RJL4
Buitelaar, J16
Ebstein, R8
Gill, M4
Brookes, K3
Buschgens, C16
Campbell, D3
Chen, W3
Christiansen, H13
Fliers, E16
Gabriëls, I5
Johansson, L3
Marco, R10
Mulas, F12
Müller, U17
Mulligan, A4 10
Neale, BM3
Rijsdijk, F3
Rommelse, N15
Uebel, H7
Psychogiou, L6
Xu, X3
Banaschewski, T7 11
SonugaBarke, E5 6 9 3
Eisenberg, J8
Manor, I2
Miranda, A4
Oades, RD13
Roeyers, H5
Rothenberger, A7
Sergeant, J15
Steinhausen, HC17
Taylor, E3
Thompson, M6
Faraone, SV18
 
KeywordsADHD
linkage
QTL
 
Issue Date2008
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiat
 
CitationBiological Psychiatry, 2008, v. 64 n. 7, p. 571-576 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.biopsych.2008.02.024
 
AbstractBackground: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). Methods: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. Results: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait. Conclusions: These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia. © 2008 Society of Biological Psychiatry.
 
ISSN0006-3223
2013 Impact Factor: 9.472
 
DOIhttp://dx.doi.org/10.1016/j.biopsych.2008.02.024
 
ISI Accession Number IDWOS:000259588600004
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhou, K
 
dc.contributor.authorAsherson, P
 
dc.contributor.authorSham, P
 
dc.contributor.authorFranke, B
 
dc.contributor.authorAnney, RJL
 
dc.contributor.authorBuitelaar, J
 
dc.contributor.authorEbstein, R
 
dc.contributor.authorGill, M
 
dc.contributor.authorBrookes, K
 
dc.contributor.authorBuschgens, C
 
dc.contributor.authorCampbell, D
 
dc.contributor.authorChen, W
 
dc.contributor.authorChristiansen, H
 
dc.contributor.authorFliers, E
 
dc.contributor.authorGabriëls, I
 
dc.contributor.authorJohansson, L
 
dc.contributor.authorMarco, R
 
dc.contributor.authorMulas, F
 
dc.contributor.authorMüller, U
 
dc.contributor.authorMulligan, A
 
dc.contributor.authorNeale, BM
 
dc.contributor.authorRijsdijk, F
 
dc.contributor.authorRommelse, N
 
dc.contributor.authorUebel, H
 
dc.contributor.authorPsychogiou, L
 
dc.contributor.authorXu, X
 
dc.contributor.authorBanaschewski, T
 
dc.contributor.authorSonugaBarke, E
 
dc.contributor.authorEisenberg, J
 
dc.contributor.authorManor, I
 
dc.contributor.authorMiranda, A
 
dc.contributor.authorOades, RD
 
dc.contributor.authorRoeyers, H
 
dc.contributor.authorRothenberger, A
 
dc.contributor.authorSergeant, J
 
dc.contributor.authorSteinhausen, HC
 
dc.contributor.authorTaylor, E
 
dc.contributor.authorThompson, M
 
dc.contributor.authorFaraone, SV
 
dc.date.accessioned2010-05-31T03:56:18Z
 
dc.date.available2010-05-31T03:56:18Z
 
dc.date.issued2008
 
dc.description.abstractBackground: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). Methods: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. Results: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait. Conclusions: These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia. © 2008 Society of Biological Psychiatry.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationBiological Psychiatry, 2008, v. 64 n. 7, p. 571-576 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.biopsych.2008.02.024
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.biopsych.2008.02.024
 
dc.identifier.epage576
 
dc.identifier.hkuros158103
 
dc.identifier.isiWOS:000259588600004
 
dc.identifier.issn0006-3223
2013 Impact Factor: 9.472
 
dc.identifier.issue7
 
dc.identifier.openurl
 
dc.identifier.pmid18439570
 
dc.identifier.scopuseid_2-s2.0-46349103630
 
dc.identifier.spage571
 
dc.identifier.urihttp://hdl.handle.net/10722/59733
 
dc.identifier.volume64
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiat
 
dc.publisher.placeUnited States
 
dc.relation.ispartofBiological Psychiatry
 
dc.relation.referencesReferences in Scopus
 
dc.rightsBiological Psychiatry. Copyright © Elsevier Inc.
 
dc.subjectADHD
 
dc.subjectlinkage
 
dc.subjectQTL
 
dc.titleLinkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settings
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Geha Mental Health Center
  3. King's College London
  4. Trinity College Dublin
  5. Universiteit Gent
  6. University of Southampton
  7. Universität Göttingen
  8. Herzog Hospital Jerusalem
  9. New York University
  10. Universitat de Valencia
  11. Zentralinstitut für Seelische Gesundheit
  12. Hospital Universitario La Fe
  13. Universitäts Klinikum Essen und Medizinische Fakultät
  14. Radboud University Nijmegen
  15. Vrije Universiteit Amsterdam
  16. Radboud University Nijmegen Medical Centre
  17. Universität Zürich
  18. State University of New York Upstate Medical University