File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Association analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population

TitleAssociation analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population
Authors
Issue Date2008
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcmedgenet/
Citation
Bmc Medical Genetics, 2008, v. 9 How to Cite?
AbstractBackground: The blood-derived RNA levels of the adenylosuccinate synthase (ADSS) and ataxia telangiectasia mutated (ATM) genes were found to be down- and up-regulated, respectively, in schizophrenics compared with controls, and ADSS and ATM were among eight biomarker genes to discriminate schizophrenics from normal controls. ADSS catalyzes the first committed step of AMP synthesis, while ATM kinase serves as a key signal transducer in the DNA double-strand breaks response pathway. It remains unclear whether these changes result from mutations or polymorphisms in the two genes. Methods: Six SNPs in the ADSS gene and three SNPs in the ATM gene in a Chinese population of 488 schizophrenics and 516 controls were genotyped to examine their association with schizophrenia (SZ). Genotyping was performed using the Sequenom platform. Results: There was no significant difference in the genotype, allele, or haplotype distributions of the nine SNPs between cases and controls. Using the Multifactor Dimensionality Reduction (MDR) method, we found that the interactions among rs3102460 in the ADSS gene and rs227061 and rs664143 in the ATM gene revealed a significant association with SZ. This model held a maximum testing accuracy of 60.4% and a maximum cross-validation consistency of 10 out of 10. Conclusion: These findings suggest that the combined effects of the polymorphisms in the ADSS and ATM genes may confer susceptibility to the development of SZ in a Chinese population. © 2008 Zhang et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/59732
ISSN
2015 Impact Factor: 2.094
2015 SCImago Journal Rankings: 1.062
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Fen_HK
dc.contributor.authorXu, Yen_HK
dc.contributor.authorLiu, Pen_HK
dc.contributor.authorFan, Hen_HK
dc.contributor.authorHuang, Xen_HK
dc.contributor.authorSun, Gen_HK
dc.contributor.authorSong, Yen_HK
dc.contributor.authorSham, PCen_HK
dc.date.accessioned2010-05-31T03:56:16Z-
dc.date.available2010-05-31T03:56:16Z-
dc.date.issued2008en_HK
dc.identifier.citationBmc Medical Genetics, 2008, v. 9en_HK
dc.identifier.issn1471-2350en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59732-
dc.description.abstractBackground: The blood-derived RNA levels of the adenylosuccinate synthase (ADSS) and ataxia telangiectasia mutated (ATM) genes were found to be down- and up-regulated, respectively, in schizophrenics compared with controls, and ADSS and ATM were among eight biomarker genes to discriminate schizophrenics from normal controls. ADSS catalyzes the first committed step of AMP synthesis, while ATM kinase serves as a key signal transducer in the DNA double-strand breaks response pathway. It remains unclear whether these changes result from mutations or polymorphisms in the two genes. Methods: Six SNPs in the ADSS gene and three SNPs in the ATM gene in a Chinese population of 488 schizophrenics and 516 controls were genotyped to examine their association with schizophrenia (SZ). Genotyping was performed using the Sequenom platform. Results: There was no significant difference in the genotype, allele, or haplotype distributions of the nine SNPs between cases and controls. Using the Multifactor Dimensionality Reduction (MDR) method, we found that the interactions among rs3102460 in the ADSS gene and rs227061 and rs664143 in the ATM gene revealed a significant association with SZ. This model held a maximum testing accuracy of 60.4% and a maximum cross-validation consistency of 10 out of 10. Conclusion: These findings suggest that the combined effects of the polymorphisms in the ADSS and ATM genes may confer susceptibility to the development of SZ in a Chinese population. © 2008 Zhang et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcmedgenet/en_HK
dc.relation.ispartofBMC Medical Geneticsen_HK
dc.rightsB M C Medical Genetics. Copyright © BioMed Central Ltd.en_HK
dc.titleAssociation analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese populationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1471-2350&volume=9&spage=119&epage=&date=2008&atitle=Association+analyses+of+the+interaction+between+the+ADSS+and+ATM+genes+with+schizophrenia+in+a+Chinese+populationen_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1186/1471-2350-9-119en_HK
dc.identifier.pmid19115993-
dc.identifier.scopuseid_2-s2.0-62349109990en_HK
dc.identifier.hkuros158099en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-62349109990&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.isiWOS:000264152500001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZhang, F=8949970600en_HK
dc.identifier.scopusauthoridXu, Y=7406449753en_HK
dc.identifier.scopusauthoridLiu, P=25652665500en_HK
dc.identifier.scopusauthoridFan, H=36339159100en_HK
dc.identifier.scopusauthoridHuang, X=25625177700en_HK
dc.identifier.scopusauthoridSun, G=26325137300en_HK
dc.identifier.scopusauthoridSong, Y=15830670600en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.citeulike3837719-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats