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Article: Genetics of schizophrenia spectrum disorders: Looking back and peering ahead

TitleGenetics of schizophrenia spectrum disorders: Looking back and peering ahead
Authors
KeywordsCopy number variation
Genome-wide association
Linkage
Issue Date2009
PublisherAcademy of Medicine Singapore. The Journal's web site is located at http://www.annals.edu.sg
Citation
Annals Of The Academy Of Medicine Singapore, 2009, v. 38 n. 5, p. 436-439 How to Cite?
AbstractThe genetics of schizophrenia spectrum disorders have come a long way since the early demonstration of a substantial genetic component by family, twin and adoption studies. After over a decade of intensive molecular genetic studies, initially by linkage scans and candidate gene association studies, and more recently genome-wide association studies, a picture is now emerging that susceptibility to schizophrenia spectrum disorders is determined by many genetic variants of different types, ranging from single nucleotide polymorphisms to copy number variants, including rare and de novo variants, of pleiotropic effects on multiple diagnoses and traits. Further large-scale genome-wide association studies, and the forthcoming availability of affordable whole-genome sequencing technology, will further characterise the genetic variants involved, which in turn will be translated to improved clinical practice.
Persistent Identifierhttp://hdl.handle.net/10722/59727
ISSN
2015 Impact Factor: 1.041
2015 SCImago Journal Rankings: 0.425
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSo, HCen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorSham, PCen_HK
dc.date.accessioned2010-05-31T03:56:11Z-
dc.date.available2010-05-31T03:56:11Z-
dc.date.issued2009en_HK
dc.identifier.citationAnnals Of The Academy Of Medicine Singapore, 2009, v. 38 n. 5, p. 436-439en_HK
dc.identifier.issn0304-4602en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59727-
dc.description.abstractThe genetics of schizophrenia spectrum disorders have come a long way since the early demonstration of a substantial genetic component by family, twin and adoption studies. After over a decade of intensive molecular genetic studies, initially by linkage scans and candidate gene association studies, and more recently genome-wide association studies, a picture is now emerging that susceptibility to schizophrenia spectrum disorders is determined by many genetic variants of different types, ranging from single nucleotide polymorphisms to copy number variants, including rare and de novo variants, of pleiotropic effects on multiple diagnoses and traits. Further large-scale genome-wide association studies, and the forthcoming availability of affordable whole-genome sequencing technology, will further characterise the genetic variants involved, which in turn will be translated to improved clinical practice.en_HK
dc.languageengen_HK
dc.publisherAcademy of Medicine Singapore. The Journal's web site is located at http://www.annals.edu.sgen_HK
dc.relation.ispartofAnnals of the Academy of Medicine Singaporeen_HK
dc.subjectCopy number variationen_HK
dc.subjectGenome-wide associationen_HK
dc.subjectLinkageen_HK
dc.titleGenetics of schizophrenia spectrum disorders: Looking back and peering aheaden_HK
dc.typeArticleen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid19521646-
dc.identifier.scopuseid_2-s2.0-67049110431en_HK
dc.identifier.hkuros160234en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67049110431&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue5en_HK
dc.identifier.spage436en_HK
dc.identifier.epage439en_HK
dc.identifier.isiWOS:000267199100012-
dc.publisher.placeSingaporeen_HK
dc.identifier.scopusauthoridSo, HC=37031934700en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK

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