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Article: The functional MMP-9 microsatellite marker is not associated with episodic memory in humans

TitleThe functional MMP-9 microsatellite marker is not associated with episodic memory in humans
Authors
Issue Date2008
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychgenetics.com
Citation
Psychiatric Genetics, 2008, v. 18 n. 5, p. 252 How to Cite?
AbstractOne candidate gene for involvement in memory function is matrix metalloproteinase 9 (MMP-9). It is synthesized in neurons of the human hippocampus (Backstrom et al., 1996), and plays an important role in synaptic plasticity and hippocampal-dependent learning (Meighan et al., 2006). MMP-9 has a functional repeat polymorphism (CA)n in its promoter sequence (Shimajiri et al., 1999) and mice that lack the gene exhibit impairments in long-term potentiation and hippocampal-dependent associative learning. As this polymorphism is functional, and MMP-9 is involved in hippocampal memory and learning, we hypothesized that this polymorphism modulates human cognitive function. To test this, we genotyped the MMP-9 microsatellite in 449 normal Han Chinese participants who had taken a set of cognitive tests including episodic memory. No significant association between the polymorphic alleles or genotype and memory was detected. This is the first study to test the functional MMP-9 microsatellite polymorphism for association with memory in humans. The results do not support an influence of this polymorphism on memory function, in the population studied. The absence of a significant effect could be explained by the lack of short (low activity) alleles in our Asian sample. Another explanation for the lack of association could be that complex characteristics, such as memory, and MMP-9 enzyme activity do not have a linear correlation, as MMPs have both detrimental and beneficial effects on the central nervous system. Upregulation of MMP-9 has been reported in various neurological conditions and brain injury, suggesting neurotoxicity; however, a beneficial effect of MMP-9 on the repair process, such as axonal regeneration and myelination, has also been demonstrated (Yong, 2005). Apparently, our findings reflect the difficulty in associating biochemical alterations with complex psychological phenomena. © 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/59725
ISSN
2015 Impact Factor: 1.736
2015 SCImago Journal Rankings: 0.968
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorVassos, Een_HK
dc.contributor.authorMa, Xen_HK
dc.contributor.authorFiotti, Nen_HK
dc.contributor.authorWang, Qen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorYan, Cen_HK
dc.contributor.authorMeng, Hen_HK
dc.contributor.authorDeng, Wen_HK
dc.contributor.authorCollier, DAen_HK
dc.contributor.authorLi, Ten_HK
dc.date.accessioned2010-05-31T03:56:09Z-
dc.date.available2010-05-31T03:56:09Z-
dc.date.issued2008en_HK
dc.identifier.citationPsychiatric Genetics, 2008, v. 18 n. 5, p. 252en_HK
dc.identifier.issn0955-8829en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59725-
dc.description.abstractOne candidate gene for involvement in memory function is matrix metalloproteinase 9 (MMP-9). It is synthesized in neurons of the human hippocampus (Backstrom et al., 1996), and plays an important role in synaptic plasticity and hippocampal-dependent learning (Meighan et al., 2006). MMP-9 has a functional repeat polymorphism (CA)n in its promoter sequence (Shimajiri et al., 1999) and mice that lack the gene exhibit impairments in long-term potentiation and hippocampal-dependent associative learning. As this polymorphism is functional, and MMP-9 is involved in hippocampal memory and learning, we hypothesized that this polymorphism modulates human cognitive function. To test this, we genotyped the MMP-9 microsatellite in 449 normal Han Chinese participants who had taken a set of cognitive tests including episodic memory. No significant association between the polymorphic alleles or genotype and memory was detected. This is the first study to test the functional MMP-9 microsatellite polymorphism for association with memory in humans. The results do not support an influence of this polymorphism on memory function, in the population studied. The absence of a significant effect could be explained by the lack of short (low activity) alleles in our Asian sample. Another explanation for the lack of association could be that complex characteristics, such as memory, and MMP-9 enzyme activity do not have a linear correlation, as MMPs have both detrimental and beneficial effects on the central nervous system. Upregulation of MMP-9 has been reported in various neurological conditions and brain injury, suggesting neurotoxicity; however, a beneficial effect of MMP-9 on the repair process, such as axonal regeneration and myelination, has also been demonstrated (Yong, 2005). Apparently, our findings reflect the difficulty in associating biochemical alterations with complex psychological phenomena. © 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychgenetics.comen_HK
dc.relation.ispartofPsychiatric Geneticsen_HK
dc.rightsPsychiatric Genetics. Copyright © Lippincott Williams & Wilkins.en_HK
dc.titleThe functional MMP-9 microsatellite marker is not associated with episodic memory in humansen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0955-8829&volume=18&spage=252&epage=&date=2008&atitle=The+functional+MMP-9+microsatellite+marker+is+not+associated+with+episodic+memory+in+humansen_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/YPG.0b013e3283053009en_HK
dc.identifier.pmid18797400-
dc.identifier.scopuseid_2-s2.0-55049108691en_HK
dc.identifier.hkuros158071en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-55049108691&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue5en_HK
dc.identifier.spage252en_HK
dc.identifier.epage252en_HK
dc.identifier.isiWOS:000261473700006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridVassos, E=35369293900en_HK
dc.identifier.scopusauthoridMa, X=35354066000en_HK
dc.identifier.scopusauthoridFiotti, N=6603548449en_HK
dc.identifier.scopusauthoridWang, Q=7406916913en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridLiu, X=7409294386en_HK
dc.identifier.scopusauthoridWang, Y=7601517986en_HK
dc.identifier.scopusauthoridYan, C=24464486100en_HK
dc.identifier.scopusauthoridMeng, H=9133658800en_HK
dc.identifier.scopusauthoridDeng, W=7202222559en_HK
dc.identifier.scopusauthoridCollier, DA=26642980600en_HK
dc.identifier.scopusauthoridLi, T=36072008200en_HK

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