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Article: An association study of RGS4 polymorphisms with clinical phenotypes of schizophrenia in a Chinese population
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TitleAn association study of RGS4 polymorphisms with clinical phenotypes of schizophrenia in a Chinese population
 
AuthorsSo, HC3
Chen, RYL3
Chen, EYH3
Cheung, EFC4
Li, T2
Sham, PC1 3
 
KeywordsCandidate gene
Case-control
Haplotype
RGS4
Schizophrenia
 
Issue Date2008
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
 
CitationAmerican Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2008, v. 147 n. 1, p. 77-85 [How to Cite?]
DOI: http://dx.doi.org/10.1002/ajmg.b.30577
 
AbstractThe regulator of G-protein signaling 4 (RGS4) has been suggested as a candidate gene for schizophrenia. However, following an initial positive report, subsequent association studies between RGS4 and schizophrenia have yielded inconclusive results. Also, few studies have investigated the association of RGS4 polymorphisms with the phenotypic subgroups of schizophrenia. To further clarify the role of RGS4 in this disease, we performed a case-control study (504 cases and 531 controls of Han Chinese descent) to examine the association of RGS4 with schizophrenia and with clinical and neurocognitive profiles. The four markers (SNPs 1, 4, 7, and 18) implicated in the original association study were genotyped. We detected significant association of four-marker haplotypes with schizophrenia (UNPHASED: global P = 0.037; PHASE: global P = 0.048). The haplotype G-G-G-G, which was implicated in at least three previous studies, was the major risk haplotype (UNPHASED: P = 0.019; PHASE: P = 0.010). Regarding the clinical phenotypes, the Wechsler Adult Intelligence Test (WAIS) information subtest score was associated with SNP4 genotypes (P = 0.001). PANSS total and global psychopathology scores were also associated with SNP4, but may not reliably reflect the general severity of disease as the scores may be affected by confounders like medication response. Our study provides further support for a role of RGS4 in the pathogenesis of schizophrenia. We identified G-G-G-G as the risk haplotype in our Chinese sample. The association with information subtest score suggests an effect of RGS4 on premorbid functioning, which may be related to neurodevelopmental processes. Further independent studies are required to verify our findings. © 2007 Wiley-Liss, Inc.
 
ISSN1552-4841
2013 Impact Factor: 3.271
 
DOIhttp://dx.doi.org/10.1002/ajmg.b.30577
 
ISI Accession Number IDWOS:000251981400014
Funding AgencyGrant Number
Hong Kong Research Grants Council CERGHKU/7579/05M
Wellcome Trust
Funding Information:

The project was funded by Hong Kong Research Grants Council CERG HKU/7579/05M and by a Biomedical Collaboration Grant from the Wellcome Trust. We are also grateful to TCK Hui, CL Kwok, F Lieh-Mak, JH Zhao, D Collier, R Murray, HK Cheung, PC Lu, CH Yuen, and CK Lin for their help in subject recruitment.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorSo, HC
 
dc.contributor.authorChen, RYL
 
dc.contributor.authorChen, EYH
 
dc.contributor.authorCheung, EFC
 
dc.contributor.authorLi, T
 
dc.contributor.authorSham, PC
 
dc.date.accessioned2010-05-31T03:56:03Z
 
dc.date.available2010-05-31T03:56:03Z
 
dc.date.issued2008
 
dc.description.abstractThe regulator of G-protein signaling 4 (RGS4) has been suggested as a candidate gene for schizophrenia. However, following an initial positive report, subsequent association studies between RGS4 and schizophrenia have yielded inconclusive results. Also, few studies have investigated the association of RGS4 polymorphisms with the phenotypic subgroups of schizophrenia. To further clarify the role of RGS4 in this disease, we performed a case-control study (504 cases and 531 controls of Han Chinese descent) to examine the association of RGS4 with schizophrenia and with clinical and neurocognitive profiles. The four markers (SNPs 1, 4, 7, and 18) implicated in the original association study were genotyped. We detected significant association of four-marker haplotypes with schizophrenia (UNPHASED: global P = 0.037; PHASE: global P = 0.048). The haplotype G-G-G-G, which was implicated in at least three previous studies, was the major risk haplotype (UNPHASED: P = 0.019; PHASE: P = 0.010). Regarding the clinical phenotypes, the Wechsler Adult Intelligence Test (WAIS) information subtest score was associated with SNP4 genotypes (P = 0.001). PANSS total and global psychopathology scores were also associated with SNP4, but may not reliably reflect the general severity of disease as the scores may be affected by confounders like medication response. Our study provides further support for a role of RGS4 in the pathogenesis of schizophrenia. We identified G-G-G-G as the risk haplotype in our Chinese sample. The association with information subtest score suggests an effect of RGS4 on premorbid functioning, which may be related to neurodevelopmental processes. Further independent studies are required to verify our findings. © 2007 Wiley-Liss, Inc.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationAmerican Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2008, v. 147 n. 1, p. 77-85 [How to Cite?]
DOI: http://dx.doi.org/10.1002/ajmg.b.30577
 
dc.identifier.doihttp://dx.doi.org/10.1002/ajmg.b.30577
 
dc.identifier.epage85
 
dc.identifier.hkuros158054
 
dc.identifier.isiWOS:000251981400014
Funding AgencyGrant Number
Hong Kong Research Grants Council CERGHKU/7579/05M
Wellcome Trust
Funding Information:

The project was funded by Hong Kong Research Grants Council CERG HKU/7579/05M and by a Biomedical Collaboration Grant from the Wellcome Trust. We are also grateful to TCK Hui, CL Kwok, F Lieh-Mak, JH Zhao, D Collier, R Murray, HK Cheung, PC Lu, CH Yuen, and CK Lin for their help in subject recruitment.

 
dc.identifier.issn1552-4841
2013 Impact Factor: 3.271
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid17722013
 
dc.identifier.scopuseid_2-s2.0-37849016892
 
dc.identifier.spage77
 
dc.identifier.urihttp://hdl.handle.net/10722/59720
 
dc.identifier.volume147
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
 
dc.relation.referencesReferences in Scopus
 
dc.rightsAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics. Copyright © John Wiley & Sons, Inc.
 
dc.subjectCandidate gene
 
dc.subjectCase-control
 
dc.subjectHaplotype
 
dc.subjectRGS4
 
dc.subjectSchizophrenia
 
dc.titleAn association study of RGS4 polymorphisms with clinical phenotypes of schizophrenia in a Chinese population
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. King's College London
  3. The University of Hong Kong
  4. Castle Peak Hospital Hong Kong