File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: An association study of RGS4 polymorphisms with clinical phenotypes of schizophrenia in a Chinese population

TitleAn association study of RGS4 polymorphisms with clinical phenotypes of schizophrenia in a Chinese population
Authors
KeywordsCandidate gene
Case-control
Haplotype
RGS4
Schizophrenia
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/
Citation
American Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2008, v. 147 n. 1, p. 77-85 How to Cite?
AbstractThe regulator of G-protein signaling 4 (RGS4) has been suggested as a candidate gene for schizophrenia. However, following an initial positive report, subsequent association studies between RGS4 and schizophrenia have yielded inconclusive results. Also, few studies have investigated the association of RGS4 polymorphisms with the phenotypic subgroups of schizophrenia. To further clarify the role of RGS4 in this disease, we performed a case-control study (504 cases and 531 controls of Han Chinese descent) to examine the association of RGS4 with schizophrenia and with clinical and neurocognitive profiles. The four markers (SNPs 1, 4, 7, and 18) implicated in the original association study were genotyped. We detected significant association of four-marker haplotypes with schizophrenia (UNPHASED: global P = 0.037; PHASE: global P = 0.048). The haplotype G-G-G-G, which was implicated in at least three previous studies, was the major risk haplotype (UNPHASED: P = 0.019; PHASE: P = 0.010). Regarding the clinical phenotypes, the Wechsler Adult Intelligence Test (WAIS) information subtest score was associated with SNP4 genotypes (P = 0.001). PANSS total and global psychopathology scores were also associated with SNP4, but may not reliably reflect the general severity of disease as the scores may be affected by confounders like medication response. Our study provides further support for a role of RGS4 in the pathogenesis of schizophrenia. We identified G-G-G-G as the risk haplotype in our Chinese sample. The association with information subtest score suggests an effect of RGS4 on premorbid functioning, which may be related to neurodevelopmental processes. Further independent studies are required to verify our findings. © 2007 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/59720
ISSN
2015 Impact Factor: 3.391
2015 SCImago Journal Rankings: 1.771
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants Council CERGHKU/7579/05M
Wellcome Trust
Funding Information:

The project was funded by Hong Kong Research Grants Council CERG HKU/7579/05M and by a Biomedical Collaboration Grant from the Wellcome Trust. We are also grateful to TCK Hui, CL Kwok, F Lieh-Mak, JH Zhao, D Collier, R Murray, HK Cheung, PC Lu, CH Yuen, and CK Lin for their help in subject recruitment.

References

 

DC FieldValueLanguage
dc.contributor.authorSo, HCen_HK
dc.contributor.authorChen, RYLen_HK
dc.contributor.authorChen, EYHen_HK
dc.contributor.authorCheung, EFCen_HK
dc.contributor.authorLi, Ten_HK
dc.contributor.authorSham, PCen_HK
dc.date.accessioned2010-05-31T03:56:03Z-
dc.date.available2010-05-31T03:56:03Z-
dc.date.issued2008en_HK
dc.identifier.citationAmerican Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2008, v. 147 n. 1, p. 77-85en_HK
dc.identifier.issn1552-4841en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59720-
dc.description.abstractThe regulator of G-protein signaling 4 (RGS4) has been suggested as a candidate gene for schizophrenia. However, following an initial positive report, subsequent association studies between RGS4 and schizophrenia have yielded inconclusive results. Also, few studies have investigated the association of RGS4 polymorphisms with the phenotypic subgroups of schizophrenia. To further clarify the role of RGS4 in this disease, we performed a case-control study (504 cases and 531 controls of Han Chinese descent) to examine the association of RGS4 with schizophrenia and with clinical and neurocognitive profiles. The four markers (SNPs 1, 4, 7, and 18) implicated in the original association study were genotyped. We detected significant association of four-marker haplotypes with schizophrenia (UNPHASED: global P = 0.037; PHASE: global P = 0.048). The haplotype G-G-G-G, which was implicated in at least three previous studies, was the major risk haplotype (UNPHASED: P = 0.019; PHASE: P = 0.010). Regarding the clinical phenotypes, the Wechsler Adult Intelligence Test (WAIS) information subtest score was associated with SNP4 genotypes (P = 0.001). PANSS total and global psychopathology scores were also associated with SNP4, but may not reliably reflect the general severity of disease as the scores may be affected by confounders like medication response. Our study provides further support for a role of RGS4 in the pathogenesis of schizophrenia. We identified G-G-G-G as the risk haplotype in our Chinese sample. The association with information subtest score suggests an effect of RGS4 on premorbid functioning, which may be related to neurodevelopmental processes. Further independent studies are required to verify our findings. © 2007 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1/en_HK
dc.relation.ispartofAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Geneticsen_HK
dc.rightsAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectCandidate geneen_HK
dc.subjectCase-controlen_HK
dc.subjectHaplotypeen_HK
dc.subjectRGS4en_HK
dc.subjectSchizophreniaen_HK
dc.titleAn association study of RGS4 polymorphisms with clinical phenotypes of schizophrenia in a Chinese populationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1552-4841&volume=147B&spage=77&epage=85&date=2008&atitle=An+Association+Study+of+RGS4+Polymorphisms+With+Clinical+Phenotypes+of+Schizophrenia+in+a+Chinese+Populationen_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ajmg.b.30577en_HK
dc.identifier.pmid17722013-
dc.identifier.scopuseid_2-s2.0-37849016892en_HK
dc.identifier.hkuros158054en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37849016892&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume147en_HK
dc.identifier.issue1en_HK
dc.identifier.spage77en_HK
dc.identifier.epage85en_HK
dc.identifier.isiWOS:000251981400014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSo, HC=37031934700en_HK
dc.identifier.scopusauthoridChen, RYL=16635066600en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK
dc.identifier.scopusauthoridCheung, EFC=7006522469en_HK
dc.identifier.scopusauthoridLi, T=36072008200en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats