File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Neuregulin-1 and the P300 waveform-A preliminary association study using a psychosis endophenotype

TitleNeuregulin-1 and the P300 waveform-A preliminary association study using a psychosis endophenotype
Authors
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2008, v. 103 n. 1-3, p. 178-185 How to Cite?
AbstractObjective: Neuregulin-1 (NRG1) has been put forward as a susceptibility gene for schizophrenia. We investigated the association between Neuregulin-1 and the P300 wave, a schizophrenia endophenotype. Methods: Participants were 64 patients with DSM-IV schizophrenia or schizoaffective disorder, 97 of their non psychotic relatives and 35 unrelated controls. The P300 wave was extracted from the electroencephalogram whilst the subjects conducted a two-tone discrimination task. The effect of three markers from the core NRG-1 at-risk haplotype including single nucleotide polymorphism SNP8NRG221533 and two microsatellites (478B14-848 and 420M9-1395) on P300 amplitude and latency was examined using multilevel modelling. Results: Neuregulin-1 SNP8NRG221533 had a significant influence on P300 latency and the higher the number of C alleles carried, the greater the latency delay [Coef. = 32.4 ms; 95%CI: 13.2 to 51.6 ms; p = 0.001]. There was no association between latency and NRG1 microsatellites or between amplitude and any of the three markers examined. Conclusions: The P300 latency reflects the speed of neural transmission. We hypothesise that variation in NRG1 may convey risk for schizophrenia by disrupting neural connectivity, possibly white matter integrity, and leading to a slower speed of cognitive processing. This is a preliminary finding in a small sample and requires replication. © 2008 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59716
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
Funding AgencyGrant Number
Wellcome Trust
Schizophrenia Research Fund
National Alliance for Research on Schizophrenia and Depression
British Medical Association
Psychiatry Research Trust
National Institute for Health Research UK
Funding Information:

This study was funded by The Wellcome Trust, The Schizophrenia Research Fund, The National Alliance for Research on Schizophrenia and Depression, The British Medical Association and The Psychiatry Research Trust. E. Bramon was supported by a research training fellowship from The Wellcome Trust, a NARSAD voting investigator award and a post-doctoral fellowship from the National Institute for Health Research UK. These sponsors had no further role in study design; in the collection. analysis and interpretation of data; in the writing of the manuscript and in the decision to submit the paper for publication.

References

 

DC FieldValueLanguage
dc.contributor.authorBramon, Een_HK
dc.contributor.authorDempster, Een_HK
dc.contributor.authorFrangou, Sen_HK
dc.contributor.authorShaikh, Men_HK
dc.contributor.authorWalshe, Men_HK
dc.contributor.authorFilbey, FMen_HK
dc.contributor.authorMcDonald, Cen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorCollier, DAen_HK
dc.contributor.authorMurray, Ren_HK
dc.date.accessioned2010-05-31T03:55:59Z-
dc.date.available2010-05-31T03:55:59Z-
dc.date.issued2008en_HK
dc.identifier.citationSchizophrenia Research, 2008, v. 103 n. 1-3, p. 178-185en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59716-
dc.description.abstractObjective: Neuregulin-1 (NRG1) has been put forward as a susceptibility gene for schizophrenia. We investigated the association between Neuregulin-1 and the P300 wave, a schizophrenia endophenotype. Methods: Participants were 64 patients with DSM-IV schizophrenia or schizoaffective disorder, 97 of their non psychotic relatives and 35 unrelated controls. The P300 wave was extracted from the electroencephalogram whilst the subjects conducted a two-tone discrimination task. The effect of three markers from the core NRG-1 at-risk haplotype including single nucleotide polymorphism SNP8NRG221533 and two microsatellites (478B14-848 and 420M9-1395) on P300 amplitude and latency was examined using multilevel modelling. Results: Neuregulin-1 SNP8NRG221533 had a significant influence on P300 latency and the higher the number of C alleles carried, the greater the latency delay [Coef. = 32.4 ms; 95%CI: 13.2 to 51.6 ms; p = 0.001]. There was no association between latency and NRG1 microsatellites or between amplitude and any of the three markers examined. Conclusions: The P300 latency reflects the speed of neural transmission. We hypothesise that variation in NRG1 may convey risk for schizophrenia by disrupting neural connectivity, possibly white matter integrity, and leading to a slower speed of cognitive processing. This is a preliminary finding in a small sample and requires replication. © 2008 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.subject.meshEvent-Related Potentials, P300 - genetics - physiology-
dc.subject.meshNerve Tissue Proteins - genetics-
dc.subject.meshPhenotype-
dc.subject.meshPsychotic Disorders - diagnosis - genetics - physiopathology-
dc.subject.meshSchizophrenia - diagnosis - genetics - physiopathology-
dc.titleNeuregulin-1 and the P300 waveform-A preliminary association study using a psychosis endophenotypeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0920-9964&volume=103&spage=178&epage=185&date=2008&atitle=Neuregulin-1+and+the+P300+waveform-A+preliminary+association+study+using+a+psychosis+endophenotypeen_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.schres.2008.03.025en_HK
dc.identifier.pmid18571900en_HK
dc.identifier.scopuseid_2-s2.0-47249153452en_HK
dc.identifier.hkuros162572en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-47249153452&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume103en_HK
dc.identifier.issue1-3en_HK
dc.identifier.spage178en_HK
dc.identifier.epage185en_HK
dc.identifier.isiWOS:000258481500022-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK
dc.identifier.scopusauthoridDempster, E=8414816000en_HK
dc.identifier.scopusauthoridFrangou, S=7004549374en_HK
dc.identifier.scopusauthoridShaikh, M=24377053800en_HK
dc.identifier.scopusauthoridWalshe, M=8855469300en_HK
dc.identifier.scopusauthoridFilbey, FM=13606061900en_HK
dc.identifier.scopusauthoridMcDonald, C=8749594800en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridCollier, DA=26642980600en_HK
dc.identifier.scopusauthoridMurray, R=35406239400en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats