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Article: Brain morphometry volume in autistic spectrum disorder: A magnetic resonance imaging study of adults

TitleBrain morphometry volume in autistic spectrum disorder: A magnetic resonance imaging study of adults
Authors
KeywordsAsperger's syndrome
Autism spectrum disorder
Brain
Magnetic resonance imaging
Issue Date2009
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2009, v. 39 n. 2, p. 337-346 How to Cite?
AbstractBackground Several prior reports have found that some young children with autism spectrum disorder [ASD; including autism and Asperger's syndrome and pervasive developmental disorder-not otherwise specified (PDD-NOS)] have a significant increase in head size and brain weight. However, the findings from older children and adults with ASD are inconsistent. This may reflect the relatively small sample sizes that were studied, clinical heterogeneity, or age-related brain differences.Method Hence, we measured head size (intracranial volume), and the bulk volume of ventricular and peripheral cerebrospinal fluid (CSF), lobar brain, and cerebellum in 114 people with ASD and 60 controls aged between 18 and 58 years. The ASD sample included 80 people with Asperger's syndrome, 28 with autism and six with PDD-NOS.Results There was no significant between-group difference in head and/or lobar brain matter volume. However, compared with controls, each ASD subgroup had a significantly smaller cerebellar volume, and a significantly larger volume of peripheral CSF.Conclusions Within ASD adults, the bulk volume of cerebellum is reduced irrespective of diagnostic subcategory. Also the significant increase in peripheral CSF may reflect differences in cortical maturation and/or ageing. © 2008 Cambridge University Press.
Persistent Identifierhttp://hdl.handle.net/10722/59707
ISSN
2015 Impact Factor: 5.491
2015 SCImago Journal Rankings: 2.843
ISI Accession Number ID
Funding AgencyGrant Number
MRC UK A.I.M.S. network
Funding Information:

This work was supported by the MRC UK A.I.M.S. network.

 

DC FieldValueLanguage
dc.contributor.authorHallahan, Ben_HK
dc.contributor.authorDaly, EMen_HK
dc.contributor.authorMcAlonan, Gen_HK
dc.contributor.authorLoth, Een_HK
dc.contributor.authorToal, Fen_HK
dc.contributor.authorO'Brien, Fen_HK
dc.contributor.authorRobertson, Den_HK
dc.contributor.authorHales, Sen_HK
dc.contributor.authorMurphy, Cen_HK
dc.contributor.authorMurphy, KCen_HK
dc.contributor.authorMurphy, DGMen_HK
dc.date.accessioned2010-05-31T03:55:48Z-
dc.date.available2010-05-31T03:55:48Z-
dc.date.issued2009en_HK
dc.identifier.citationPsychological Medicine, 2009, v. 39 n. 2, p. 337-346en_HK
dc.identifier.issn0033-2917en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59707-
dc.description.abstractBackground Several prior reports have found that some young children with autism spectrum disorder [ASD; including autism and Asperger's syndrome and pervasive developmental disorder-not otherwise specified (PDD-NOS)] have a significant increase in head size and brain weight. However, the findings from older children and adults with ASD are inconsistent. This may reflect the relatively small sample sizes that were studied, clinical heterogeneity, or age-related brain differences.Method Hence, we measured head size (intracranial volume), and the bulk volume of ventricular and peripheral cerebrospinal fluid (CSF), lobar brain, and cerebellum in 114 people with ASD and 60 controls aged between 18 and 58 years. The ASD sample included 80 people with Asperger's syndrome, 28 with autism and six with PDD-NOS.Results There was no significant between-group difference in head and/or lobar brain matter volume. However, compared with controls, each ASD subgroup had a significantly smaller cerebellar volume, and a significantly larger volume of peripheral CSF.Conclusions Within ASD adults, the bulk volume of cerebellum is reduced irrespective of diagnostic subcategory. Also the significant increase in peripheral CSF may reflect differences in cortical maturation and/or ageing. © 2008 Cambridge University Press.en_HK
dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_HK
dc.relation.ispartofPsychological Medicineen_HK
dc.subjectAsperger's syndromeen_HK
dc.subjectAutism spectrum disorderen_HK
dc.subjectBrainen_HK
dc.subjectMagnetic resonance imagingen_HK
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAutistic Disorder - cerebrospinal fluid - diagnosis-
dc.subject.meshBrain - anatomy and histology-
dc.subject.meshMagnetic Resonance Imaging-
dc.titleBrain morphometry volume in autistic spectrum disorder: A magnetic resonance imaging study of adultsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0033-2917&volume=39 &issue=2&spage=337&epage=346&date=2009&atitle=Brain+morphometry+volume+in+autistic+spectrum+disorder:+a+magnetic+resonance+imaging+study+of+adultsen_HK
dc.identifier.emailMcAlonan, G: mcalonan@hkucc.hku.hken_HK
dc.identifier.authorityMcAlonan, G=rp00475en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1017/S0033291708003383en_HK
dc.identifier.pmid18775096-
dc.identifier.scopuseid_2-s2.0-64849102746en_HK
dc.identifier.hkuros162802en_HK
dc.identifier.volume39en_HK
dc.identifier.issue2en_HK
dc.identifier.spage337en_HK
dc.identifier.epage346en_HK
dc.identifier.isiWOS:000263402200015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHallahan, B=6603486561en_HK
dc.identifier.scopusauthoridDaly, EM=7101990804en_HK
dc.identifier.scopusauthoridMcAlonan, G=6603123011en_HK
dc.identifier.scopusauthoridLoth, E=23766871300en_HK
dc.identifier.scopusauthoridToal, F=14010549900en_HK
dc.identifier.scopusauthoridO'Brien, F=7005950721en_HK
dc.identifier.scopusauthoridRobertson, D=7402818571en_HK
dc.identifier.scopusauthoridHales, S=37113570000en_HK
dc.identifier.scopusauthoridMurphy, C=7401764127en_HK
dc.identifier.scopusauthoridMurphy, KC=7402863717en_HK
dc.identifier.scopusauthoridMurphy, DGM=7404062227en_HK
dc.identifier.citeulike4163427-

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