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Article: DSM-IV combined type ADHD shows familial association with sibling trait scores: A sampling strategy for QTL linkage

TitleDSM-IV combined type ADHD shows familial association with sibling trait scores: A sampling strategy for QTL linkage
Authors
KeywordsAttention deficit hyperactivity disorder (ADHD)
DF analysis
Linkage study
Quantitative genetics
Quantitative trait locus (QTL)
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1
Citation
American Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2008, v. 147 n. 8, p. 1450-1460 How to Cite?
Abstract
Attention deficit hyperactivity disorder (ADHD) is a discrete clinical syndrome characterized by the triad of inattention, hyperactivity, and impulsivity in the context of marked impairments. Molecular genetic studies have been successful in identifying genetic variants associated with ADHD, particularly with DSM-IV inattentive and combined subtypes. Quantitative trait locus (QTL) approaches to linkage and association mapping have yet to be widely used in ADHD research, although twin studies investigating individual differences suggest that genetic liability for ADHD is continuously distributedthroughout the population, underscoring the applicability of quantitative dimensional approaches. To investigate the appropriateness of QTL approaches, we tested the familial association between 894 probands with a research diagnosis of DSM-IV ADHD combined type and continuous trait measures among 1,135 of their siblings unselected for phenotype. The sibling recurrence rate for ADHD combined subtype was 12.7%, yielding a sibling recurrence risk ratio (λsib) of 9.0. Estimated sibling correlations around 0.2-0.3 are similar to those estimated from the analysis of fraternal twins in population twin samples. We further show that there are no threshold effects on the sibling risk for ADHD among the ADHD probands; and that both affected and unaffected siblings contributed to the association with ADHD trait scores. In conclusion, these data confirm the main requirement for QTL mapping of ADHD by demonstrating that narrowly defined DSM-IV combined type probands show familial association with dimensional ADHD symptom scores amongst their siblings. © 2008 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/59698
ISSN
2013 SCImago Journal Rankings: 1.676
ISI Accession Number ID
Funding AgencyGrant Number
NIMHR01MH062873
Funding Information:

This work was funded by NIMH Grant R01MH062873 to Stephen V. Faraone.

References

 

Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Geha Mental Health Center
  3. King's College London
  4. Trinity College Dublin
  5. Academic Medical Centre, University of Amsterdam
  6. Universiteit Gent
  7. University of Southampton
  8. Center for Child and Adolescent Psychiatry
  9. Universitair Medisch Centrum Groningen
  10. Universität Göttingen
  11. Herzog Hospital Jerusalem
  12. BAVO-Europoort
  13. Universitat de Valencia
  14. Zentralinstitut für Seelische Gesundheit
  15. Hospital Universitario La Fe
  16. Universitäts Klinikum Essen und Medizinische Fakultät
  17. Vrije Universiteit Amsterdam
  18. Radboud University Nijmegen Medical Centre
  19. Shaare Zedek Medical Center
  20. Universität Zürich
  21. State University of New York Upstate Medical University
DC FieldValueLanguage
dc.contributor.authorChen, Wen_HK
dc.contributor.authorZhou, Ken_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorFranke, Ben_HK
dc.contributor.authorKuntsi, Jen_HK
dc.contributor.authorCampbell, Den_HK
dc.contributor.authorFleischman, Ken_HK
dc.contributor.authorKnight, Jen_HK
dc.contributor.authorAndreou, Pen_HK
dc.contributor.authorArnold, Ren_HK
dc.contributor.authorAltink, Men_HK
dc.contributor.authorBoer, Fen_HK
dc.contributor.authorBoholst, MJen_HK
dc.contributor.authorBuschgens, Cen_HK
dc.contributor.authorButler, Len_HK
dc.contributor.authorChristiansen, Hen_HK
dc.contributor.authorFliers, Een_HK
dc.contributor.authorHoweForbes, Ren_HK
dc.contributor.authorGabriëls, Ien_HK
dc.contributor.authorHeise, Aen_HK
dc.contributor.authorKornLubetzki, Ien_HK
dc.contributor.authorMarco, Ren_HK
dc.contributor.authorMedad, Sen_HK
dc.contributor.authorMinderaa, Ren_HK
dc.contributor.authorMüller, UCen_HK
dc.contributor.authorMulligan, Aen_HK
dc.contributor.authorPsychogiou, Len_HK
dc.contributor.authorRommelse, Nen_HK
dc.contributor.authorSethna, Ven_HK
dc.contributor.authorUebel, Hen_HK
dc.contributor.authorMcGuffin, Pen_HK
dc.contributor.authorPlomin, Ren_HK
dc.contributor.authorBanaschewski, Ten_HK
dc.contributor.authorBuitelaar, Jen_HK
dc.contributor.authorEbstein, Ren_HK
dc.contributor.authorEisenberg, Jen_HK
dc.contributor.authorGill, Men_HK
dc.contributor.authorManor, Ien_HK
dc.contributor.authorMiranda, Aen_HK
dc.contributor.authorMulas, Fen_HK
dc.contributor.authorOades, RDen_HK
dc.contributor.authorRoeyers, Hen_HK
dc.contributor.authorRothenberger, Aen_HK
dc.contributor.authorSergeant, Jen_HK
dc.contributor.authorSonugaBarke, Een_HK
dc.contributor.authorSteinhausen, HCen_HK
dc.contributor.authorTaylor, Een_HK
dc.contributor.authorThompson, Men_HK
dc.contributor.authorFaraone, SVen_HK
dc.contributor.authorAsherson, Pen_HK
dc.date.accessioned2010-05-31T03:55:38Z-
dc.date.available2010-05-31T03:55:38Z-
dc.date.issued2008en_HK
dc.identifier.citationAmerican Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2008, v. 147 n. 8, p. 1450-1460en_HK
dc.identifier.issn1552-485Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/59698-
dc.description.abstractAttention deficit hyperactivity disorder (ADHD) is a discrete clinical syndrome characterized by the triad of inattention, hyperactivity, and impulsivity in the context of marked impairments. Molecular genetic studies have been successful in identifying genetic variants associated with ADHD, particularly with DSM-IV inattentive and combined subtypes. Quantitative trait locus (QTL) approaches to linkage and association mapping have yet to be widely used in ADHD research, although twin studies investigating individual differences suggest that genetic liability for ADHD is continuously distributedthroughout the population, underscoring the applicability of quantitative dimensional approaches. To investigate the appropriateness of QTL approaches, we tested the familial association between 894 probands with a research diagnosis of DSM-IV ADHD combined type and continuous trait measures among 1,135 of their siblings unselected for phenotype. The sibling recurrence rate for ADHD combined subtype was 12.7%, yielding a sibling recurrence risk ratio (λsib) of 9.0. Estimated sibling correlations around 0.2-0.3 are similar to those estimated from the analysis of fraternal twins in population twin samples. We further show that there are no threshold effects on the sibling risk for ADHD among the ADHD probands; and that both affected and unaffected siblings contributed to the association with ADHD trait scores. In conclusion, these data confirm the main requirement for QTL mapping of ADHD by demonstrating that narrowly defined DSM-IV combined type probands show familial association with dimensional ADHD symptom scores amongst their siblings. © 2008 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1en_HK
dc.relation.ispartofAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Geneticsen_HK
dc.rightsAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectAttention deficit hyperactivity disorder (ADHD)en_HK
dc.subjectDF analysisen_HK
dc.subjectLinkage studyen_HK
dc.subjectQuantitative geneticsen_HK
dc.subjectQuantitative trait locus (QTL)en_HK
dc.titleDSM-IV combined type ADHD shows familial association with sibling trait scores: A sampling strategy for QTL linkageen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1552-4841&volume=147B&spage=1450&epage=1460&date=2008&atitle=DSM-IV+Combined+Type+ADHD+Shows+Familial+Association+With+Sibling+Trait+Scores:+A+Sampling+Strategy+For+QTL+Linkageen_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ajmg.b.30672en_HK
dc.identifier.pmid18189238en_HK
dc.identifier.scopuseid_2-s2.0-57349174136en_HK
dc.identifier.hkuros162575en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-57349174136&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume147en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1450en_HK
dc.identifier.epage1460en_HK
dc.identifier.isiWOS:000261415800018-
dc.identifier.scopusauthoridChen, W=35975528400en_HK
dc.identifier.scopusauthoridZhou, K=22837296400en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridFranke, B=7005326255en_HK
dc.identifier.scopusauthoridKuntsi, J=6603162889en_HK
dc.identifier.scopusauthoridCampbell, D=16041366500en_HK
dc.identifier.scopusauthoridFleischman, K=14719313200en_HK
dc.identifier.scopusauthoridKnight, J=13002769800en_HK
dc.identifier.scopusauthoridAndreou, P=14719214000en_HK
dc.identifier.scopusauthoridArnold, R=14718900200en_HK
dc.identifier.scopusauthoridAltink, M=22033878600en_HK
dc.identifier.scopusauthoridBoer, F=7003775900en_HK
dc.identifier.scopusauthoridBoholst, MJ=36484041600en_HK
dc.identifier.scopusauthoridBuschgens, C=14718883900en_HK
dc.identifier.scopusauthoridButler, L=24467528500en_HK
dc.identifier.scopusauthoridChristiansen, H=8954661000en_HK
dc.identifier.scopusauthoridFliers, E=8654609300en_HK
dc.identifier.scopusauthoridHoweForbes, R=14719347000en_HK
dc.identifier.scopusauthoridGabriëls, I=24072954900en_HK
dc.identifier.scopusauthoridHeise, A=7006439396en_HK
dc.identifier.scopusauthoridKornLubetzki, I=7003302930en_HK
dc.identifier.scopusauthoridMarco, R=23392905500en_HK
dc.identifier.scopusauthoridMedad, S=15124570000en_HK
dc.identifier.scopusauthoridMinderaa, R=7004542584en_HK
dc.identifier.scopusauthoridMüller, UC=12242861600en_HK
dc.identifier.scopusauthoridMulligan, A=23570979700en_HK
dc.identifier.scopusauthoridPsychogiou, L=22635632800en_HK
dc.identifier.scopusauthoridRommelse, N=14720195600en_HK
dc.identifier.scopusauthoridSethna, V=10738884700en_HK
dc.identifier.scopusauthoridUebel, H=22982364200en_HK
dc.identifier.scopusauthoridMcGuffin, P=22954119700en_HK
dc.identifier.scopusauthoridPlomin, R=36050187200en_HK
dc.identifier.scopusauthoridBanaschewski, T=6603935963en_HK
dc.identifier.scopusauthoridBuitelaar, J=26640178500en_HK
dc.identifier.scopusauthoridEbstein, R=7007152650en_HK
dc.identifier.scopusauthoridEisenberg, J=7102686191en_HK
dc.identifier.scopusauthoridGill, M=35228962600en_HK
dc.identifier.scopusauthoridManor, I=6701576599en_HK
dc.identifier.scopusauthoridMiranda, A=35403188200en_HK
dc.identifier.scopusauthoridMulas, F=7004054009en_HK
dc.identifier.scopusauthoridOades, RD=7006782221en_HK
dc.identifier.scopusauthoridRoeyers, H=6701645061en_HK
dc.identifier.scopusauthoridRothenberger, A=7005835367en_HK
dc.identifier.scopusauthoridSergeant, J=7004036780en_HK
dc.identifier.scopusauthoridSonugaBarke, E=7005682785en_HK
dc.identifier.scopusauthoridSteinhausen, HC=7102832892en_HK
dc.identifier.scopusauthoridTaylor, E=7403206584en_HK
dc.identifier.scopusauthoridThompson, M=14526195300en_HK
dc.identifier.scopusauthoridFaraone, SV=36047714700en_HK
dc.identifier.scopusauthoridAsherson, P=35402700900en_HK
dc.identifier.citeulike10600645-

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