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Article: DSM-IV combined type ADHD shows familial association with sibling trait scores: A sampling strategy for QTL linkage
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TitleDSM-IV combined type ADHD shows familial association with sibling trait scores: A sampling strategy for QTL linkage
 
AuthorsChen, W3
Zhou, K3
Sham, P1 3
Franke, B18
Kuntsi, J3
Campbell, D3
Fleischman, K3
Knight, J3
Andreou, P3
Arnold, R8
Altink, M18
Boer, F5
Boholst, MJ3
Buschgens, C18
Butler, L4
Christiansen, H16
Fliers, E12 18
HoweForbes, R3
Gabriëls, I6
Heise, A10
KornLubetzki, I19
Marco, R13
Medad, S2
Minderaa, R9
Müller, UC20
Mulligan, A4
Psychogiou, L7
Rommelse, N17
Sethna, V3
Uebel, H10
McGuffin, P3
Plomin, R3
Banaschewski, T10 14
Buitelaar, J18
Ebstein, R11
Eisenberg, J11
Gill, M4
Manor, I2
Miranda, A13
Mulas, F15
Oades, RD16
Roeyers, H6
Rothenberger, A10
Sergeant, J17
SonugaBarke, E7
Steinhausen, HC20
Taylor, E3
Thompson, M7
Faraone, SV21
Asherson, P3
 
KeywordsAttention deficit hyperactivity disorder (ADHD)
DF analysis
Linkage study
Quantitative genetics
Quantitative trait locus (QTL)
 
Issue Date2008
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1
 
CitationAmerican Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2008, v. 147 n. 8, p. 1450-1460 [How to Cite?]
DOI: http://dx.doi.org/10.1002/ajmg.b.30672
 
AbstractAttention deficit hyperactivity disorder (ADHD) is a discrete clinical syndrome characterized by the triad of inattention, hyperactivity, and impulsivity in the context of marked impairments. Molecular genetic studies have been successful in identifying genetic variants associated with ADHD, particularly with DSM-IV inattentive and combined subtypes. Quantitative trait locus (QTL) approaches to linkage and association mapping have yet to be widely used in ADHD research, although twin studies investigating individual differences suggest that genetic liability for ADHD is continuously distributedthroughout the population, underscoring the applicability of quantitative dimensional approaches. To investigate the appropriateness of QTL approaches, we tested the familial association between 894 probands with a research diagnosis of DSM-IV ADHD combined type and continuous trait measures among 1,135 of their siblings unselected for phenotype. The sibling recurrence rate for ADHD combined subtype was 12.7%, yielding a sibling recurrence risk ratio (λsib) of 9.0. Estimated sibling correlations around 0.2-0.3 are similar to those estimated from the analysis of fraternal twins in population twin samples. We further show that there are no threshold effects on the sibling risk for ADHD among the ADHD probands; and that both affected and unaffected siblings contributed to the association with ADHD trait scores. In conclusion, these data confirm the main requirement for QTL mapping of ADHD by demonstrating that narrowly defined DSM-IV combined type probands show familial association with dimensional ADHD symptom scores amongst their siblings. © 2008 Wiley-Liss, Inc.
 
ISSN1552-485X
2012 SCImago Journal Rankings: 1.406
 
DOIhttp://dx.doi.org/10.1002/ajmg.b.30672
 
ISI Accession Number IDWOS:000261415800018
Funding AgencyGrant Number
NIMHR01MH062873
Funding Information:

This work was funded by NIMH Grant R01MH062873 to Stephen V. Faraone.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChen, W
 
dc.contributor.authorZhou, K
 
dc.contributor.authorSham, P
 
dc.contributor.authorFranke, B
 
dc.contributor.authorKuntsi, J
 
dc.contributor.authorCampbell, D
 
dc.contributor.authorFleischman, K
 
dc.contributor.authorKnight, J
 
dc.contributor.authorAndreou, P
 
dc.contributor.authorArnold, R
 
dc.contributor.authorAltink, M
 
dc.contributor.authorBoer, F
 
dc.contributor.authorBoholst, MJ
 
dc.contributor.authorBuschgens, C
 
dc.contributor.authorButler, L
 
dc.contributor.authorChristiansen, H
 
dc.contributor.authorFliers, E
 
dc.contributor.authorHoweForbes, R
 
dc.contributor.authorGabriëls, I
 
dc.contributor.authorHeise, A
 
dc.contributor.authorKornLubetzki, I
 
dc.contributor.authorMarco, R
 
dc.contributor.authorMedad, S
 
dc.contributor.authorMinderaa, R
 
dc.contributor.authorMüller, UC
 
dc.contributor.authorMulligan, A
 
dc.contributor.authorPsychogiou, L
 
dc.contributor.authorRommelse, N
 
dc.contributor.authorSethna, V
 
dc.contributor.authorUebel, H
 
dc.contributor.authorMcGuffin, P
 
dc.contributor.authorPlomin, R
 
dc.contributor.authorBanaschewski, T
 
dc.contributor.authorBuitelaar, J
 
dc.contributor.authorEbstein, R
 
dc.contributor.authorEisenberg, J
 
dc.contributor.authorGill, M
 
dc.contributor.authorManor, I
 
dc.contributor.authorMiranda, A
 
dc.contributor.authorMulas, F
 
dc.contributor.authorOades, RD
 
dc.contributor.authorRoeyers, H
 
dc.contributor.authorRothenberger, A
 
dc.contributor.authorSergeant, J
 
dc.contributor.authorSonugaBarke, E
 
dc.contributor.authorSteinhausen, HC
 
dc.contributor.authorTaylor, E
 
dc.contributor.authorThompson, M
 
dc.contributor.authorFaraone, SV
 
dc.contributor.authorAsherson, P
 
dc.date.accessioned2010-05-31T03:55:38Z
 
dc.date.available2010-05-31T03:55:38Z
 
dc.date.issued2008
 
dc.description.abstractAttention deficit hyperactivity disorder (ADHD) is a discrete clinical syndrome characterized by the triad of inattention, hyperactivity, and impulsivity in the context of marked impairments. Molecular genetic studies have been successful in identifying genetic variants associated with ADHD, particularly with DSM-IV inattentive and combined subtypes. Quantitative trait locus (QTL) approaches to linkage and association mapping have yet to be widely used in ADHD research, although twin studies investigating individual differences suggest that genetic liability for ADHD is continuously distributedthroughout the population, underscoring the applicability of quantitative dimensional approaches. To investigate the appropriateness of QTL approaches, we tested the familial association between 894 probands with a research diagnosis of DSM-IV ADHD combined type and continuous trait measures among 1,135 of their siblings unselected for phenotype. The sibling recurrence rate for ADHD combined subtype was 12.7%, yielding a sibling recurrence risk ratio (λsib) of 9.0. Estimated sibling correlations around 0.2-0.3 are similar to those estimated from the analysis of fraternal twins in population twin samples. We further show that there are no threshold effects on the sibling risk for ADHD among the ADHD probands; and that both affected and unaffected siblings contributed to the association with ADHD trait scores. In conclusion, these data confirm the main requirement for QTL mapping of ADHD by demonstrating that narrowly defined DSM-IV combined type probands show familial association with dimensional ADHD symptom scores amongst their siblings. © 2008 Wiley-Liss, Inc.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationAmerican Journal Of Medical Genetics, Part B: Neuropsychiatric Genetics, 2008, v. 147 n. 8, p. 1450-1460 [How to Cite?]
DOI: http://dx.doi.org/10.1002/ajmg.b.30672
 
dc.identifier.citeulike10600645
 
dc.identifier.doihttp://dx.doi.org/10.1002/ajmg.b.30672
 
dc.identifier.epage1460
 
dc.identifier.hkuros162575
 
dc.identifier.isiWOS:000261415800018
Funding AgencyGrant Number
NIMHR01MH062873
Funding Information:

This work was funded by NIMH Grant R01MH062873 to Stephen V. Faraone.

 
dc.identifier.issn1552-485X
2012 SCImago Journal Rankings: 1.406
 
dc.identifier.issue8
 
dc.identifier.openurl
 
dc.identifier.pmid18189238
 
dc.identifier.scopuseid_2-s2.0-57349174136
 
dc.identifier.spage1450
 
dc.identifier.urihttp://hdl.handle.net/10722/59698
 
dc.identifier.volume147
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0148-7299:1
 
dc.relation.ispartofAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
 
dc.relation.referencesReferences in Scopus
 
dc.rightsAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics. Copyright © John Wiley & Sons, Inc.
 
dc.subjectAttention deficit hyperactivity disorder (ADHD)
 
dc.subjectDF analysis
 
dc.subjectLinkage study
 
dc.subjectQuantitative genetics
 
dc.subjectQuantitative trait locus (QTL)
 
dc.titleDSM-IV combined type ADHD shows familial association with sibling trait scores: A sampling strategy for QTL linkage
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Geha Mental Health Center
  3. King's College London
  4. Trinity College Dublin
  5. Academic Medical Centre, University of Amsterdam
  6. Universiteit Gent
  7. University of Southampton
  8. Center for Child and Adolescent Psychiatry
  9. Universitair Medisch Centrum Groningen
  10. Universität Göttingen
  11. Herzog Hospital Jerusalem
  12. BAVO-Europoort
  13. Universitat de Valencia
  14. Zentralinstitut für Seelische Gesundheit
  15. Hospital Universitario La Fe
  16. Universitäts Klinikum Essen und Medizinische Fakultät
  17. Vrije Universiteit Amsterdam
  18. Radboud University Nijmegen Medical Centre
  19. Shaare Zedek Medical Center
  20. Universität Zürich
  21. State University of New York Upstate Medical University