Article: Abnormal spatiotemporal processing of emotional facial expressions in childhood autism: Dipole source analysis of event-related potentials

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- Dr Chua, Siew Eng
- Dr McAlonan, Grainne Mary

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Publisher Website: 10.1111/j.1460-9568.2008.06328.x
Scopus: eid_2-s2.0-48349105168
PMID: 18702712
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Title	Abnormal spatiotemporal processing of emotional facial expressions in childhood autism: Dipole source analysis of event-related potentials
Authors	Wong, TKW1 Fung, PCW1 Chua, SE1 McAlonan, GM1
Keywords	BESA Brain Electroencephalography Emotion Faces
Issue Date	2008
Publisher	Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJN
Citation	European Journal Of Neuroscience, 2008, v. 28 n. 2, p. 407-416 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1460-9568.2008.06328.x
Abstract	Previous studies of face processing in autism suggest abnormalities in anatomical development, functioning and connectivity/coordination of distributed brain systems involved in social cognition, but the spatial sequence and time course of rapid (sub-second) neural responses to emotional facial expressions have not been examined in detail. Source analysis of high-density event-related potentials (ERPs) is an optimal means to examine both the precise temporal profile and spatial location of early electrical brain activity in response to emotionally salient stimuli. Therefore, we recorded 128-channel ERPs from high-functioning males with autism (aged 6-10 years), and age-, sex- and IQ-matched typically developing controls during explicit and implicit processing of emotion from pictures showing happy, angry, fearful, sad and neutral facial expressions. Children with autism showed normal patterns of behavioural and ERP (P1, N170 and P2) responses. However, dipole source analysis revealed that ERP responses relating to face detection (visual cortex) and configural processing of faces (fusiform gyrus), as well as mental state decoding (medial prefrontal lobe), were significantly weaker and/or slower in autism compared with controls during both explicit and implicit emotion-processing tasks. Slower- and larger-amplitude ERP source activity in the parietal somatosensory cortices possibly reflected more effortful compensatory analytical strategies used by the autism group to process facial gender and emotion. Such aberrant neurophysiological processing of facial emotion observed in children with autism within the first 300 ms of stimulus presentation suggests abnormal cortical specialization within social brain networks, which would likely disrupt the development of normal social-cognitive skills. © The Authors (2008).
ISSN	0953-816X 2011 Impact Factor: 3.631 2011 SCImago Journal Rankings: 0.359
DOI	http://dx.doi.org/10.1111/j.1460-9568.2008.06328.x
ISI Accession Number ID	WOS:000257715800018
References	References in Scopus

DC Field	Value
dc.contributor.author	Wong, TKW
dc.contributor.author	Fung, PCW
dc.contributor.author	Chua, SE
dc.contributor.author	McAlonan, GM
dc.date.accessioned	2010-05-31T03:55:31Z
dc.date.available	2010-05-31T03:55:31Z
dc.date.issued	2008
dc.description.abstract	Previous studies of face processing in autism suggest abnormalities in anatomical development, functioning and connectivity/coordination of distributed brain systems involved in social cognition, but the spatial sequence and time course of rapid (sub-second) neural responses to emotional facial expressions have not been examined in detail. Source analysis of high-density event-related potentials (ERPs) is an optimal means to examine both the precise temporal profile and spatial location of early electrical brain activity in response to emotionally salient stimuli. Therefore, we recorded 128-channel ERPs from high-functioning males with autism (aged 6-10 years), and age-, sex- and IQ-matched typically developing controls during explicit and implicit processing of emotion from pictures showing happy, angry, fearful, sad and neutral facial expressions. Children with autism showed normal patterns of behavioural and ERP (P1, N170 and P2) responses. However, dipole source analysis revealed that ERP responses relating to face detection (visual cortex) and configural processing of faces (fusiform gyrus), as well as mental state decoding (medial prefrontal lobe), were significantly weaker and/or slower in autism compared with controls during both explicit and implicit emotion-processing tasks. Slower- and larger-amplitude ERP source activity in the parietal somatosensory cortices possibly reflected more effortful compensatory analytical strategies used by the autism group to process facial gender and emotion. Such aberrant neurophysiological processing of facial emotion observed in children with autism within the first 300 ms of stimulus presentation suggests abnormal cortical specialization within social brain networks, which would likely disrupt the development of normal social-cognitive skills. © The Authors (2008).
dc.description.nature	Link_to_subscribed_fulltext
dc.identifier.citation	European Journal Of Neuroscience, 2008, v. 28 n. 2, p. 407-416 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1460-9568.2008.06328.x
dc.identifier.citeulike	3020828
dc.identifier.doi	http://dx.doi.org/10.1111/j.1460-9568.2008.06328.x
dc.identifier.epage	416
dc.identifier.hkuros	146623
dc.identifier.isi	WOS:000257715800018
dc.identifier.issn	0953-816X 2011 Impact Factor: 3.631 2011 SCImago Journal Rankings: 0.359
dc.identifier.issue	2
dc.identifier.openurl
dc.identifier.pmid	18702712
dc.identifier.scopus	eid_2-s2.0-48349105168
dc.identifier.spage	407
dc.identifier.uri	http://hdl.handle.net/10722/59693
dc.identifier.volume	28
dc.language	eng
dc.publisher	Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJN
dc.publisher.place	United Kingdom
dc.relation.ispartof	European Journal of Neuroscience
dc.relation.references	References in Scopus
dc.rights	European Journal of Neuroscience. Copyright © Blackwell Publishing Ltd.
dc.subject	BESA
dc.subject	Brain
dc.subject	Electroencephalography
dc.subject	Emotion
dc.subject	Faces
dc.title	Abnormal spatiotemporal processing of emotional facial expressions in childhood autism: Dipole source analysis of event-related potentials
dc.type	Article

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The University of Hong Kong

Article: Abnormal spatiotemporal processing of emotional facial expressions in childhood autism: Dipole source analysis of event-related potentials

The HKU Scholars Hub has contact details for these author(s).