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Article: Corticofugal projection inhibits the auditory thalamus through the thalamic reticular nucleus

TitleCorticofugal projection inhibits the auditory thalamus through the thalamic reticular nucleus
Authors
Issue Date2008
PublisherAmerican Physiological Society
Citation
Journal Of Neurophysiology, 2008, v. 99 n. 6, p. 2938-2945 How to Cite?
AbstractElectrical stimulation of the auditory cortex (AC) causes both facilitatory and inhibitory effects on the medial geniculate body (MGB). The purpose of this study was to identify the corticofugal inhibitory pathway to the MGB. We assessed two potential circuits: 1) the cortico-colliculothalamic circuit and 2) cortico-reticulo-thalamic one. We compared intracellular responses of MGB neurons to electrical stimulation of the AC following bilateral ablation of the inferior colliculi (IC) or thalamic reticular nucleus (TRN) in anesthetized guinea pigs. Cortical stimulation with intact TRN could cause strong inhibitory effects on the MGB neurons. The corticofugal inhibition remained effective after bilateral IC ablation, but it was minimized after the TRN was lesioned with kainic acid. Synchronized TRN neuronal activity and MGB inhibitory postsynaptic potentials (IPSPs) were observed with multiple recordings. The results suggest that corticofugal inhibition traverses the corticoreticulothalamic pathway, indicating that the colliculi-geniculate inhibitory pathway is probably only for feedforward inhibition. Copyright © 2008 The American Physiological Society.
Persistent Identifierhttp://hdl.handle.net/10722/59671
ISSN
2015 Impact Factor: 2.653
2015 SCImago Journal Rankings: 2.230
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Zen_HK
dc.contributor.authorLiu, CHen_HK
dc.contributor.authorYu, YQen_HK
dc.contributor.authorFujimoto, Ken_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorHe, Jen_HK
dc.date.accessioned2010-05-31T03:54:57Z-
dc.date.available2010-05-31T03:54:57Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Neurophysiology, 2008, v. 99 n. 6, p. 2938-2945en_HK
dc.identifier.issn0022-3077en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59671-
dc.description.abstractElectrical stimulation of the auditory cortex (AC) causes both facilitatory and inhibitory effects on the medial geniculate body (MGB). The purpose of this study was to identify the corticofugal inhibitory pathway to the MGB. We assessed two potential circuits: 1) the cortico-colliculothalamic circuit and 2) cortico-reticulo-thalamic one. We compared intracellular responses of MGB neurons to electrical stimulation of the AC following bilateral ablation of the inferior colliculi (IC) or thalamic reticular nucleus (TRN) in anesthetized guinea pigs. Cortical stimulation with intact TRN could cause strong inhibitory effects on the MGB neurons. The corticofugal inhibition remained effective after bilateral IC ablation, but it was minimized after the TRN was lesioned with kainic acid. Synchronized TRN neuronal activity and MGB inhibitory postsynaptic potentials (IPSPs) were observed with multiple recordings. The results suggest that corticofugal inhibition traverses the corticoreticulothalamic pathway, indicating that the colliculi-geniculate inhibitory pathway is probably only for feedforward inhibition. Copyright © 2008 The American Physiological Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Physiological Societyen_HK
dc.relation.ispartofJournal of Neurophysiologyen_HK
dc.titleCorticofugal projection inhibits the auditory thalamus through the thalamic reticular nucleusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3077&volume=99&spage=2938&epage=2945&date=2008&atitle=Corticofugal+projection+inhibits+the+auditory+thalamus+through+the+thalamic+reticular+nucleusen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1152/jn.00002.2008en_HK
dc.identifier.pmid18417625-
dc.identifier.scopuseid_2-s2.0-57049113848en_HK
dc.identifier.hkuros164076en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-57049113848&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume99en_HK
dc.identifier.issue6en_HK
dc.identifier.spage2938en_HK
dc.identifier.epage2945en_HK
dc.identifier.isiWOS:000256632600020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhang, Z=23053543300en_HK
dc.identifier.scopusauthoridLiu, CH=36851827300en_HK
dc.identifier.scopusauthoridYu, YQ=7406253532en_HK
dc.identifier.scopusauthoridFujimoto, K=7403304197en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.scopusauthoridHe, J=7404984971en_HK

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