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Article: Cyclic ADP-ribose links metabolism to multiple fission in the dinoflagellate Crypthecodinium cohnii

TitleCyclic ADP-ribose links metabolism to multiple fission in the dinoflagellate Crypthecodinium cohnii
Authors
KeywordsCell cycle
Cyclic ADP-ribose
Dinoflagellates
Intracellular calcium
Metabolism
Issue Date2009
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/ceca
Citation
Cell Calcium, 2009, v. 45 n. 4, p. 346-357 How to Cite?
AbstractCellular metabolism is required for cell proliferation. However, the way in which metabolic signals are conveyed to cell cycle decisions is unclear. Cyclic ADP-ribose (cADPR), the NAD+ metabolite, mobilizes calcium from calcium stores in many cells. We found that dinoflagellate cells with higher metabolic rate underwent multiple fission (MF), a division mode in which cells can exceed twice their sizes at G1. A temperature shift-down experiment suggested that MF involves a commitment point at late G1. In fast-growing cells, cADPR level peaked in G1 and increased with increasing concentrations of glucose in the medium. Addition of glycolytic poison iodoacetate inhibited cell growth, reduced cADPR levels as well as the commitment of cell cycles in fast-growing cells. Commitment of MF cell cycles was induced by a cell permeant cADPR agonist, but blocked by a specific antagonist of cADPR-induced Ca2+ release. Our results establish cADPR as a link between cellular metabolism and cell cycle control. © 2009 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59669
ISSN
2015 Impact Factor: 2.909
2015 SCImago Journal Rankings: 1.631
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, CMCen_HK
dc.contributor.authorYeung, PKKen_HK
dc.contributor.authorLee, HCen_HK
dc.contributor.authorWong, JTYen_HK
dc.date.accessioned2010-05-31T03:54:54Z-
dc.date.available2010-05-31T03:54:54Z-
dc.date.issued2009en_HK
dc.identifier.citationCell Calcium, 2009, v. 45 n. 4, p. 346-357en_HK
dc.identifier.issn0143-4160en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59669-
dc.description.abstractCellular metabolism is required for cell proliferation. However, the way in which metabolic signals are conveyed to cell cycle decisions is unclear. Cyclic ADP-ribose (cADPR), the NAD+ metabolite, mobilizes calcium from calcium stores in many cells. We found that dinoflagellate cells with higher metabolic rate underwent multiple fission (MF), a division mode in which cells can exceed twice their sizes at G1. A temperature shift-down experiment suggested that MF involves a commitment point at late G1. In fast-growing cells, cADPR level peaked in G1 and increased with increasing concentrations of glucose in the medium. Addition of glycolytic poison iodoacetate inhibited cell growth, reduced cADPR levels as well as the commitment of cell cycles in fast-growing cells. Commitment of MF cell cycles was induced by a cell permeant cADPR agonist, but blocked by a specific antagonist of cADPR-induced Ca2+ release. Our results establish cADPR as a link between cellular metabolism and cell cycle control. © 2009 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/cecaen_HK
dc.relation.ispartofCell Calciumen_HK
dc.subjectCell cycleen_HK
dc.subjectCyclic ADP-riboseen_HK
dc.subjectDinoflagellatesen_HK
dc.subjectIntracellular calciumen_HK
dc.subjectMetabolismen_HK
dc.titleCyclic ADP-ribose links metabolism to multiple fission in the dinoflagellate Crypthecodinium cohniien_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0143-4160&volume=45&spage=346&epage=357&date=2009&atitle=Cyclic+ADP-ribose+links+metabolism+to+multiple+fission+in+the+dinoflagellate+Crypthecodinium+cohnii.en_HK
dc.identifier.emailLee, HC: leehc@hku.hken_HK
dc.identifier.authorityLee, HC=rp00545en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ceca.2008.12.006en_HK
dc.identifier.pmid19201464-
dc.identifier.scopuseid_2-s2.0-62549084244en_HK
dc.identifier.hkuros155020en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-62549084244&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume45en_HK
dc.identifier.issue4en_HK
dc.identifier.spage346en_HK
dc.identifier.epage357en_HK
dc.identifier.isiWOS:000265370500005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, CMC=26026006700en_HK
dc.identifier.scopusauthoridYeung, PKK=7006727708en_HK
dc.identifier.scopusauthoridLee, HC=26642959100en_HK
dc.identifier.scopusauthoridWong, JTY=24467064200en_HK

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