Article: Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice
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- Publisher Website: 10.1016/j.phymed.2008.10.004
- Scopus: eid_2-s2.0-64649089598
- PMID: 19109000
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| Title | Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Seto, SW4 Lam, TY4 Tam, HL3 Au, ALS4 Chan, SW3 Wu, JH3 Yu, PHF3 Leung, GPH1 Ngai, SM4 Yeung, JHK4 Leung, PS4 Lee, SMY2 Kwan, YW4 | ||||||
| Keywords | Ganoderma lucidum HMG CoA reductase PEPCK Type 2 diabetes mellitus | ||||||
| Issue Date | 2009 | ||||||
| Publisher | Urban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomed | ||||||
| Citation | Phytomedicine, 2009, v. 16 n. 5, p. 426-436 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.phymed.2008.10.004 | ||||||
| Abstract | In this study, we evaluated the pharmacological effects of Ganoderma lucidum (G. lucidum) (water-extract) (0.003, 0.03 and 0.3 g/kg, 4-week oral gavage) consumption using the lean (+db/+m) and the obese/diabetic (+db/+db) mice. Different physiological parameters (plasma glucose and insulin levels, lipoproteins-cholesterol levels, phosphoenolpyruvate carboxykinase (PEPCK), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase) and isolated aorta relaxation of both species were measured and compared. G. lucidum (0.03 and 0.3 g/kg) lowered the serum glucose level in +db/+db mice after the first week of treatment whereas a reduction was observed in +db/+m mice only fed with 0.3 g/kg of G. lucidum at the fourth week. A higher hepatic PEPCK gene expression was found in +db/+db mice. G. lucidum (0.03 and 0.3 g/kg) markedly reduced the PEPCK expression in +db/+db mice whereas the expression of PEPCK was attenuated in +db/+m mice (0.3 g/kg G. lucidum). HMG CoA reductase protein expression (in both hepatic and extra-hepatic organs) and the serum insulin level were not altered by G. lucidum. These data demonstrate that G. lucidum consumption can provide beneficial effects in treating type 2 diabetes mellitus (T2DM) by lowering the serum glucose levels through the suppression of the hepatic PEPCK gene expression. © 2008 Elsevier GmbH. All rights reserved. | ||||||
| ISSN | 0944-7113 2011 Impact Factor: 3.268 2011 SCImago Journal Rankings: 0.133 | ||||||
| DOI | http://dx.doi.org/10.1016/j.phymed.2008.10.004 | ||||||
| ISI Accession Number ID | WOS:000265952500005
Funding Information: Provision or G. lucidum (PuraLin (R))/PuraGold (R)) capsules by Dr. Kevin Chu (PuraPharm Research Corporation Ltd., Hong Kong SAR, PR China) is acknowledged. This project is financially supported by the RGC Earmarked Grants of Hong Kong SAR (Ref.: 4107/01 M and Ref.: 4166/02 M), and Direct Grants for Research (The Chinese University of Hong Kong) (Reference no.: 2401149; Project code: 2041231). | ||||||
| References | References in Scopus |
| dc.contributor.author | Seto, SW | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Lam, TY | ||||||
| dc.contributor.author | Tam, HL | ||||||
| dc.contributor.author | Au, ALS | ||||||
| dc.contributor.author | Chan, SW | ||||||
| dc.contributor.author | Wu, JH | ||||||
| dc.contributor.author | Yu, PHF | ||||||
| dc.contributor.author | Leung, GPH | ||||||
| dc.contributor.author | Ngai, SM | ||||||
| dc.contributor.author | Yeung, JHK | ||||||
| dc.contributor.author | Leung, PS | ||||||
| dc.contributor.author | Lee, SMY | ||||||
| dc.contributor.author | Kwan, YW | ||||||
| dc.date.accessioned | 2010-05-31T03:52:44Z | ||||||
| dc.date.available | 2010-05-31T03:52:44Z | ||||||
| dc.date.issued | 2009 | ||||||
| dc.description.abstract | In this study, we evaluated the pharmacological effects of Ganoderma lucidum (G. lucidum) (water-extract) (0.003, 0.03 and 0.3 g/kg, 4-week oral gavage) consumption using the lean (+db/+m) and the obese/diabetic (+db/+db) mice. Different physiological parameters (plasma glucose and insulin levels, lipoproteins-cholesterol levels, phosphoenolpyruvate carboxykinase (PEPCK), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase) and isolated aorta relaxation of both species were measured and compared. G. lucidum (0.03 and 0.3 g/kg) lowered the serum glucose level in +db/+db mice after the first week of treatment whereas a reduction was observed in +db/+m mice only fed with 0.3 g/kg of G. lucidum at the fourth week. A higher hepatic PEPCK gene expression was found in +db/+db mice. G. lucidum (0.03 and 0.3 g/kg) markedly reduced the PEPCK expression in +db/+db mice whereas the expression of PEPCK was attenuated in +db/+m mice (0.3 g/kg G. lucidum). HMG CoA reductase protein expression (in both hepatic and extra-hepatic organs) and the serum insulin level were not altered by G. lucidum. These data demonstrate that G. lucidum consumption can provide beneficial effects in treating type 2 diabetes mellitus (T2DM) by lowering the serum glucose levels through the suppression of the hepatic PEPCK gene expression. © 2008 Elsevier GmbH. All rights reserved. | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Phytomedicine, 2009, v. 16 n. 5, p. 426-436 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.phymed.2008.10.004 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.phymed.2008.10.004 | ||||||
| dc.identifier.epage | 436 | ||||||
| dc.identifier.hkuros | 157514 | ||||||
| dc.identifier.isi | WOS:000265952500005
Funding Information: Provision or G. lucidum (PuraLin (R))/PuraGold (R)) capsules by Dr. Kevin Chu (PuraPharm Research Corporation Ltd., Hong Kong SAR, PR China) is acknowledged. This project is financially supported by the RGC Earmarked Grants of Hong Kong SAR (Ref.: 4107/01 M and Ref.: 4166/02 M), and Direct Grants for Research (The Chinese University of Hong Kong) (Reference no.: 2401149; Project code: 2041231). | ||||||
| dc.identifier.issn | 0944-7113 2011 Impact Factor: 3.268 2011 SCImago Journal Rankings: 0.133 | ||||||
| dc.identifier.issue | 5 | ||||||
| dc.identifier.openurl | | ||||||
| dc.identifier.pmid | 19109000 | ||||||
| dc.identifier.scopus | eid_2-s2.0-64649089598 | ||||||
| dc.identifier.spage | 426 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/59561 | ||||||
| dc.identifier.volume | 16 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Urban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomed | ||||||
| dc.publisher.place | Germany | ||||||
| dc.relation.ispartof | Phytomedicine | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.subject | Ganoderma lucidum | ||||||
| dc.subject | HMG CoA reductase | ||||||
| dc.subject | PEPCK | ||||||
| dc.subject | Type 2 diabetes mellitus | ||||||
| dc.title | Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong
- University of Macau
- Hong Kong Polytechnic University
- Chinese University of Hong Kong