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Article: Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice

TitleNovel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice
Authors
KeywordsGanoderma lucidum
HMG CoA reductase
PEPCK
Type 2 diabetes mellitus
Issue Date2009
PublisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomed
Citation
Phytomedicine, 2009, v. 16 n. 5, p. 426-436 How to Cite?
AbstractIn this study, we evaluated the pharmacological effects of Ganoderma lucidum (G. lucidum) (water-extract) (0.003, 0.03 and 0.3 g/kg, 4-week oral gavage) consumption using the lean (+db/+m) and the obese/diabetic (+db/+db) mice. Different physiological parameters (plasma glucose and insulin levels, lipoproteins-cholesterol levels, phosphoenolpyruvate carboxykinase (PEPCK), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase) and isolated aorta relaxation of both species were measured and compared. G. lucidum (0.03 and 0.3 g/kg) lowered the serum glucose level in +db/+db mice after the first week of treatment whereas a reduction was observed in +db/+m mice only fed with 0.3 g/kg of G. lucidum at the fourth week. A higher hepatic PEPCK gene expression was found in +db/+db mice. G. lucidum (0.03 and 0.3 g/kg) markedly reduced the PEPCK expression in +db/+db mice whereas the expression of PEPCK was attenuated in +db/+m mice (0.3 g/kg G. lucidum). HMG CoA reductase protein expression (in both hepatic and extra-hepatic organs) and the serum insulin level were not altered by G. lucidum. These data demonstrate that G. lucidum consumption can provide beneficial effects in treating type 2 diabetes mellitus (T2DM) by lowering the serum glucose levels through the suppression of the hepatic PEPCK gene expression. © 2008 Elsevier GmbH. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59561
ISSN
2015 Impact Factor: 2.937
2015 SCImago Journal Rankings: 1.013
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong SAR4107/01 M
4166/02 M
The Chinese University of Hong Kong2401149
2041231
Funding Information:

Provision or G. lucidum (PuraLin (R))/PuraGold (R)) capsules by Dr. Kevin Chu (PuraPharm Research Corporation Ltd., Hong Kong SAR, PR China) is acknowledged. This project is financially supported by the RGC Earmarked Grants of Hong Kong SAR (Ref.: 4107/01 M and Ref.: 4166/02 M), and Direct Grants for Research (The Chinese University of Hong Kong) (Reference no.: 2401149; Project code: 2041231).

References

 

DC FieldValueLanguage
dc.contributor.authorSeto, SWen_HK
dc.contributor.authorLam, TYen_HK
dc.contributor.authorTam, HLen_HK
dc.contributor.authorAu, ALSen_HK
dc.contributor.authorChan, SWen_HK
dc.contributor.authorWu, JHen_HK
dc.contributor.authorYu, PHFen_HK
dc.contributor.authorLeung, GPHen_HK
dc.contributor.authorNgai, SMen_HK
dc.contributor.authorYeung, JHKen_HK
dc.contributor.authorLeung, PSen_HK
dc.contributor.authorLee, SMYen_HK
dc.contributor.authorKwan, YWen_HK
dc.date.accessioned2010-05-31T03:52:44Z-
dc.date.available2010-05-31T03:52:44Z-
dc.date.issued2009en_HK
dc.identifier.citationPhytomedicine, 2009, v. 16 n. 5, p. 426-436en_HK
dc.identifier.issn0944-7113en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59561-
dc.description.abstractIn this study, we evaluated the pharmacological effects of Ganoderma lucidum (G. lucidum) (water-extract) (0.003, 0.03 and 0.3 g/kg, 4-week oral gavage) consumption using the lean (+db/+m) and the obese/diabetic (+db/+db) mice. Different physiological parameters (plasma glucose and insulin levels, lipoproteins-cholesterol levels, phosphoenolpyruvate carboxykinase (PEPCK), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase) and isolated aorta relaxation of both species were measured and compared. G. lucidum (0.03 and 0.3 g/kg) lowered the serum glucose level in +db/+db mice after the first week of treatment whereas a reduction was observed in +db/+m mice only fed with 0.3 g/kg of G. lucidum at the fourth week. A higher hepatic PEPCK gene expression was found in +db/+db mice. G. lucidum (0.03 and 0.3 g/kg) markedly reduced the PEPCK expression in +db/+db mice whereas the expression of PEPCK was attenuated in +db/+m mice (0.3 g/kg G. lucidum). HMG CoA reductase protein expression (in both hepatic and extra-hepatic organs) and the serum insulin level were not altered by G. lucidum. These data demonstrate that G. lucidum consumption can provide beneficial effects in treating type 2 diabetes mellitus (T2DM) by lowering the serum glucose levels through the suppression of the hepatic PEPCK gene expression. © 2008 Elsevier GmbH. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomeden_HK
dc.relation.ispartofPhytomedicineen_HK
dc.subjectGanoderma lucidumen_HK
dc.subjectHMG CoA reductaseen_HK
dc.subjectPEPCKen_HK
dc.subjectType 2 diabetes mellitusen_HK
dc.titleNovel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0944-7113&volume=16&spage=426&epage=436&date=2009&atitle=Novel+hypoglycemic+effects+of+Ganoderma+lucidum+water-extract+in+obese/diabetic+(+db/+db)+miceen_HK
dc.identifier.emailLeung, GPH: gphleung@hkucc.hku.hken_HK
dc.identifier.authorityLeung, GPH=rp00234en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.phymed.2008.10.004en_HK
dc.identifier.pmid19109000-
dc.identifier.scopuseid_2-s2.0-64649089598en_HK
dc.identifier.hkuros157514en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-64649089598&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue5en_HK
dc.identifier.spage426en_HK
dc.identifier.epage436en_HK
dc.identifier.isiWOS:000265952500005-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridSeto, SW=9941482400en_HK
dc.identifier.scopusauthoridLam, TY=18134321000en_HK
dc.identifier.scopusauthoridTam, HL=36774787000en_HK
dc.identifier.scopusauthoridAu, ALS=7005391144en_HK
dc.identifier.scopusauthoridChan, SW=7404255670en_HK
dc.identifier.scopusauthoridWu, JH=35313190600en_HK
dc.identifier.scopusauthoridYu, PHF=13805193400en_HK
dc.identifier.scopusauthoridLeung, GPH=35963668200en_HK
dc.identifier.scopusauthoridNgai, SM=7006074219en_HK
dc.identifier.scopusauthoridYeung, JHK=7006803824en_HK
dc.identifier.scopusauthoridLeung, PS=7401748938en_HK
dc.identifier.scopusauthoridLee, SMY=35233892600en_HK
dc.identifier.scopusauthoridKwan, YW=7005662153en_HK

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