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Article: Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice
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TitleNovel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice
 
AuthorsSeto, SW4 4
Lam, TY4 4
Tam, HL3
Au, ALS4 4
Chan, SW3
Wu, JH3
Yu, PHF3
Leung, GPH1
Ngai, SM4
Yeung, JHK4 4
Leung, PS4
Lee, SMY2
Kwan, YW4 4 4
 
KeywordsGanoderma lucidum
HMG CoA reductase
PEPCK
Type 2 diabetes mellitus
 
Issue Date2009
 
PublisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomed
 
CitationPhytomedicine, 2009, v. 16 n. 5, p. 426-436 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.phymed.2008.10.004
 
AbstractIn this study, we evaluated the pharmacological effects of Ganoderma lucidum (G. lucidum) (water-extract) (0.003, 0.03 and 0.3 g/kg, 4-week oral gavage) consumption using the lean (+db/+m) and the obese/diabetic (+db/+db) mice. Different physiological parameters (plasma glucose and insulin levels, lipoproteins-cholesterol levels, phosphoenolpyruvate carboxykinase (PEPCK), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase) and isolated aorta relaxation of both species were measured and compared. G. lucidum (0.03 and 0.3 g/kg) lowered the serum glucose level in +db/+db mice after the first week of treatment whereas a reduction was observed in +db/+m mice only fed with 0.3 g/kg of G. lucidum at the fourth week. A higher hepatic PEPCK gene expression was found in +db/+db mice. G. lucidum (0.03 and 0.3 g/kg) markedly reduced the PEPCK expression in +db/+db mice whereas the expression of PEPCK was attenuated in +db/+m mice (0.3 g/kg G. lucidum). HMG CoA reductase protein expression (in both hepatic and extra-hepatic organs) and the serum insulin level were not altered by G. lucidum. These data demonstrate that G. lucidum consumption can provide beneficial effects in treating type 2 diabetes mellitus (T2DM) by lowering the serum glucose levels through the suppression of the hepatic PEPCK gene expression. © 2008 Elsevier GmbH. All rights reserved.
 
ISSN0944-7113
2012 Impact Factor: 2.972
2012 SCImago Journal Rankings: 0.952
 
DOIhttp://dx.doi.org/10.1016/j.phymed.2008.10.004
 
ISI Accession Number IDWOS:000265952500005
Funding AgencyGrant Number
Hong Kong SAR4107/01 M
4166/02 M
The Chinese University of Hong Kong2401149
2041231
Funding Information:

Provision or G. lucidum (PuraLin (R))/PuraGold (R)) capsules by Dr. Kevin Chu (PuraPharm Research Corporation Ltd., Hong Kong SAR, PR China) is acknowledged. This project is financially supported by the RGC Earmarked Grants of Hong Kong SAR (Ref.: 4107/01 M and Ref.: 4166/02 M), and Direct Grants for Research (The Chinese University of Hong Kong) (Reference no.: 2401149; Project code: 2041231).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorSeto, SW
 
dc.contributor.authorLam, TY
 
dc.contributor.authorTam, HL
 
dc.contributor.authorAu, ALS
 
dc.contributor.authorChan, SW
 
dc.contributor.authorWu, JH
 
dc.contributor.authorYu, PHF
 
dc.contributor.authorLeung, GPH
 
dc.contributor.authorNgai, SM
 
dc.contributor.authorYeung, JHK
 
dc.contributor.authorLeung, PS
 
dc.contributor.authorLee, SMY
 
dc.contributor.authorKwan, YW
 
dc.date.accessioned2010-05-31T03:52:44Z
 
dc.date.available2010-05-31T03:52:44Z
 
dc.date.issued2009
 
dc.description.abstractIn this study, we evaluated the pharmacological effects of Ganoderma lucidum (G. lucidum) (water-extract) (0.003, 0.03 and 0.3 g/kg, 4-week oral gavage) consumption using the lean (+db/+m) and the obese/diabetic (+db/+db) mice. Different physiological parameters (plasma glucose and insulin levels, lipoproteins-cholesterol levels, phosphoenolpyruvate carboxykinase (PEPCK), 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase) and isolated aorta relaxation of both species were measured and compared. G. lucidum (0.03 and 0.3 g/kg) lowered the serum glucose level in +db/+db mice after the first week of treatment whereas a reduction was observed in +db/+m mice only fed with 0.3 g/kg of G. lucidum at the fourth week. A higher hepatic PEPCK gene expression was found in +db/+db mice. G. lucidum (0.03 and 0.3 g/kg) markedly reduced the PEPCK expression in +db/+db mice whereas the expression of PEPCK was attenuated in +db/+m mice (0.3 g/kg G. lucidum). HMG CoA reductase protein expression (in both hepatic and extra-hepatic organs) and the serum insulin level were not altered by G. lucidum. These data demonstrate that G. lucidum consumption can provide beneficial effects in treating type 2 diabetes mellitus (T2DM) by lowering the serum glucose levels through the suppression of the hepatic PEPCK gene expression. © 2008 Elsevier GmbH. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationPhytomedicine, 2009, v. 16 n. 5, p. 426-436 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.phymed.2008.10.004
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.phymed.2008.10.004
 
dc.identifier.epage436
 
dc.identifier.hkuros157514
 
dc.identifier.isiWOS:000265952500005
Funding AgencyGrant Number
Hong Kong SAR4107/01 M
4166/02 M
The Chinese University of Hong Kong2401149
2041231
Funding Information:

Provision or G. lucidum (PuraLin (R))/PuraGold (R)) capsules by Dr. Kevin Chu (PuraPharm Research Corporation Ltd., Hong Kong SAR, PR China) is acknowledged. This project is financially supported by the RGC Earmarked Grants of Hong Kong SAR (Ref.: 4107/01 M and Ref.: 4166/02 M), and Direct Grants for Research (The Chinese University of Hong Kong) (Reference no.: 2401149; Project code: 2041231).

 
dc.identifier.issn0944-7113
2012 Impact Factor: 2.972
2012 SCImago Journal Rankings: 0.952
 
dc.identifier.issue5
 
dc.identifier.openurl
 
dc.identifier.pmid19109000
 
dc.identifier.scopuseid_2-s2.0-64649089598
 
dc.identifier.spage426
 
dc.identifier.urihttp://hdl.handle.net/10722/59561
 
dc.identifier.volume16
 
dc.languageeng
 
dc.publisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomed
 
dc.publisher.placeGermany
 
dc.relation.ispartofPhytomedicine
 
dc.relation.referencesReferences in Scopus
 
dc.subjectGanoderma lucidum
 
dc.subjectHMG CoA reductase
 
dc.subjectPEPCK
 
dc.subjectType 2 diabetes mellitus
 
dc.titleNovel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. University of Macau
  3. Hong Kong Polytechnic University
  4. Chinese University of Hong Kong