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Article: Vascular effects of different lipophilic components of "Danshen", a traditional Chinese medicine, in the isolated porcine coronary artery

TitleVascular effects of different lipophilic components of "Danshen", a traditional Chinese medicine, in the isolated porcine coronary artery
Authors
Issue Date2008
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/jnp
Citation
Journal Of Natural Products, 2008, v. 71 n. 11, p. 1825-1828 How to Cite?
Abstract"Danshen" has been used for the treatment of various cardiovascular diseases in the People's Republic of China for many years. Two different forms of "Danshen" exist, with the roots of Salvia miltiorrhiza being the traditional form and the roots of Salvia przewalskii being a surrogate used in the western areas of mainland China. The most abundant lipophilic diterpene quinones present in S. miltiorrhiza and S. przewalskii roots, tanshinone IIA (1) and cryptotanshinone (2), inhibited contraction of the isolated porcine coronary artery to the thromboxane A 2 analogue, U46619. Przewaquinone A (3), a lipophilic diterpene quinone present only in S. przewalskii, induced a similar but greater inhibitory action on vascular contraction than 1 and 2. This effect of 3 was endothelium-independent and reversible. The present results suggest that 3 is more potent than 1 and 2 and may contribute to a great extent to the ability of S. przewalskii roots to inhibit vascular contractions. © 2008 American Chemical Society and American Society of Pharmacognosy.
Persistent Identifierhttp://hdl.handle.net/10722/59555
ISSN
2015 Impact Factor: 3.662
2015 SCImago Journal Rankings: 1.440
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWan, AKSen_HK
dc.contributor.authorLeung, SWSen_HK
dc.contributor.authorZhu, DYen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2010-05-31T03:52:37Z-
dc.date.available2010-05-31T03:52:37Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Natural Products, 2008, v. 71 n. 11, p. 1825-1828en_HK
dc.identifier.issn0163-3864en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59555-
dc.description.abstract"Danshen" has been used for the treatment of various cardiovascular diseases in the People's Republic of China for many years. Two different forms of "Danshen" exist, with the roots of Salvia miltiorrhiza being the traditional form and the roots of Salvia przewalskii being a surrogate used in the western areas of mainland China. The most abundant lipophilic diterpene quinones present in S. miltiorrhiza and S. przewalskii roots, tanshinone IIA (1) and cryptotanshinone (2), inhibited contraction of the isolated porcine coronary artery to the thromboxane A 2 analogue, U46619. Przewaquinone A (3), a lipophilic diterpene quinone present only in S. przewalskii, induced a similar but greater inhibitory action on vascular contraction than 1 and 2. This effect of 3 was endothelium-independent and reversible. The present results suggest that 3 is more potent than 1 and 2 and may contribute to a great extent to the ability of S. przewalskii roots to inhibit vascular contractions. © 2008 American Chemical Society and American Society of Pharmacognosy.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/jnpen_HK
dc.relation.ispartofJournal of Natural Productsen_HK
dc.titleVascular effects of different lipophilic components of "Danshen", a traditional Chinese medicine, in the isolated porcine coronary arteryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0163-3864&volume=71&spage=1825&epage=1828&date=2008&atitle=Vascular+effects+of+different+lipophilic+components+of+“danshen,+a+traditional+Chinese+medicine,+in+the+isolated+porcine+coronary+arteryen_HK
dc.identifier.emailLeung, SWS: swsleung@hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SWS=rp00235en_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/np800119ken_HK
dc.identifier.pmid18855446en_HK
dc.identifier.scopuseid_2-s2.0-58149149908en_HK
dc.identifier.hkuros156231en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58149149908&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume71en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1825en_HK
dc.identifier.epage1828en_HK
dc.identifier.eissn1520-6025-
dc.identifier.isiWOS:000261335800006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWan, AKS=25931749000en_HK
dc.identifier.scopusauthoridLeung, SWS=24540419500en_HK
dc.identifier.scopusauthoridZhu, DY=7403598969en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK

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