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- Publisher Website: 10.1097/gme.0b013e3181813346
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- PMID: 19131845
- WOS: WOS:000262333100019
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Article: Vascular effects of estrone and diethylstilbestrol in porcine coronary arteries
Title | Vascular effects of estrone and diethylstilbestrol in porcine coronary arteries | ||||||
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Authors | |||||||
Keywords | Diethylstilbestrol Estrogens Estrone Vascular function | ||||||
Issue Date | 2009 | ||||||
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.menopausejournal.com | ||||||
Citation | Menopause, 2009, v. 16 n. 1, p. 104-109 How to Cite? | ||||||
Abstract | OBJECTIVE: To explore the effects of different estrogens on vascular function, we compared the vasorelaxant effects of 17β2-estradiol, 17β±-estradiol, estrone, and the synthetic estrogen diethylstilbestrol (DES) on porcine coronary arterial segments. DESIGN: Porcine coronary arterial rings were contracted with the stable thromboxane A2 analogue U46619 (3 × 10 M), and direct relaxation was examined by the addition of increasing concentrations of 17β2-estradiol, 17β±-estradiol, estrone, or DES (10 to 10 M). Modulation of agonist-induced contraction and relaxation was studied in coronary arterial rings incubated for 20 minutes with DES or estrone (10-10 M) with 17β2-estradiol (10 M) as comparison. RESULTS: Direct relaxation of arterial rings potentiated by these estrogens was recorded with a rank order potency of DES > 17β2-estradiol > estrone > 17β±-estradiol. 17β2-Estradiol potentiated relaxation responses to sodium nitroprusside and levcromakalim but not bradykinin or A23187 while reducing contractions to 5-hydroxytryptamine and U46619. DES and estrone, both at 10 M, mimicked the 17β2-estradiol-potentiated sodium nitroprusside and levcromakalim relaxation responses. Additionally, the inhibitory effects of 17β2-estradiol (10 M) on 5-hydroxytryptamine- and U46619-induced contractions were partially reproducible by DES (10 M) and estrone (10 M). CONCLUSIONS: Although DES is the most potent among the tested estrogenic compounds in eliciting relaxation, 17β2-estradiol is more effective than estrone and DES at enhancing endothelium-independent relaxation and reducing vascular contraction in porcine coronary arteries. Copyright © 2009 The North American Menopause Society. | ||||||
Persistent Identifier | http://hdl.handle.net/10722/59553 | ||||||
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.984 | ||||||
ISI Accession Number ID |
Funding Information: Funding/Support: This study was Supported in part by a Committee on Research and Conference grant and a postdoctoral fellowship (H.T.) from the University of Hong Kong. | ||||||
References |
DC Field | Value | Language |
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dc.contributor.author | Teoh, H | en_HK |
dc.contributor.author | Quan, A | en_HK |
dc.contributor.author | Leung, SWS | en_HK |
dc.contributor.author | Man, RYK | en_HK |
dc.date.accessioned | 2010-05-31T03:52:35Z | - |
dc.date.available | 2010-05-31T03:52:35Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | Menopause, 2009, v. 16 n. 1, p. 104-109 | en_HK |
dc.identifier.issn | 1072-3714 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/59553 | - |
dc.description.abstract | OBJECTIVE: To explore the effects of different estrogens on vascular function, we compared the vasorelaxant effects of 17β2-estradiol, 17β±-estradiol, estrone, and the synthetic estrogen diethylstilbestrol (DES) on porcine coronary arterial segments. DESIGN: Porcine coronary arterial rings were contracted with the stable thromboxane A2 analogue U46619 (3 × 10 M), and direct relaxation was examined by the addition of increasing concentrations of 17β2-estradiol, 17β±-estradiol, estrone, or DES (10 to 10 M). Modulation of agonist-induced contraction and relaxation was studied in coronary arterial rings incubated for 20 minutes with DES or estrone (10-10 M) with 17β2-estradiol (10 M) as comparison. RESULTS: Direct relaxation of arterial rings potentiated by these estrogens was recorded with a rank order potency of DES > 17β2-estradiol > estrone > 17β±-estradiol. 17β2-Estradiol potentiated relaxation responses to sodium nitroprusside and levcromakalim but not bradykinin or A23187 while reducing contractions to 5-hydroxytryptamine and U46619. DES and estrone, both at 10 M, mimicked the 17β2-estradiol-potentiated sodium nitroprusside and levcromakalim relaxation responses. Additionally, the inhibitory effects of 17β2-estradiol (10 M) on 5-hydroxytryptamine- and U46619-induced contractions were partially reproducible by DES (10 M) and estrone (10 M). CONCLUSIONS: Although DES is the most potent among the tested estrogenic compounds in eliciting relaxation, 17β2-estradiol is more effective than estrone and DES at enhancing endothelium-independent relaxation and reducing vascular contraction in porcine coronary arteries. Copyright © 2009 The North American Menopause Society. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.menopausejournal.com | en_HK |
dc.relation.ispartof | Menopause | en_HK |
dc.rights | Menopause . Copyright © Lippincott Williams & Wilkins. | en_HK |
dc.subject | Diethylstilbestrol | en_HK |
dc.subject | Estrogens | en_HK |
dc.subject | Estrone | en_HK |
dc.subject | Vascular function | en_HK |
dc.title | Vascular effects of estrone and diethylstilbestrol in porcine coronary arteries | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1072-3714&volume=16&spage=104&epage=109&date=2009&atitle=Vascular+effects+of+estrone+and+diethylstilbestrol+in+porcine+coronary+arteries | en_HK |
dc.identifier.email | Leung, SWS: swsleung@hku.hk | en_HK |
dc.identifier.email | Man, RYK: rykman@hkucc.hku.hk | en_HK |
dc.identifier.authority | Leung, SWS=rp00235 | en_HK |
dc.identifier.authority | Man, RYK=rp00236 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1097/gme.0b013e3181813346 | en_HK |
dc.identifier.pmid | 19131845 | - |
dc.identifier.scopus | eid_2-s2.0-64049114397 | en_HK |
dc.identifier.hkuros | 156176 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-64049114397&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 16 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 104 | en_HK |
dc.identifier.epage | 109 | en_HK |
dc.identifier.eissn | 1530-0374 | - |
dc.identifier.isi | WOS:000262333100019 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Teoh, H=7003816542 | en_HK |
dc.identifier.scopusauthorid | Quan, A=7006871453 | en_HK |
dc.identifier.scopusauthorid | Leung, SWS=24540419500 | en_HK |
dc.identifier.scopusauthorid | Man, RYK=7004986435 | en_HK |
dc.identifier.issnl | 1072-3714 | - |