Article: A novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome

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TitleA novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome
AuthorsSze, SCW1
Tong, Y1
Zhang, YB1
Zhang, ZJ1
Lau, ASL1
Wong, HK1
Tsang, KW1
Ng, TB1
KeywordsAntioxidant
Chinese medicine
Endocrine function
Erxian Decoction
Menopause
Issue Date2009
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharm
CitationJournal Of Ethnopharmacology, 2009, v. 123 n. 1, p. 27-33 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jep.2009.02.034
AbstractEthnopharmacological relevance: Many clinical and experimental reports demonstrated that Erxian Decoction (EXD) was effective in relieving menopausal syndrome. Aim of the study: The mechanisms of action of EXD were explored on the endocrine and antioxidant regimen. Materials and methods: Menopause causes a decline in both endocrine function and activities of antioxidant enzymes. In this study, 12-month-old female Sprague-Dawley-rats (SD-rats) with a low serum estradiol level were employed. Their endocrine functions after treatment with EXD were assessed by the determination of their serum estradiol level and ovarian mRNA levels of aromatase, which is a key enzyme for biosynthesis of estradiol. Meanwhile, superoxide dismutase-1 (SOD), catalase (CAT) and glutathione peroxidase (GPx-1) in the liver were also determined to assess the effect of EXD on the antioxidant regimen. Results: Results revealed a significant elevation in serum estradiol level and the mRNA level of ovarian aromatase and liver CAT in the EXD-treated menopausal rat model. Conclusions: The results obtained from mRNA and estradiol level of the present investigation revealed that the EXD relieves the menopausal syndrome involved an increase of endocrine and antioxidant function through, at least, the activation of aromatase and CAT detoxifying pathways. © 2009 Elsevier Ireland Ltd. All rights reserved.
ISSN0378-8741
2011 Impact Factor: 3.014
2011 SCImago Journal Rankings: 0.114
DOIhttp://dx.doi.org/10.1016/j.jep.2009.02.034
ReferencesReferences in Scopus
GrantsMechanistics Study on the Molecular Actions of a Modern Chinese Medicine Decoction (GFP) in Estrogen Secretion in Rat Granulose Cell via Aromatase Activation in vitro.
Bioactive Components of Erxian Decoction as a Potential Drug Candidate for Peri-menopausal Syndrome
DC Field
Value
dc.contributor.authorSze, SCW
dc.contributor.authorTong, Y
dc.contributor.authorZhang, YB
dc.contributor.authorZhang, ZJ
dc.contributor.authorLau, ASL
dc.contributor.authorWong, HK
dc.contributor.authorTsang, KW
dc.contributor.authorNg, TB
dc.date.accessioned2010-05-31T03:51:57Z
dc.date.available2010-05-31T03:51:57Z
dc.date.issued2009
dc.description.abstractEthnopharmacological relevance: Many clinical and experimental reports demonstrated that Erxian Decoction (EXD) was effective in relieving menopausal syndrome. Aim of the study: The mechanisms of action of EXD were explored on the endocrine and antioxidant regimen. Materials and methods: Menopause causes a decline in both endocrine function and activities of antioxidant enzymes. In this study, 12-month-old female Sprague-Dawley-rats (SD-rats) with a low serum estradiol level were employed. Their endocrine functions after treatment with EXD were assessed by the determination of their serum estradiol level and ovarian mRNA levels of aromatase, which is a key enzyme for biosynthesis of estradiol. Meanwhile, superoxide dismutase-1 (SOD), catalase (CAT) and glutathione peroxidase (GPx-1) in the liver were also determined to assess the effect of EXD on the antioxidant regimen. Results: Results revealed a significant elevation in serum estradiol level and the mRNA level of ovarian aromatase and liver CAT in the EXD-treated menopausal rat model. Conclusions: The results obtained from mRNA and estradiol level of the present investigation revealed that the EXD relieves the menopausal syndrome involved an increase of endocrine and antioxidant function through, at least, the activation of aromatase and CAT detoxifying pathways. © 2009 Elsevier Ireland Ltd. All rights reserved.
dc.description.grantMechanistics Study on the Molecular Actions of a Modern Chinese Medicine Decoction (GFP) in Estrogen Secretion in Rat Granulose Cell via Aromatase Activation in vitro.
dc.description.grantBioactive Components of Erxian Decoction as a Potential Drug Candidate for Peri-menopausal Syndrome
dc.description.grantcode82569
dc.description.grantcode98291
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Ethnopharmacology, 2009, v. 123 n. 1, p. 27-33 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jep.2009.02.034
dc.identifier.doihttp://dx.doi.org/10.1016/j.jep.2009.02.034
dc.identifier.epage33
dc.identifier.hkuros159175
dc.identifier.isiWOS:000266124600005
Funding AgencyGrant Number
Small Project Funding200607176131
Seed Funding Programme for Applied Research200802160025
University of Hong Kong and Liu Hao Tsing Foundation Ltd.
Funding Information:

This research was supported in part by a grant from Small Project Funding (no. 200607176131), Seed Funding Programme for Applied Research (no. 200802160025), the University of Hong Kong and Liu Hao Tsing Foundation Ltd. We also thank Ms. Cindy Lee for expert technical assistance.

dc.identifier.issn0378-8741
2011 Impact Factor: 3.014
2011 SCImago Journal Rankings: 0.114
dc.identifier.issue1
dc.identifier.openurl
dc.identifier.pmid19429335
dc.identifier.scopuseid_2-s2.0-64449086729
dc.identifier.spage27
dc.identifier.urihttp://hdl.handle.net/10722/59523
dc.identifier.volume123
dc.languageeng
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharm
dc.publisher.placeIreland
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.referencesReferences in Scopus
dc.rightsJournal of Ethnopharmacology. Copyright © Elsevier Ireland Ltd.
dc.subjectAntioxidant
dc.subjectChinese medicine
dc.subjectEndocrine function
dc.subjectErxian Decoction
dc.subjectMenopause
dc.titleA novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine