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Article: A novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome
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TitleA novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome
 
AuthorsSze, SCW1
Tong, Y1
Zhang, YB1
Zhang, ZJ1
Lau, ASL1
Wong, HK1
Tsang, KW1
Ng, TB2
 
KeywordsAntioxidant
Chinese medicine
Endocrine function
Erxian Decoction
Menopause
 
Issue Date2009
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharm
 
CitationJournal Of Ethnopharmacology, 2009, v. 123 n. 1, p. 27-33 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jep.2009.02.034
 
AbstractEthnopharmacological relevance: Many clinical and experimental reports demonstrated that Erxian Decoction (EXD) was effective in relieving menopausal syndrome. Aim of the study: The mechanisms of action of EXD were explored on the endocrine and antioxidant regimen. Materials and methods: Menopause causes a decline in both endocrine function and activities of antioxidant enzymes. In this study, 12-month-old female Sprague-Dawley-rats (SD-rats) with a low serum estradiol level were employed. Their endocrine functions after treatment with EXD were assessed by the determination of their serum estradiol level and ovarian mRNA levels of aromatase, which is a key enzyme for biosynthesis of estradiol. Meanwhile, superoxide dismutase-1 (SOD), catalase (CAT) and glutathione peroxidase (GPx-1) in the liver were also determined to assess the effect of EXD on the antioxidant regimen. Results: Results revealed a significant elevation in serum estradiol level and the mRNA level of ovarian aromatase and liver CAT in the EXD-treated menopausal rat model. Conclusions: The results obtained from mRNA and estradiol level of the present investigation revealed that the EXD relieves the menopausal syndrome involved an increase of endocrine and antioxidant function through, at least, the activation of aromatase and CAT detoxifying pathways. © 2009 Elsevier Ireland Ltd. All rights reserved.
 
ISSN0378-8741
2012 Impact Factor: 2.755
2012 SCImago Journal Rankings: 0.994
 
DOIhttp://dx.doi.org/10.1016/j.jep.2009.02.034
 
ISI Accession Number IDWOS:000266124600005
Funding AgencyGrant Number
Small Project Funding200607176131
Seed Funding Programme for Applied Research200802160025
University of Hong Kong and Liu Hao Tsing Foundation Ltd.
Funding Information:

This research was supported in part by a grant from Small Project Funding (no. 200607176131), Seed Funding Programme for Applied Research (no. 200802160025), the University of Hong Kong and Liu Hao Tsing Foundation Ltd. We also thank Ms. Cindy Lee for expert technical assistance.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorSze, SCW
 
dc.contributor.authorTong, Y
 
dc.contributor.authorZhang, YB
 
dc.contributor.authorZhang, ZJ
 
dc.contributor.authorLau, ASL
 
dc.contributor.authorWong, HK
 
dc.contributor.authorTsang, KW
 
dc.contributor.authorNg, TB
 
dc.date.accessioned2010-05-31T03:51:57Z
 
dc.date.available2010-05-31T03:51:57Z
 
dc.date.issued2009
 
dc.description.abstractEthnopharmacological relevance: Many clinical and experimental reports demonstrated that Erxian Decoction (EXD) was effective in relieving menopausal syndrome. Aim of the study: The mechanisms of action of EXD were explored on the endocrine and antioxidant regimen. Materials and methods: Menopause causes a decline in both endocrine function and activities of antioxidant enzymes. In this study, 12-month-old female Sprague-Dawley-rats (SD-rats) with a low serum estradiol level were employed. Their endocrine functions after treatment with EXD were assessed by the determination of their serum estradiol level and ovarian mRNA levels of aromatase, which is a key enzyme for biosynthesis of estradiol. Meanwhile, superoxide dismutase-1 (SOD), catalase (CAT) and glutathione peroxidase (GPx-1) in the liver were also determined to assess the effect of EXD on the antioxidant regimen. Results: Results revealed a significant elevation in serum estradiol level and the mRNA level of ovarian aromatase and liver CAT in the EXD-treated menopausal rat model. Conclusions: The results obtained from mRNA and estradiol level of the present investigation revealed that the EXD relieves the menopausal syndrome involved an increase of endocrine and antioxidant function through, at least, the activation of aromatase and CAT detoxifying pathways. © 2009 Elsevier Ireland Ltd. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Ethnopharmacology, 2009, v. 123 n. 1, p. 27-33 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jep.2009.02.034
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.jep.2009.02.034
 
dc.identifier.eissn1872-7573
 
dc.identifier.epage33
 
dc.identifier.hkuros159175
 
dc.identifier.isiWOS:000266124600005
Funding AgencyGrant Number
Small Project Funding200607176131
Seed Funding Programme for Applied Research200802160025
University of Hong Kong and Liu Hao Tsing Foundation Ltd.
Funding Information:

This research was supported in part by a grant from Small Project Funding (no. 200607176131), Seed Funding Programme for Applied Research (no. 200802160025), the University of Hong Kong and Liu Hao Tsing Foundation Ltd. We also thank Ms. Cindy Lee for expert technical assistance.

 
dc.identifier.issn0378-8741
2012 Impact Factor: 2.755
2012 SCImago Journal Rankings: 0.994
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid19429335
 
dc.identifier.scopuseid_2-s2.0-64449086729
 
dc.identifier.spage27
 
dc.identifier.urihttp://hdl.handle.net/10722/59523
 
dc.identifier.volume123
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharm
 
dc.publisher.placeIreland
 
dc.relation.ispartofJournal of Ethnopharmacology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Ethnopharmacology. Copyright © Elsevier Ireland Ltd.
 
dc.subjectAntioxidant
 
dc.subjectChinese medicine
 
dc.subjectEndocrine function
 
dc.subjectErxian Decoction
 
dc.subjectMenopause
 
dc.titleA novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Chinese University of Hong Kong