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Article: A novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome

TitleA novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome
Authors
KeywordsAntioxidant
Chinese medicine
Endocrine function
Erxian Decoction
Menopause
Issue Date2009
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharm
Citation
Journal Of Ethnopharmacology, 2009, v. 123 n. 1, p. 27-33 How to Cite?
AbstractEthnopharmacological relevance: Many clinical and experimental reports demonstrated that Erxian Decoction (EXD) was effective in relieving menopausal syndrome. Aim of the study: The mechanisms of action of EXD were explored on the endocrine and antioxidant regimen. Materials and methods: Menopause causes a decline in both endocrine function and activities of antioxidant enzymes. In this study, 12-month-old female Sprague-Dawley-rats (SD-rats) with a low serum estradiol level were employed. Their endocrine functions after treatment with EXD were assessed by the determination of their serum estradiol level and ovarian mRNA levels of aromatase, which is a key enzyme for biosynthesis of estradiol. Meanwhile, superoxide dismutase-1 (SOD), catalase (CAT) and glutathione peroxidase (GPx-1) in the liver were also determined to assess the effect of EXD on the antioxidant regimen. Results: Results revealed a significant elevation in serum estradiol level and the mRNA level of ovarian aromatase and liver CAT in the EXD-treated menopausal rat model. Conclusions: The results obtained from mRNA and estradiol level of the present investigation revealed that the EXD relieves the menopausal syndrome involved an increase of endocrine and antioxidant function through, at least, the activation of aromatase and CAT detoxifying pathways. © 2009 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59523
ISSN
2014 Impact Factor: 2.998
2014 SCImago Journal Rankings: 1.069
ISI Accession Number ID
Funding AgencyGrant Number
Small Project Funding200607176131
Seed Funding Programme for Applied Research200802160025
University of Hong Kong and Liu Hao Tsing Foundation Ltd.
Funding Information:

This research was supported in part by a grant from Small Project Funding (no. 200607176131), Seed Funding Programme for Applied Research (no. 200802160025), the University of Hong Kong and Liu Hao Tsing Foundation Ltd. We also thank Ms. Cindy Lee for expert technical assistance.

References

 

DC FieldValueLanguage
dc.contributor.authorSze, SCWen_HK
dc.contributor.authorTong, Yen_HK
dc.contributor.authorZhang, YBen_HK
dc.contributor.authorZhang, ZJen_HK
dc.contributor.authorLau, ASLen_HK
dc.contributor.authorWong, HKen_HK
dc.contributor.authorTsang, KWen_HK
dc.contributor.authorNg, TBen_HK
dc.date.accessioned2010-05-31T03:51:57Z-
dc.date.available2010-05-31T03:51:57Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Ethnopharmacology, 2009, v. 123 n. 1, p. 27-33en_HK
dc.identifier.issn0378-8741en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59523-
dc.description.abstractEthnopharmacological relevance: Many clinical and experimental reports demonstrated that Erxian Decoction (EXD) was effective in relieving menopausal syndrome. Aim of the study: The mechanisms of action of EXD were explored on the endocrine and antioxidant regimen. Materials and methods: Menopause causes a decline in both endocrine function and activities of antioxidant enzymes. In this study, 12-month-old female Sprague-Dawley-rats (SD-rats) with a low serum estradiol level were employed. Their endocrine functions after treatment with EXD were assessed by the determination of their serum estradiol level and ovarian mRNA levels of aromatase, which is a key enzyme for biosynthesis of estradiol. Meanwhile, superoxide dismutase-1 (SOD), catalase (CAT) and glutathione peroxidase (GPx-1) in the liver were also determined to assess the effect of EXD on the antioxidant regimen. Results: Results revealed a significant elevation in serum estradiol level and the mRNA level of ovarian aromatase and liver CAT in the EXD-treated menopausal rat model. Conclusions: The results obtained from mRNA and estradiol level of the present investigation revealed that the EXD relieves the menopausal syndrome involved an increase of endocrine and antioxidant function through, at least, the activation of aromatase and CAT detoxifying pathways. © 2009 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharmen_HK
dc.relation.ispartofJournal of Ethnopharmacologyen_HK
dc.rightsJournal of Ethnopharmacology. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectAntioxidanten_HK
dc.subjectChinese medicineen_HK
dc.subjectEndocrine functionen_HK
dc.subjectErxian Decoctionen_HK
dc.subjectMenopauseen_HK
dc.titleA novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0378-8741&volume=123&spage=27&epage=33&date=2009&atitle=A+novel+mechanism:+Erxian+decoction,+a+Chinese+medicine+formula,+for+relieving+menopausal+syndromeen_HK
dc.identifier.emailSze, SCW: stephens@hku.hken_HK
dc.identifier.emailTong, Y: tongyao@hku.hken_HK
dc.identifier.emailZhang, YB: ybzhang@hku.hken_HK
dc.identifier.authoritySze, SCW=rp00514en_HK
dc.identifier.authorityTong, Y=rp00509en_HK
dc.identifier.authorityZhang, YB=rp01410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jep.2009.02.034en_HK
dc.identifier.pmid19429335en_HK
dc.identifier.scopuseid_2-s2.0-64449086729en_HK
dc.identifier.hkuros159175en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-64449086729&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume123en_HK
dc.identifier.issue1en_HK
dc.identifier.spage27en_HK
dc.identifier.epage33en_HK
dc.identifier.eissn1872-7573-
dc.identifier.isiWOS:000266124600005-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridSze, SCW=23482617000en_HK
dc.identifier.scopusauthoridTong, Y=9045384000en_HK
dc.identifier.scopusauthoridZhang, YB=23483121900en_HK
dc.identifier.scopusauthoridZhang, ZJ=38163087300en_HK
dc.identifier.scopusauthoridLau, ASL=26030476700en_HK
dc.identifier.scopusauthoridWong, HK=36920239700en_HK
dc.identifier.scopusauthoridTsang, KW=47861536800en_HK
dc.identifier.scopusauthoridNg, TB=35311803300en_HK

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