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Article: Differences in Bcl-2 expression by T-cell subsets alter their balance after in vivo irradiation to favor CD4+Bcl-2hi NKT cells

TitleDifferences in Bcl-2 expression by T-cell subsets alter their balance after in vivo irradiation to favor CD4+Bcl-2hi NKT cells
Authors
KeywordsGraft vs Host Disease - immunology - metabolism
Interleukin-4 - immunology - metabolism
Natural Killer T-Cells - immunology - metabolism - radiation effects
Proto-Oncogene Proteins c-bcl-2 - immunology - metabolism
T-Lymphocyte Subsets - immunology - metabolism - radiation effects
Issue Date2009
PublisherWiley - VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.eji.de
Citation
European Journal of Immunology, 2009, v. 39 n. 3, p. 763-775 How to Cite?
AbstractAlthough it is well known that in vivo radiation depletes immune cells via the Bcl-2 apoptotic pathway, a more nuanced analysis of the changes in the balance of immune-cell subsets is needed to understand the impact of radiation on immune function. We show the balance of T-cell subsets changes after increasing single doses of total body irradiation (TBI) or after fractionated irradiation of the lymphoid tissues (TLI) of mice due to differences in radioresistance and Bcl-2 expression of the NKT-cell and non-NKT subsets to favor CD4(+)Bcl-2(hi) NKT cells. Reduction of the Bcl-2(lo) mature T-cell subsets was at least 100-fold greater than that of the Bcl-2(hi) subsets. CD4(+) NKT cells upregulated Bcl-2 after TBI and TLI and developed a Th2 bias after TLI, whereas non-NKT cells failed to do so. Our previous studies showed TLI protects against graft versus host disease in wild-type, but not in NKT-cell-deficient mice. The present study shows that NKT cells have a protective function even after TBI, and these cells are tenfold more abundant after an equal dose of TLI. In conclusion, differential expression of Bcl-2 contributes to the changes in T-cell subsets and immune function after irradiation.
Persistent Identifierhttp://hdl.handle.net/10722/59515
ISSN
2015 Impact Factor: 4.179
2015 SCImago Journal Rankings: 2.568
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYao, Zen_HK
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorJones, Jen_HK
dc.contributor.authorStrober, S-
dc.date.accessioned2010-05-31T03:51:48Z-
dc.date.available2010-05-31T03:51:48Z-
dc.date.issued2009en_HK
dc.identifier.citationEuropean Journal of Immunology, 2009, v. 39 n. 3, p. 763-775en_HK
dc.identifier.issn0014-2980en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59515-
dc.description.abstractAlthough it is well known that in vivo radiation depletes immune cells via the Bcl-2 apoptotic pathway, a more nuanced analysis of the changes in the balance of immune-cell subsets is needed to understand the impact of radiation on immune function. We show the balance of T-cell subsets changes after increasing single doses of total body irradiation (TBI) or after fractionated irradiation of the lymphoid tissues (TLI) of mice due to differences in radioresistance and Bcl-2 expression of the NKT-cell and non-NKT subsets to favor CD4(+)Bcl-2(hi) NKT cells. Reduction of the Bcl-2(lo) mature T-cell subsets was at least 100-fold greater than that of the Bcl-2(hi) subsets. CD4(+) NKT cells upregulated Bcl-2 after TBI and TLI and developed a Th2 bias after TLI, whereas non-NKT cells failed to do so. Our previous studies showed TLI protects against graft versus host disease in wild-type, but not in NKT-cell-deficient mice. The present study shows that NKT cells have a protective function even after TBI, and these cells are tenfold more abundant after an equal dose of TLI. In conclusion, differential expression of Bcl-2 contributes to the changes in T-cell subsets and immune function after irradiation.-
dc.languageengen_HK
dc.publisherWiley - VCH Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.eji.deen_HK
dc.relation.ispartofEuropean Journal of Immunologyen_HK
dc.subjectGraft vs Host Disease - immunology - metabolism-
dc.subjectInterleukin-4 - immunology - metabolism-
dc.subjectNatural Killer T-Cells - immunology - metabolism - radiation effects-
dc.subjectProto-Oncogene Proteins c-bcl-2 - immunology - metabolism-
dc.subjectT-Lymphocyte Subsets - immunology - metabolism - radiation effects-
dc.titleDifferences in Bcl-2 expression by T-cell subsets alter their balance after in vivo irradiation to favor CD4+Bcl-2hi NKT cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-2980&volume=39&spage=763&epage=775&date=2009&atitle=Differences+in+Bcl-2+expression+by+T-cell+subsets+alter+their+balance+after+in+vivo+irradiation+to+favor+CD4+Bcl-2hi+NKT+cells. .en_HK
dc.identifier.emailLiu, Y: yinpingl@hku.hken_HK
dc.identifier.authorityLiu, Y=rp00269en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/eji.200838657-
dc.identifier.pmid19197937-
dc.identifier.pmcidPMC2758339-
dc.identifier.hkuros163400en_HK
dc.identifier.volume39-
dc.identifier.issue3-
dc.identifier.spage763-
dc.identifier.epage775-
dc.identifier.isiWOS:000264683500025-
dc.publisher.placeGermany-

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