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Article: An herbal decoction of Radix astragali and Radix angelicae sinensis promotes hematopoiesis and thrombopoiesis

TitleAn herbal decoction of Radix astragali and Radix angelicae sinensis promotes hematopoiesis and thrombopoiesis
Authors
KeywordsApoptosis
Danggui Buxue Tang (DBT)
Hematopoiesis
Megakaryocytopoiesis
Radix angelicae sinensis
Radix astragali
Thrombopoiesis
Thrombopoietin
Issue Date2009
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharm
Citation
Journal Of Ethnopharmacology, 2009, v. 124 n. 1, p. 87-97 How to Cite?
AbstractEthnopharmacological relevance: A decoction containing Radix angelicae sinensis and Radix astragali (Danggui Buxue Tang, DBT) has been used to raise the "Qi" and nourish the "Blood". However, its effects on haematopoiesis and particularly thrombopoiesis have not been studied. Aims: This study aims to examine the effects of DBT on hematopoiesis and thrombopoiesis. Materials and methods: A myelosuppression mouse model was treated with DBT (10 mg/kg/day). Peripheral blood cells from DBT and thrombopoietin-treated samples were counted on days 0, 7, 14 and 21. Then CFU assays were used to determine the effects of DBT on the megakaryocytic progenitor cells and other lineages. Last, analyses of annexin V, caspase-3, and mitochondrial membrane potential were conducted in megakaryocytic cell line M-07e. Results: Morphological examination showed that DBT treatment significantly increased the recovery of the megakaryocytic series. DBT significantly enhanced the platelet recovery and CFU-MK formation in vivo. DBT significantly promoted CFU-MK and CFU-F formation. Last, we observed the antiapoptotic effects of DBT on M-07e cells. Conclusion: DBT might promote haematopoiesis and thrombopoiesis in the mouse model through (i) directly promoting the growth of megakaryocytes; (ii) indirectly promoting the growth of bone marrow stromal cells; (iii) inhibiting apoptosis of megakaryocytes. © 2009 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59492
ISSN
2015 Impact Factor: 3.055
2015 SCImago Journal Rankings: 1.156
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, Men_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorDeng, Ren_HK
dc.contributor.authorNg, MHen_HK
dc.contributor.authorCheng, SWen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorYe, JYen_HK
dc.contributor.authorWang, Len_HK
dc.contributor.authorLiu, Cen_HK
dc.date.accessioned2010-05-31T03:51:21Z-
dc.date.available2010-05-31T03:51:21Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Ethnopharmacology, 2009, v. 124 n. 1, p. 87-97en_HK
dc.identifier.issn0378-8741en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59492-
dc.description.abstractEthnopharmacological relevance: A decoction containing Radix angelicae sinensis and Radix astragali (Danggui Buxue Tang, DBT) has been used to raise the "Qi" and nourish the "Blood". However, its effects on haematopoiesis and particularly thrombopoiesis have not been studied. Aims: This study aims to examine the effects of DBT on hematopoiesis and thrombopoiesis. Materials and methods: A myelosuppression mouse model was treated with DBT (10 mg/kg/day). Peripheral blood cells from DBT and thrombopoietin-treated samples were counted on days 0, 7, 14 and 21. Then CFU assays were used to determine the effects of DBT on the megakaryocytic progenitor cells and other lineages. Last, analyses of annexin V, caspase-3, and mitochondrial membrane potential were conducted in megakaryocytic cell line M-07e. Results: Morphological examination showed that DBT treatment significantly increased the recovery of the megakaryocytic series. DBT significantly enhanced the platelet recovery and CFU-MK formation in vivo. DBT significantly promoted CFU-MK and CFU-F formation. Last, we observed the antiapoptotic effects of DBT on M-07e cells. Conclusion: DBT might promote haematopoiesis and thrombopoiesis in the mouse model through (i) directly promoting the growth of megakaryocytes; (ii) indirectly promoting the growth of bone marrow stromal cells; (iii) inhibiting apoptosis of megakaryocytes. © 2009 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharmen_HK
dc.relation.ispartofJournal of Ethnopharmacologyen_HK
dc.rightsJournal of Ethnopharmacology. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectApoptosisen_HK
dc.subjectDanggui Buxue Tang (DBT)en_HK
dc.subjectHematopoiesisen_HK
dc.subjectMegakaryocytopoiesisen_HK
dc.subjectRadix angelicae sinensisen_HK
dc.subjectRadix astragalien_HK
dc.subjectThrombopoiesisen_HK
dc.subjectThrombopoietinen_HK
dc.titleAn herbal decoction of Radix astragali and Radix angelicae sinensis promotes hematopoiesis and thrombopoiesisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0378-8741&volume=124&spage=87&epage=97&date=2009&atitle=An+herbal+decoction+of+Radix+astragali+and+Radix+angelicae+sinensis+promotes+hematopoiesis+and+thrombopoiesisen_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jep.2009.04.007en_HK
dc.identifier.pmid19443149-
dc.identifier.scopuseid_2-s2.0-67349154950en_HK
dc.identifier.hkuros157642en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349154950&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume124en_HK
dc.identifier.issue1en_HK
dc.identifier.spage87en_HK
dc.identifier.epage97en_HK
dc.identifier.isiWOS:000268201200010-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridYang, M=7404927250en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridDeng, R=35209695100en_HK
dc.identifier.scopusauthoridNg, MH=35292609300en_HK
dc.identifier.scopusauthoridCheng, SW=7404685666en_HK
dc.identifier.scopusauthoridLau, CP=24172781500en_HK
dc.identifier.scopusauthoridYe, JY=23669624100en_HK
dc.identifier.scopusauthoridWang, L=35212114400en_HK
dc.identifier.scopusauthoridLiu, C=36063391100en_HK

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