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Article: OIC-A006 promotes osteogenesis in vitro and in vivo

TitleOIC-A006 promotes osteogenesis in vitro and in vivo
Authors
Issue Date2008
PublisherGovi Verlag Pharmazeutischer Verlag GmbH. The Journal's web site is located at http://www.govi.de/pharmazie.htm
Citation
Pharmazie, 2008, v. 63 n. 10, p. 751-756 How to Cite?
AbstractBone morphogenesis proteins (BMPs) are one of the potent bone-forming factors. However, the safety, utility, and cost effectiveness of BMPs must be considered. Nowadays, there has been substantial interest in developing a chemical compound that safely promotes bone formation and facilitates fracture repair. Based on previous research with high throughout screening assay, we found one potent osteogenic inductive compound, named as OIC-A006 (Osteogenic inducible compound-active 006), which is classified in the amine family. In this study, we aimed to investigate the inducing effects of OIC-A006 on osteogenesis by bone marrow stem cells (BMSCs) in vitro and in vivo. We demonstrated that OIC-A006, at different concentrations, especially at optimal concentration of 6.25 μM, could stimulate BMSCs to express alkaline phosphatase (ALP), core-binding factor a1 (Cbfa1), osteopontin (OPN) and osteocalcin (OC), and to form calcified nodules in vitro. Under the bone tissue culture conditions, OIC-A006 also stimulated new bone formation of murine calvarial and metatarsal bone, indicating that OIC-A006 may exert positive effects on osteogenesis. Furthermore, to elucidate the in vivo osteogenic potential of OIC-A006, we used a rabbit skull defect model treated with sustained release microcapsules (OIC-A006/PLGA-MC) injected s.c. adjacent to the defect. These results revealed, for the first time, that OIC-A006 has the potential to promote osteogenesis in vitro and in vivo. This new compound may provide a new alterative agent for growth factors to promote bone healing and bone regeneration.
Persistent Identifierhttp://hdl.handle.net/10722/59490
ISSN
2014 Impact Factor: 1.052
2014 SCImago Journal Rankings: 0.392
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCai, Men_HK
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorShao, Jen_HK
dc.contributor.authorQi, Jen_HK
dc.contributor.authorWang, Jen_HK
dc.contributor.authorZhu, Yen_HK
dc.contributor.authorZhou, Qen_HK
dc.contributor.authorWang, Jen_HK
dc.contributor.authorZhao, Qen_HK
dc.contributor.authorLi, Gen_HK
dc.contributor.authorLiang, Jen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorDeng, Len_HK
dc.date.accessioned2010-05-31T03:51:14Z-
dc.date.available2010-05-31T03:51:14Z-
dc.date.issued2008en_HK
dc.identifier.citationPharmazie, 2008, v. 63 n. 10, p. 751-756en_HK
dc.identifier.issn0031-7144en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59490-
dc.description.abstractBone morphogenesis proteins (BMPs) are one of the potent bone-forming factors. However, the safety, utility, and cost effectiveness of BMPs must be considered. Nowadays, there has been substantial interest in developing a chemical compound that safely promotes bone formation and facilitates fracture repair. Based on previous research with high throughout screening assay, we found one potent osteogenic inductive compound, named as OIC-A006 (Osteogenic inducible compound-active 006), which is classified in the amine family. In this study, we aimed to investigate the inducing effects of OIC-A006 on osteogenesis by bone marrow stem cells (BMSCs) in vitro and in vivo. We demonstrated that OIC-A006, at different concentrations, especially at optimal concentration of 6.25 μM, could stimulate BMSCs to express alkaline phosphatase (ALP), core-binding factor a1 (Cbfa1), osteopontin (OPN) and osteocalcin (OC), and to form calcified nodules in vitro. Under the bone tissue culture conditions, OIC-A006 also stimulated new bone formation of murine calvarial and metatarsal bone, indicating that OIC-A006 may exert positive effects on osteogenesis. Furthermore, to elucidate the in vivo osteogenic potential of OIC-A006, we used a rabbit skull defect model treated with sustained release microcapsules (OIC-A006/PLGA-MC) injected s.c. adjacent to the defect. These results revealed, for the first time, that OIC-A006 has the potential to promote osteogenesis in vitro and in vivo. This new compound may provide a new alterative agent for growth factors to promote bone healing and bone regeneration.en_HK
dc.languageengen_HK
dc.publisherGovi Verlag Pharmazeutischer Verlag GmbH. The Journal's web site is located at http://www.govi.de/pharmazie.htmen_HK
dc.relation.ispartofPharmazieen_HK
dc.titleOIC-A006 promotes osteogenesis in vitro and in vivoen_HK
dc.typeArticleen_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1691/ph.2008.8559en_HK
dc.identifier.pmid18972839-
dc.identifier.scopuseid_2-s2.0-54149114730en_HK
dc.identifier.hkuros166630en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-54149114730&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume63en_HK
dc.identifier.issue10en_HK
dc.identifier.spage751en_HK
dc.identifier.epage756en_HK
dc.identifier.isiWOS:000260021800011-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridCai, M=37004403300en_HK
dc.identifier.scopusauthoridLiu, X=52864244100en_HK
dc.identifier.scopusauthoridShao, J=7201362155en_HK
dc.identifier.scopusauthoridQi, J=54886036300en_HK
dc.identifier.scopusauthoridWang, J=8716933500en_HK
dc.identifier.scopusauthoridZhu, Y=52865128800en_HK
dc.identifier.scopusauthoridZhou, Q=7402700408en_HK
dc.identifier.scopusauthoridWang, J=52864960900en_HK
dc.identifier.scopusauthoridZhao, Q=54885696700en_HK
dc.identifier.scopusauthoridLi, G=35098902300en_HK
dc.identifier.scopusauthoridLiang, J=52864296000en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridDeng, L=7202007494en_HK

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