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Article: Localizing P300 generators in high-density event-related potential with fMRI

TitleLocalizing P300 generators in high-density event-related potential with fMRI
Authors
KeywordsEEG
Event related potential
FMRI
Hemodynamic response
Landolt ring task
Issue Date2009
PublisherMedical Science International Publishing. The Journal's web site is located at http://www.medscimonit.com
Citation
Medical Science Monitor, 2009, v. 15 n. 3, p. MT47-MT53 How to Cite?
AbstractTo assess the effects of stimulus context on the P300 component, an eight-orientation Landolt ring task was introduced. As the stimulus context of this task differs from the traditional two-stimulus oddball paradigm, the purpose here was to apply EEG/fMRI integration to investigate the localization and activities of the P300 generators involved with this task. Ten healthy subjects performed the visual P300 task while fMRI and 64-channel ERP data were acquired. The voltage topographical maps of the P300 component were calculated and analyzed for the main activation foci. Furthermore, constraints from fMRI were used to identify the source activities of visual P300 ERP. Analysis of the hemodynamic response to the visual target stimuli revealed a distributed network of neural sources in the bilateral parietal lobules, middle and inferior frontal gyrus, precentral and postcentral cortex, and anterior cingulate gyrus. The analysis particularly showed preponderant activations of the bilateral superior parietal lobules. In this target detection design, two distinct P300 peaks were observed in the dipole waveforms, the bilateral prefrontal and the right inferior parietal dipole waveforms displayed the higher peak at short latency, while the four parietal, the anterior cingulate, and the temporal dipole waveforms had the higher peak at long latency. Compared with the classical oddball paradigm, the amplitude decreased in this study, which might be related to its particular stimulus context. The source technique was utilized to yield a realistic 11-dipole model and distinguish the anatomical generators of early and late components of the P300 response. © Med Sci Monit, 2009.
Persistent Identifierhttp://hdl.handle.net/10722/59483
ISSN
2012 Impact Factor: 1.358
2015 SCImago Journal Rankings: 0.512
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Yen_HK
dc.contributor.authorLiQun Wangen_HK
dc.contributor.authorHu, Yen_HK
dc.date.accessioned2010-05-31T03:51:07Z-
dc.date.available2010-05-31T03:51:07Z-
dc.date.issued2009en_HK
dc.identifier.citationMedical Science Monitor, 2009, v. 15 n. 3, p. MT47-MT53en_HK
dc.identifier.issn1234-1010en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59483-
dc.description.abstractTo assess the effects of stimulus context on the P300 component, an eight-orientation Landolt ring task was introduced. As the stimulus context of this task differs from the traditional two-stimulus oddball paradigm, the purpose here was to apply EEG/fMRI integration to investigate the localization and activities of the P300 generators involved with this task. Ten healthy subjects performed the visual P300 task while fMRI and 64-channel ERP data were acquired. The voltage topographical maps of the P300 component were calculated and analyzed for the main activation foci. Furthermore, constraints from fMRI were used to identify the source activities of visual P300 ERP. Analysis of the hemodynamic response to the visual target stimuli revealed a distributed network of neural sources in the bilateral parietal lobules, middle and inferior frontal gyrus, precentral and postcentral cortex, and anterior cingulate gyrus. The analysis particularly showed preponderant activations of the bilateral superior parietal lobules. In this target detection design, two distinct P300 peaks were observed in the dipole waveforms, the bilateral prefrontal and the right inferior parietal dipole waveforms displayed the higher peak at short latency, while the four parietal, the anterior cingulate, and the temporal dipole waveforms had the higher peak at long latency. Compared with the classical oddball paradigm, the amplitude decreased in this study, which might be related to its particular stimulus context. The source technique was utilized to yield a realistic 11-dipole model and distinguish the anatomical generators of early and late components of the P300 response. © Med Sci Monit, 2009.en_HK
dc.languageengen_HK
dc.publisherMedical Science International Publishing. The Journal's web site is located at http://www.medscimonit.comen_HK
dc.relation.ispartofMedical Science Monitoren_HK
dc.subjectEEGen_HK
dc.subjectEvent related potentialen_HK
dc.subjectFMRIen_HK
dc.subjectHemodynamic responseen_HK
dc.subjectLandolt ring tasken_HK
dc.titleLocalizing P300 generators in high-density event-related potential with fMRIen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=3&volume=15&spage=MT47&epage=53.&date=2009&atitle=Localizing+P300+generators+in+high-density+event-+related+potential+with+fMRI.en_HK
dc.identifier.emailHu, Y:yhud@hku.hken_HK
dc.identifier.authorityHu, Y=rp00432en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid19247255en_HK
dc.identifier.scopuseid_2-s2.0-65349160333en_HK
dc.identifier.hkuros159711en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-65349160333&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue3en_HK
dc.identifier.spageMT47en_HK
dc.identifier.epageMT53en_HK
dc.identifier.isiWOS:000265280000021-
dc.publisher.placePolanden_HK
dc.identifier.scopusauthoridLi, Y=14052381600en_HK
dc.identifier.scopusauthoridLiQun Wang=26633079900en_HK
dc.identifier.scopusauthoridHu, Y=7407116091en_HK

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