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Article: Strontium-calcium coadministration stimulates bone matrix osteogenic factor expression and new bone formation in a large animal model

TitleStrontium-calcium coadministration stimulates bone matrix osteogenic factor expression and new bone formation in a large animal model
Authors
KeywordsCalcium
Goat
New bone formation
Osteoporosis
Strontium
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres
Citation
Journal Of Orthopaedic Research, 2009, v. 27 n. 6, p. 758-762 How to Cite?
AbstractStrontium (Sr) has become increasingly attractive for use in the prevention and treatment of osteoporosis by concomitantly inhibiting bone resorption and enhancing bone formation. Strontium shares similar chemical, physical, and biological characteristics with calcium (Ca), which has been widely used as a dietary supplement in osteoporosis. However, the effects of Sr-Ca coadministration on bone growth and remodeling are yet to be extensively reported. In this study, 18 ovariectomized goats were divided into four groups: three groups of five goats each treated with 100 mg/kg/day Ca, Ca plus 24 mg/kg/day Sr (Ca + 24Sr), or Ca plus 40 mg/kg/day Sr (Ca + 40Sr), and three untreated goats fed low calcium feed. Serum Sr levels increased 6- and 10-fold in the Ca + 24Sr and Ca + 40Sr groups, respectively. Similarly, Sr in the bone increased four- and sixfold in these two groups. Sr-Ca coadministration considerably increased bone mineral apposition rate (MAR). The expression of insulin-like growth factor (IGF)-1 and runt-related transcription factor 2 (Runx2) was significantly upregulated within the Ca + 40Sr treatment group; tumor necrosis factor (TNF)-agr; expression was significantly downregulated in the Ca and Ca + 40Sr groups. The results indicate that Sr-Ca coadministration increases osteogenic gene expression and stimulates new bone formation. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/59468
ISSN
2015 Impact Factor: 2.807
2015 SCImago Journal Rankings: 1.464
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Zen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorChiu, PKYen_HK
dc.contributor.authorLam, RWMen_HK
dc.contributor.authorXu, Ben_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorLeong, JCYen_HK
dc.contributor.authorLuk, KDKen_HK
dc.date.accessioned2010-05-31T03:50:50Z-
dc.date.available2010-05-31T03:50:50Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Orthopaedic Research, 2009, v. 27 n. 6, p. 758-762en_HK
dc.identifier.issn0736-0266en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59468-
dc.description.abstractStrontium (Sr) has become increasingly attractive for use in the prevention and treatment of osteoporosis by concomitantly inhibiting bone resorption and enhancing bone formation. Strontium shares similar chemical, physical, and biological characteristics with calcium (Ca), which has been widely used as a dietary supplement in osteoporosis. However, the effects of Sr-Ca coadministration on bone growth and remodeling are yet to be extensively reported. In this study, 18 ovariectomized goats were divided into four groups: three groups of five goats each treated with 100 mg/kg/day Ca, Ca plus 24 mg/kg/day Sr (Ca + 24Sr), or Ca plus 40 mg/kg/day Sr (Ca + 40Sr), and three untreated goats fed low calcium feed. Serum Sr levels increased 6- and 10-fold in the Ca + 24Sr and Ca + 40Sr groups, respectively. Similarly, Sr in the bone increased four- and sixfold in these two groups. Sr-Ca coadministration considerably increased bone mineral apposition rate (MAR). The expression of insulin-like growth factor (IGF)-1 and runt-related transcription factor 2 (Runx2) was significantly upregulated within the Ca + 40Sr treatment group; tumor necrosis factor (TNF)-agr; expression was significantly downregulated in the Ca and Ca + 40Sr groups. The results indicate that Sr-Ca coadministration increases osteogenic gene expression and stimulates new bone formation. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthresen_HK
dc.relation.ispartofJournal of Orthopaedic Researchen_HK
dc.rightsJournal of Orthopaedic Research. Copyright © John Wiley & Sons, Inc.-
dc.subjectCalciumen_HK
dc.subjectGoaten_HK
dc.subjectNew bone formationen_HK
dc.subjectOsteoporosisen_HK
dc.subjectStrontiumen_HK
dc.subject.meshAnimals-
dc.subject.meshBone Remodeling - drug effects - physiology-
dc.subject.meshCalcium - blood - pharmacology-
dc.subject.meshOsteoporosis - drug therapy - physiopathology - prevention and control-
dc.subject.meshStrontium - blood - pharmacology-
dc.titleStrontium-calcium coadministration stimulates bone matrix osteogenic factor expression and new bone formation in a large animal modelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0736-0266&volume=27&issue=6&spage=758&epage=762&date=2009&atitle=Strontium-calcium+coadministration+stimulates+bone+matrix+osteogenic+factor+expression+and+new+bone+formation+in+a+large+animal+modelen_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.emailChiu, PKY:pkychiu@hkucc.hku.hken_HK
dc.identifier.emailCheung, KMC:cheungmc@hku.hken_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityChiu, PKY=rp00379en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jor.20818en_HK
dc.identifier.pmid19025756-
dc.identifier.scopuseid_2-s2.0-66249124975en_HK
dc.identifier.hkuros166584en_HK
dc.identifier.hkuros158642-
dc.identifier.hkuros162543-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-66249124975&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue6en_HK
dc.identifier.spage758en_HK
dc.identifier.epage762en_HK
dc.identifier.isiWOS:000266123100010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, Z=35784563200en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridChiu, PKY=7202988127en_HK
dc.identifier.scopusauthoridLam, RWM=14625371400en_HK
dc.identifier.scopusauthoridXu, B=24752310700en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridLeong, JCY=35560782200en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK

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