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Article: Identification of amino acid substitutions in mutated peptides of nucleoprotein from avian influenza virus

TitleIdentification of amino acid substitutions in mutated peptides of nucleoprotein from avian influenza virus
Authors
KeywordsAmino acid substitution
H5N1 virus
Mutated peptide
Nanospray-MS/MS
Nucleoprotein
Issue Date2009
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/talanta
Citation
Talanta, 2009, v. 78 n. 4-5, p. 1492-1496 How to Cite?
AbstractNucleoprotein (NP), the structural component of ribonucleoprotein complex of avian influenza virus, performs multiple essential functions in the regulation of viral RNA synthesis and in the control of nuclear traffic of viral proteins. Mutations have often been found in NP, some of which are relevant to viral survival strategies. In this study, we used nanospray-MS/MS to analyze tryptic digestion of nucleoprotein of avian influenza virus (H5N1) and to identify three mutated peptides. The MS/MS analyses allowed the confident determination of the three mutated amino acid residues F313Y, I194V and V408I/L in the mutated peptides of LLQNSQVYSLIRPNENPAHK, GVGTMVMELVR and ASAGQI/LSVQPTFSVQR, respectively. © 2009 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59444
ISSN
2015 Impact Factor: 4.035
2015 SCImago Journal Rankings: 1.233
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Baptist UniversityFRG/07-08/11-21
Funding Information:

The authors would like to acknowledge financial support from the Faculty Research Grant (FRG/07-08/11-21) from Hong Kong Baptist University.

References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Nen_HK
dc.contributor.authorLee, KCen_HK
dc.contributor.authorSong, Wen_HK
dc.contributor.authorWang, Pen_HK
dc.contributor.authorCai, Zen_HK
dc.contributor.authorChen, Hen_HK
dc.date.accessioned2010-05-31T03:50:12Z-
dc.date.available2010-05-31T03:50:12Z-
dc.date.issued2009en_HK
dc.identifier.citationTalanta, 2009, v. 78 n. 4-5, p. 1492-1496en_HK
dc.identifier.issn0039-9140en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59444-
dc.description.abstractNucleoprotein (NP), the structural component of ribonucleoprotein complex of avian influenza virus, performs multiple essential functions in the regulation of viral RNA synthesis and in the control of nuclear traffic of viral proteins. Mutations have often been found in NP, some of which are relevant to viral survival strategies. In this study, we used nanospray-MS/MS to analyze tryptic digestion of nucleoprotein of avian influenza virus (H5N1) and to identify three mutated peptides. The MS/MS analyses allowed the confident determination of the three mutated amino acid residues F313Y, I194V and V408I/L in the mutated peptides of LLQNSQVYSLIRPNENPAHK, GVGTMVMELVR and ASAGQI/LSVQPTFSVQR, respectively. © 2009 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/talantaen_HK
dc.relation.ispartofTalantaen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsTalanta. Copyright © Elsevier BV.en_HK
dc.subjectAmino acid substitutionen_HK
dc.subjectH5N1 virusen_HK
dc.subjectMutated peptideen_HK
dc.subjectNanospray-MS/MSen_HK
dc.subjectNucleoproteinen_HK
dc.subject.meshInfluenza A Virus, H5N1 Subtype - genetics-
dc.subject.meshInfluenza in Birds - virology-
dc.subject.meshMutation, Missense-
dc.subject.meshNucleoproteins - genetics-
dc.subject.meshPeptide Fragments - genetics-
dc.titleIdentification of amino acid substitutions in mutated peptides of nucleoprotein from avian influenza virusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0039-9140&volume=78&issue=4-5&spage=1492&epage=1496&date=2009&atitle=Identification+of+amino+acid+substitutions+in+mutated+peptides+of+nucleoprotein+from+avian+influenza+virusen_HK
dc.identifier.emailChen, H:hlchen@hkucc.hku.hken_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.talanta.2009.01.057en_HK
dc.identifier.pmid19362222-
dc.identifier.scopuseid_2-s2.0-63949083467en_HK
dc.identifier.hkuros163960en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-63949083467&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume78en_HK
dc.identifier.issue4-5en_HK
dc.identifier.spage1492en_HK
dc.identifier.epage1496en_HK
dc.identifier.isiWOS:000266055400044-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLiu, N=36079934800en_HK
dc.identifier.scopusauthoridLee, KC=14060567400en_HK
dc.identifier.scopusauthoridSong, W=23490429800en_HK
dc.identifier.scopusauthoridWang, P=13907209900en_HK
dc.identifier.scopusauthoridCai, Z=7402904946en_HK
dc.identifier.scopusauthoridChen, H=26643315400en_HK

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