Article: Systemic infection of avian influenza A virus H5N1 subtype in humans

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TitleSystemic infection of avian influenza A virus H5N1 subtype in humans
AuthorsZhang, Z2 3
Zhang, J2
Huang, K2
Li, KS3
Yuen, KY2
Guan, Y2 3
Chen, H2 3
Ng, WF1
KeywordsAvian influenza A virus
H5N1 subtype
Human infection
Immunohistochemistry
Tissue tropism
Issue Date2009
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
CitationHuman Pathology, 2009, v. 40 n. 5, p. 735-739 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.humpath.2008.08.015
AbstractThe viral dissemination in a patient with avian influenza A subtype H5N1 infection was retrospectively studied by the immunohistochemical localization of viral nucleoprotein antigen. The pathology was marked by diffuse alveolar damage, lymphoid depletion, and reactive hemophagocytic syndrome. Besides the lung and the upper respiratory tract, viral antigen was detected in the small and large intestinal epithelial cells, hematopoietic cells in the bone marrow, glial cells and neurons of the brain, and lymphocytes. The results confirmed that H5N1 virus disseminated to multiple organs beyond the respiratory system. However, specific pathological changes were noted in the respiratory system only, and productive viral replication confirmed by culture was noted only in the lung. More postmortem studies are needed to elucidate the pathogenesis of this highly fatal zoonotic disease. © 2009 Elsevier Inc. All rights reserved.
ISSN0046-8177
2011 Impact Factor: 2.876
2011 SCImago Journal Rankings: 0.343
DOIhttp://dx.doi.org/10.1016/j.humpath.2008.08.015
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorZhang, Z
dc.contributor.authorZhang, J
dc.contributor.authorHuang, K
dc.contributor.authorLi, KS
dc.contributor.authorYuen, KY
dc.contributor.authorGuan, Y
dc.contributor.authorChen, H
dc.contributor.authorNg, WF
dc.date.accessioned2010-05-31T03:50:10Z
dc.date.available2010-05-31T03:50:10Z
dc.date.issued2009
dc.description.abstractThe viral dissemination in a patient with avian influenza A subtype H5N1 infection was retrospectively studied by the immunohistochemical localization of viral nucleoprotein antigen. The pathology was marked by diffuse alveolar damage, lymphoid depletion, and reactive hemophagocytic syndrome. Besides the lung and the upper respiratory tract, viral antigen was detected in the small and large intestinal epithelial cells, hematopoietic cells in the bone marrow, glial cells and neurons of the brain, and lymphocytes. The results confirmed that H5N1 virus disseminated to multiple organs beyond the respiratory system. However, specific pathological changes were noted in the respiratory system only, and productive viral replication confirmed by culture was noted only in the lung. More postmortem studies are needed to elucidate the pathogenesis of this highly fatal zoonotic disease. © 2009 Elsevier Inc. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationHuman Pathology, 2009, v. 40 n. 5, p. 735-739 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.humpath.2008.08.015
dc.identifier.doihttp://dx.doi.org/10.1016/j.humpath.2008.08.015
dc.identifier.epage739
dc.identifier.hkuros163961
dc.identifier.isiWOS:000265434900017
Funding AgencyGrant Number
Research Grant CouncilHKU 74888/05M
7500/06M
Research Fund for the Control of infectious Diseases from Health, Welfare and Food Bureau, Government of Hong Kong SAR
Li Ka Shing Foundation
Providence Foundation Limited
Funding Information:

Research Grant Council (HKU 74888/05M and 7500/06M) and Research Fund for the Control of infectious Diseases from Health, Welfare and Food Bureau, Government of Hong Kong SAR, Li Ka Shing Foundation and the Providence Foundation Limited in memory of the late Dr Liu Hac Minh.

dc.identifier.issn0046-8177
2011 Impact Factor: 2.876
2011 SCImago Journal Rankings: 0.343
dc.identifier.issue5
dc.identifier.openurl
dc.identifier.pmid19121843
dc.identifier.scopuseid_2-s2.0-64449083389
dc.identifier.spage735
dc.identifier.urihttp://hdl.handle.net/10722/59442
dc.identifier.volume40
dc.languageeng
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
dc.publisher.placeUnited States
dc.relation.ispartofHuman Pathology
dc.relation.referencesReferences in Scopus
dc.subject.meshAntigens, Viral - analysis
dc.subject.meshAstrocytes - virology
dc.subject.meshBlotting, Western
dc.subject.meshInfluenza A Virus, H5N1 Subtype - isolation and purification
dc.subject.meshInfluenza, Human - pathology - physiopathology - virology
dc.subjectAvian influenza A virus
dc.subjectH5N1 subtype
dc.subjectHuman infection
dc.subjectImmunohistochemistry
dc.subjectTissue tropism
dc.titleSystemic infection of avian influenza A virus H5N1 subtype in humans
dc.typeArticle
Author Affiliations
  1. Hong Kong Hospital Authority
  2. Research Centre of Infection and Immunology
  3. Shantou University, Medical College (SUMC)