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- Publisher Website: 10.1016/j.humpath.2008.08.015
- Scopus: eid_2-s2.0-64449083389
- PMID: 19121843
- WOS: WOS:000265434900017
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Article: Systemic infection of avian influenza A virus H5N1 subtype in humans
Title | Systemic infection of avian influenza A virus H5N1 subtype in humans | ||||||||||
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Authors | |||||||||||
Keywords | Avian influenza A virus H5N1 subtype Human infection Immunohistochemistry Tissue tropism | ||||||||||
Issue Date | 2009 | ||||||||||
Publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath | ||||||||||
Citation | Human Pathology, 2009, v. 40 n. 5, p. 735-739 How to Cite? | ||||||||||
Abstract | The viral dissemination in a patient with avian influenza A subtype H5N1 infection was retrospectively studied by the immunohistochemical localization of viral nucleoprotein antigen. The pathology was marked by diffuse alveolar damage, lymphoid depletion, and reactive hemophagocytic syndrome. Besides the lung and the upper respiratory tract, viral antigen was detected in the small and large intestinal epithelial cells, hematopoietic cells in the bone marrow, glial cells and neurons of the brain, and lymphocytes. The results confirmed that H5N1 virus disseminated to multiple organs beyond the respiratory system. However, specific pathological changes were noted in the respiratory system only, and productive viral replication confirmed by culture was noted only in the lung. More postmortem studies are needed to elucidate the pathogenesis of this highly fatal zoonotic disease. © 2009 Elsevier Inc. All rights reserved. | ||||||||||
Persistent Identifier | http://hdl.handle.net/10722/59442 | ||||||||||
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.936 | ||||||||||
ISI Accession Number ID |
Funding Information: Research Grant Council (HKU 74888/05M and 7500/06M) and Research Fund for the Control of infectious Diseases from Health, Welfare and Food Bureau, Government of Hong Kong SAR, Li Ka Shing Foundation and the Providence Foundation Limited in memory of the late Dr Liu Hac Minh. | ||||||||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, Z | en_HK |
dc.contributor.author | Zhang, J | en_HK |
dc.contributor.author | Huang, K | en_HK |
dc.contributor.author | Li, KS | en_HK |
dc.contributor.author | Yuen, KY | en_HK |
dc.contributor.author | Guan, Y | en_HK |
dc.contributor.author | Chen, H | en_HK |
dc.contributor.author | Ng, WF | en_HK |
dc.date.accessioned | 2010-05-31T03:50:10Z | - |
dc.date.available | 2010-05-31T03:50:10Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | Human Pathology, 2009, v. 40 n. 5, p. 735-739 | en_HK |
dc.identifier.issn | 0046-8177 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/59442 | - |
dc.description.abstract | The viral dissemination in a patient with avian influenza A subtype H5N1 infection was retrospectively studied by the immunohistochemical localization of viral nucleoprotein antigen. The pathology was marked by diffuse alveolar damage, lymphoid depletion, and reactive hemophagocytic syndrome. Besides the lung and the upper respiratory tract, viral antigen was detected in the small and large intestinal epithelial cells, hematopoietic cells in the bone marrow, glial cells and neurons of the brain, and lymphocytes. The results confirmed that H5N1 virus disseminated to multiple organs beyond the respiratory system. However, specific pathological changes were noted in the respiratory system only, and productive viral replication confirmed by culture was noted only in the lung. More postmortem studies are needed to elucidate the pathogenesis of this highly fatal zoonotic disease. © 2009 Elsevier Inc. All rights reserved. | en_HK |
dc.language | eng | en_HK |
dc.publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath | en_HK |
dc.relation.ispartof | Human Pathology | en_HK |
dc.subject | Avian influenza A virus | en_HK |
dc.subject | H5N1 subtype | en_HK |
dc.subject | Human infection | en_HK |
dc.subject | Immunohistochemistry | en_HK |
dc.subject | Tissue tropism | en_HK |
dc.subject.mesh | Antigens, Viral - analysis | - |
dc.subject.mesh | Astrocytes - virology | - |
dc.subject.mesh | Blotting, Western | - |
dc.subject.mesh | Influenza A Virus, H5N1 Subtype - isolation and purification | - |
dc.subject.mesh | Influenza, Human - pathology - physiopathology - virology | - |
dc.title | Systemic infection of avian influenza A virus H5N1 subtype in humans | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=40&spage=735&epage=739&date=2009&atitle=Systemic+infection+of+avian+influenza+A+virus+H5N1+subtype+in+human | en_HK |
dc.identifier.email | Zhang, J: zhangajx@hkucc.hku.hk | en_HK |
dc.identifier.email | Yuen, KY: kyyuen@hkucc.hku.hk | en_HK |
dc.identifier.email | Guan, Y: yguan@hkucc.hku.hk | en_HK |
dc.identifier.email | Chen, H: hlchen@hku.hk | en_HK |
dc.identifier.authority | Zhang, J=rp00413 | en_HK |
dc.identifier.authority | Yuen, KY=rp00366 | en_HK |
dc.identifier.authority | Guan, Y=rp00397 | en_HK |
dc.identifier.authority | Chen, H=rp00383 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.humpath.2008.08.015 | en_HK |
dc.identifier.pmid | 19121843 | - |
dc.identifier.scopus | eid_2-s2.0-64449083389 | en_HK |
dc.identifier.hkuros | 163961 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-64449083389&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 40 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 735 | en_HK |
dc.identifier.epage | 739 | en_HK |
dc.identifier.isi | WOS:000265434900017 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Zhang, Z=25930204600 | en_HK |
dc.identifier.scopusauthorid | Zhang, J=12752135600 | en_HK |
dc.identifier.scopusauthorid | Huang, K=44961130600 | en_HK |
dc.identifier.scopusauthorid | Li, KS=36072420200 | en_HK |
dc.identifier.scopusauthorid | Yuen, KY=36078079100 | en_HK |
dc.identifier.scopusauthorid | Guan, Y=7202924055 | en_HK |
dc.identifier.scopusauthorid | Chen, H=26643315400 | en_HK |
dc.identifier.scopusauthorid | Ng, WF=7401613384 | en_HK |
dc.identifier.issnl | 0046-8177 | - |