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Article: Immunogenicity and safety of intradermal versus intramuscular route of influenza immunization in infants less than 6 months of age: A randomized controlled trial

TitleImmunogenicity and safety of intradermal versus intramuscular route of influenza immunization in infants less than 6 months of age: A randomized controlled trial
Authors
KeywordsIntradermal influenza vaccination
Young infants
Issue Date2009
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccine
Citation
Vaccine, 2009, v. 27 n. 35, p. 4834-4839 How to Cite?
AbstractWe aimed to explore intradermal influenza vaccination in infants <6 months. One hundred twenty-six infants 2-3 months of age were randomized to receive either two doses, 1 month apart, of 0.25 ml of a trivalent inactivated influenza vaccine (7.5 μg of hemagglutinin per strain) via the intramuscular (IM) route or 0.1 ml of the same vaccine (3 μg of hemagglutinin per strain) via the intradermal (ID) route. The vaccine was well tolerated. Only four infants had hemagglutination inhibition (HAI) titer <40 against ≥1 vaccine-covered antigen pre-vaccination. There was no difference in fold-rise of HAI titer response between those in the IM or ID group. We documented maintenance of HAI titers above seroprotective levels against all three vaccine antigens in 97.6% of subjects regardless of vaccination methods over a time of waning maternal antibodies. © 2009 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59424
ISSN
2015 Impact Factor: 3.413
2015 SCImago Journal Rankings: 2.044
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of Hong KongHKU763707M
Area of Excellence Scheme of the University Grants CommitteeAoE/M-12/06
Hong Kong SAR Government
Funding Information:

We acknowledge research grants from the Research Grants Council of Hong Kong (HKU763707M) and the Area of Excellence Scheme of the University Grants Committee (Grant AoE/M-12/06) of the Hong Kong SAR Government. We thank Ms. Winnie WS Lau for single-handedly performing all the intradermal vaccination, and Ms. Eunice LY Chan for assisting in the study coordination.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorChiu, SSen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorTu, Wen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.date.accessioned2010-05-31T03:49:49Z-
dc.date.available2010-05-31T03:49:49Z-
dc.date.issued2009en_HK
dc.identifier.citationVaccine, 2009, v. 27 n. 35, p. 4834-4839en_HK
dc.identifier.issn0264-410Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/59424-
dc.description.abstractWe aimed to explore intradermal influenza vaccination in infants <6 months. One hundred twenty-six infants 2-3 months of age were randomized to receive either two doses, 1 month apart, of 0.25 ml of a trivalent inactivated influenza vaccine (7.5 μg of hemagglutinin per strain) via the intramuscular (IM) route or 0.1 ml of the same vaccine (3 μg of hemagglutinin per strain) via the intradermal (ID) route. The vaccine was well tolerated. Only four infants had hemagglutination inhibition (HAI) titer <40 against ≥1 vaccine-covered antigen pre-vaccination. There was no difference in fold-rise of HAI titer response between those in the IM or ID group. We documented maintenance of HAI titers above seroprotective levels against all three vaccine antigens in 97.6% of subjects regardless of vaccination methods over a time of waning maternal antibodies. © 2009 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/vaccineen_HK
dc.relation.ispartofVaccineen_HK
dc.rightsVaccine. Copyright © Elsevier Ltd.en_HK
dc.subjectIntradermal influenza vaccinationen_HK
dc.subjectYoung infantsen_HK
dc.titleImmunogenicity and safety of intradermal versus intramuscular route of influenza immunization in infants less than 6 months of age: A randomized controlled trialen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0264-410X&volume=doi:10.1016&spage=J.vaccine.2009.05.066&epage=&date=2009&atitle=Immunogenicity+and+safety+of+intradermal+versus+intramuscular+route+of+influenza+immunization+in+infants+less+than+6+months+of+age:+a+randomized+controlled+trialen_HK
dc.identifier.emailChiu, SS: ssschiu@hku.hken_HK
dc.identifier.emailTu, W: wwtu@hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authorityChiu, SS=rp00421en_HK
dc.identifier.authorityTu, W=rp00416en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.vaccine.2009.05.066en_HK
dc.identifier.pmid19523908-
dc.identifier.scopuseid_2-s2.0-67650224009en_HK
dc.identifier.hkuros157588en_HK
dc.identifier.hkuros179391-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67650224009&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue35en_HK
dc.identifier.spage4834en_HK
dc.identifier.epage4839en_HK
dc.identifier.isiWOS:000268827500016-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridChiu, SS=7202291500en_HK
dc.identifier.scopusauthoridChan, KH=7406034307en_HK
dc.identifier.scopusauthoridTu, W=7006479236en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.citeulike4990588-

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