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Article: Emergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humans

TitleEmergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humans
Authors
KeywordsDiagnostics
Epidemiology
Evolution
H1N1
Influenza
Novel
Swine
Issue Date2009
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcv
Citation
Journal Of Clinical Virology, 2009, v. 45 n. 3, p. 169-173 How to Cite?
AbstractA recently emerged novel influenza A H1N1 virus continues to spread globally. The virus contains a novel constellation of gene segments, the nearest known precursors being viruses found in swine and it likely arose through reassortment of two or more viruses of swine origin. H1N1, H1N2 and H3N2 subtype swine influenza viruses have occasionally infected humans before but such zoonotic transmission events did not lead to sustained human-to-human transmission in the manner this swine-origin influenza virus (S-OIV) has done. Its transmission among humans appears to be higher than that observed with seasonal influenza. Children and young adults appear to those most affected and also those who appear to maintain transmission. Clinical disease generally appears mild but complications leading to hospitalization can occur, especially in those with underlying lung or cardiac disease, diabetes or those on immunosuppresive therapies. There are concerns that the virus may reassort with existing human influenza virus giving rise to more transmissible or more pathogenic viruses. The virus appears to retain the potential to transmit back to swine and thus continued reassortment with swine viruses is a cause for concern. © 2009 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59414
ISSN
2015 Impact Factor: 2.647
2015 SCImago Journal Rankings: 1.503
ISI Accession Number ID
Funding AgencyGrant Number
Area of Excellence Scheme of the University Grants Committee Hong KongAoE/M12/06
National Institutes of HealthHHSN266200700005C
Funding Information:

This work was supported by the Area of Excellence Scheme of the University Grants Committee Hong Kong Grant AoE/M12/06 and the National Institutes of Health (NIAID contract HHSN266200700005C).

References

 

DC FieldValueLanguage
dc.contributor.authorMalik Peiris, JSen_HK
dc.contributor.authorPoon, LLMen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2010-05-31T03:49:37Z-
dc.date.available2010-05-31T03:49:37Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Clinical Virology, 2009, v. 45 n. 3, p. 169-173en_HK
dc.identifier.issn1386-6532en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59414-
dc.description.abstractA recently emerged novel influenza A H1N1 virus continues to spread globally. The virus contains a novel constellation of gene segments, the nearest known precursors being viruses found in swine and it likely arose through reassortment of two or more viruses of swine origin. H1N1, H1N2 and H3N2 subtype swine influenza viruses have occasionally infected humans before but such zoonotic transmission events did not lead to sustained human-to-human transmission in the manner this swine-origin influenza virus (S-OIV) has done. Its transmission among humans appears to be higher than that observed with seasonal influenza. Children and young adults appear to those most affected and also those who appear to maintain transmission. Clinical disease generally appears mild but complications leading to hospitalization can occur, especially in those with underlying lung or cardiac disease, diabetes or those on immunosuppresive therapies. There are concerns that the virus may reassort with existing human influenza virus giving rise to more transmissible or more pathogenic viruses. The virus appears to retain the potential to transmit back to swine and thus continued reassortment with swine viruses is a cause for concern. © 2009 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcven_HK
dc.relation.ispartofJournal of Clinical Virologyen_HK
dc.subjectDiagnosticsen_HK
dc.subjectEpidemiologyen_HK
dc.subjectEvolutionen_HK
dc.subjectH1N1en_HK
dc.subjectInfluenzaen_HK
dc.subjectNovelen_HK
dc.subjectSwineen_HK
dc.subject.meshAge Factors-
dc.subject.meshAnimals-
dc.subject.meshInfluenza A Virus, H1N1 Subtype - genetics - isolation and purification - pathogenicity-
dc.subject.meshInfluenza, Human - epidemiology - transmission - virology-
dc.subject.meshReassortant Viruses - genetics - isolation and purification - pathogenicity-
dc.titleEmergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humansen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1386-6532&volume=45&issue=3&spage=169&epage=173&date=2009&atitle=Emergence+of+a+novel+swine-origin+influenza+A+virus+(S-OIV)+H1N1+virus+in+humansen_HK
dc.identifier.emailMalik Peiris, JS: malik@hkucc.hku.hken_HK
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authorityMalik Peiris, JS=rp00410en_HK
dc.identifier.authorityPoon, LLM=rp00484en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jcv.2009.06.006en_HK
dc.identifier.pmid19540800-
dc.identifier.scopuseid_2-s2.0-67649227029en_HK
dc.identifier.hkuros164352en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67649227029&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume45en_HK
dc.identifier.issue3en_HK
dc.identifier.spage169en_HK
dc.identifier.epage173en_HK
dc.identifier.isiWOS:000268401800002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridMalik Peiris, JS=7005486823en_HK
dc.identifier.scopusauthoridPoon, LLM=7005441747en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.citeulike5268451-

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