Article: Analyses of fluoroquinolones and Clostridium difficile-associated diarrhoea in tuberculosis patients

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TitleAnalyses of fluoroquinolones and Clostridium difficile-associated diarrhoea in tuberculosis patients
AuthorsChang, KC2 3
Leung, CC2
Yew, WW4
Lam, FM4
Ho, PL1
Chau, CH4
Cheng, VCC1
Yuen, KY1
Issue Date2009
PublisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
CitationInternational Journal Of Tuberculosis And Lung Disease, 2009, v. 13 n. 3, p. 341-346 [How to Cite?]
AbstractSETTING: Systematic studies of fluoroquinolones (FQs) and Clostridium difficile-associated diarrhoea (CDAD) are scarce among tuberculosis (TB) patients, in whom fluoroquinolones (FQs) are increasingly used. OBJECTIVE: To evaluate the relationship between FQs and CDAD among TB patients. DESIGN: Retrospective cohort and nested case-control analyses were conducted among 3319 hospital patients on anti-tuberculosis treatment from 1999 to 2005. Each case of CDAD was matched by three sex- and age-matched controls randomly selected from the rest of the cohort. Not every case was confirmed by C. difficile cytotoxins. RESULTS: Among 38 cases studied, the incidence of CDAD, which was 28.2 (95%CI 20.3-38.3) per 100 000 patient-days overall, increased from 12.9 (95%CI 5.8-25.3) for patients aged <60 years to 26.6 (95%CI 15.5-42.8) for those aged between 60 and 79 years, and 66.9 (95%CI 39.8-106.1) for those aged >79 years. Univariate analysis showed a significant association between CDAD and age, FQs, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. Only duration of hospital stay and nasogastric feeding remained significant on multivariable analysis. CONCLUSION: The risk of CDAD due to FQs among TB patients is probably modest after controlling for sex, age, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. © 2009 The Union.
ISSN1027-3719
2011 Impact Factor: 2.731
2011 SCImago Journal Rankings: 0.249
ISI Accession Number IDWOS:000263846700011
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChang, KC
dc.contributor.authorLeung, CC
dc.contributor.authorYew, WW
dc.contributor.authorLam, FM
dc.contributor.authorHo, PL
dc.contributor.authorChau, CH
dc.contributor.authorCheng, VCC
dc.contributor.authorYuen, KY
dc.date.accessioned2010-05-31T03:49:34Z
dc.date.available2010-05-31T03:49:34Z
dc.date.issued2009
dc.description.abstractSETTING: Systematic studies of fluoroquinolones (FQs) and Clostridium difficile-associated diarrhoea (CDAD) are scarce among tuberculosis (TB) patients, in whom fluoroquinolones (FQs) are increasingly used. OBJECTIVE: To evaluate the relationship between FQs and CDAD among TB patients. DESIGN: Retrospective cohort and nested case-control analyses were conducted among 3319 hospital patients on anti-tuberculosis treatment from 1999 to 2005. Each case of CDAD was matched by three sex- and age-matched controls randomly selected from the rest of the cohort. Not every case was confirmed by C. difficile cytotoxins. RESULTS: Among 38 cases studied, the incidence of CDAD, which was 28.2 (95%CI 20.3-38.3) per 100 000 patient-days overall, increased from 12.9 (95%CI 5.8-25.3) for patients aged <60 years to 26.6 (95%CI 15.5-42.8) for those aged between 60 and 79 years, and 66.9 (95%CI 39.8-106.1) for those aged >79 years. Univariate analysis showed a significant association between CDAD and age, FQs, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. Only duration of hospital stay and nasogastric feeding remained significant on multivariable analysis. CONCLUSION: The risk of CDAD due to FQs among TB patients is probably modest after controlling for sex, age, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. © 2009 The Union.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationInternational Journal Of Tuberculosis And Lung Disease, 2009, v. 13 n. 3, p. 341-346 [How to Cite?]
dc.identifier.epage346
dc.identifier.hkuros167104
dc.identifier.isiWOS:000263846700011
dc.identifier.issn1027-3719
2011 Impact Factor: 2.731
2011 SCImago Journal Rankings: 0.249
dc.identifier.issue3
dc.identifier.pmid19275794
dc.identifier.scopuseid_2-s2.0-62349102110
dc.identifier.spage341
dc.identifier.urihttp://hdl.handle.net/10722/59412
dc.identifier.volume13
dc.languageeng
dc.publisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
dc.publisher.placeFrance
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Disease
dc.relation.referencesReferences in Scopus
dc.subject.meshAged
dc.subject.meshAnti-Bacterial Agents - adverse effects - therapeutic use
dc.subject.meshCase-Control Studies
dc.subject.meshClostridium Infections - epidemiology - etiology
dc.subject.meshComorbidity
dc.subject.meshDiarrhea - microbiology
dc.subject.meshEnteral Nutrition
dc.subject.meshFemale
dc.subject.meshFluoroquinolones - adverse effects - therapeutic use
dc.subject.meshHumans
dc.subject.meshLength of Stay
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshTuberculosis, Pulmonary - drug therapy - epidemiology
dc.titleAnalyses of fluoroquinolones and Clostridium difficile-associated diarrhoea in tuberculosis patients
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Centre for Health Protection
  3. Wanchai Chest Clinic
  4. Grantham Hospital Hong Kong