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Article: Analyses of fluoroquinolones and Clostridium difficile-associated diarrhoea in tuberculosis patients

TitleAnalyses of fluoroquinolones and Clostridium difficile-associated diarrhoea in tuberculosis patients
Authors
Issue Date2009
PublisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
Citation
International Journal Of Tuberculosis And Lung Disease, 2009, v. 13 n. 3, p. 341-346 How to Cite?
AbstractSETTING: Systematic studies of fluoroquinolones (FQs) and Clostridium difficile-associated diarrhoea (CDAD) are scarce among tuberculosis (TB) patients, in whom fluoroquinolones (FQs) are increasingly used. OBJECTIVE: To evaluate the relationship between FQs and CDAD among TB patients. DESIGN: Retrospective cohort and nested case-control analyses were conducted among 3319 hospital patients on anti-tuberculosis treatment from 1999 to 2005. Each case of CDAD was matched by three sex- and age-matched controls randomly selected from the rest of the cohort. Not every case was confirmed by C. difficile cytotoxins. RESULTS: Among 38 cases studied, the incidence of CDAD, which was 28.2 (95%CI 20.3-38.3) per 100 000 patient-days overall, increased from 12.9 (95%CI 5.8-25.3) for patients aged <60 years to 26.6 (95%CI 15.5-42.8) for those aged between 60 and 79 years, and 66.9 (95%CI 39.8-106.1) for those aged >79 years. Univariate analysis showed a significant association between CDAD and age, FQs, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. Only duration of hospital stay and nasogastric feeding remained significant on multivariable analysis. CONCLUSION: The risk of CDAD due to FQs among TB patients is probably modest after controlling for sex, age, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. © 2009 The Union.
Persistent Identifierhttp://hdl.handle.net/10722/59412
ISSN
2015 Impact Factor: 2.148
2015 SCImago Journal Rankings: 1.381
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChang, KCen_HK
dc.contributor.authorLeung, CCen_HK
dc.contributor.authorYew, WWen_HK
dc.contributor.authorLam, FMen_HK
dc.contributor.authorHo, PLen_HK
dc.contributor.authorChau, CHen_HK
dc.contributor.authorCheng, VCCen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2010-05-31T03:49:34Z-
dc.date.available2010-05-31T03:49:34Z-
dc.date.issued2009en_HK
dc.identifier.citationInternational Journal Of Tuberculosis And Lung Disease, 2009, v. 13 n. 3, p. 341-346en_HK
dc.identifier.issn1027-3719en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59412-
dc.description.abstractSETTING: Systematic studies of fluoroquinolones (FQs) and Clostridium difficile-associated diarrhoea (CDAD) are scarce among tuberculosis (TB) patients, in whom fluoroquinolones (FQs) are increasingly used. OBJECTIVE: To evaluate the relationship between FQs and CDAD among TB patients. DESIGN: Retrospective cohort and nested case-control analyses were conducted among 3319 hospital patients on anti-tuberculosis treatment from 1999 to 2005. Each case of CDAD was matched by three sex- and age-matched controls randomly selected from the rest of the cohort. Not every case was confirmed by C. difficile cytotoxins. RESULTS: Among 38 cases studied, the incidence of CDAD, which was 28.2 (95%CI 20.3-38.3) per 100 000 patient-days overall, increased from 12.9 (95%CI 5.8-25.3) for patients aged <60 years to 26.6 (95%CI 15.5-42.8) for those aged between 60 and 79 years, and 66.9 (95%CI 39.8-106.1) for those aged >79 years. Univariate analysis showed a significant association between CDAD and age, FQs, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. Only duration of hospital stay and nasogastric feeding remained significant on multivariable analysis. CONCLUSION: The risk of CDAD due to FQs among TB patients is probably modest after controlling for sex, age, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. © 2009 The Union.en_HK
dc.languageengen_HK
dc.publisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.htmlen_HK
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Diseaseen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAnti-Bacterial Agents - adverse effects - therapeutic useen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshClostridium Infections - epidemiology - etiologyen_HK
dc.subject.meshComorbidityen_HK
dc.subject.meshDiarrhea - microbiologyen_HK
dc.subject.meshEnteral Nutritionen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFluoroquinolones - adverse effects - therapeutic useen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLength of Stayen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshTuberculosis, Pulmonary - drug therapy - epidemiologyen_HK
dc.titleAnalyses of fluoroquinolones and Clostridium difficile-associated diarrhoea in tuberculosis patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid19275794-
dc.identifier.scopuseid_2-s2.0-62349102110en_HK
dc.identifier.hkuros167104en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-62349102110&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue3en_HK
dc.identifier.spage341en_HK
dc.identifier.epage346en_HK
dc.identifier.isiWOS:000263846700011-
dc.publisher.placeFranceen_HK
dc.identifier.scopusauthoridChang, KC=35387873600en_HK
dc.identifier.scopusauthoridLeung, CC=7402612644en_HK
dc.identifier.scopusauthoridYew, WW=7005934631en_HK
dc.identifier.scopusauthoridLam, FM=7102075928en_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridChau, CH=7102320975en_HK
dc.identifier.scopusauthoridCheng, VCC=23670479400en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

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