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Article: Analyses of fluoroquinolones and Clostridium difficile-associated diarrhoea in tuberculosis patients

TitleAnalyses of fluoroquinolones and Clostridium difficile-associated diarrhoea in tuberculosis patients
Authors
Issue Date2009
PublisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
Citation
International Journal Of Tuberculosis And Lung Disease, 2009, v. 13 n. 3, p. 341-346 How to Cite?
Abstract
SETTING: Systematic studies of fluoroquinolones (FQs) and Clostridium difficile-associated diarrhoea (CDAD) are scarce among tuberculosis (TB) patients, in whom fluoroquinolones (FQs) are increasingly used. OBJECTIVE: To evaluate the relationship between FQs and CDAD among TB patients. DESIGN: Retrospective cohort and nested case-control analyses were conducted among 3319 hospital patients on anti-tuberculosis treatment from 1999 to 2005. Each case of CDAD was matched by three sex- and age-matched controls randomly selected from the rest of the cohort. Not every case was confirmed by C. difficile cytotoxins. RESULTS: Among 38 cases studied, the incidence of CDAD, which was 28.2 (95%CI 20.3-38.3) per 100 000 patient-days overall, increased from 12.9 (95%CI 5.8-25.3) for patients aged <60 years to 26.6 (95%CI 15.5-42.8) for those aged between 60 and 79 years, and 66.9 (95%CI 39.8-106.1) for those aged >79 years. Univariate analysis showed a significant association between CDAD and age, FQs, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. Only duration of hospital stay and nasogastric feeding remained significant on multivariable analysis. CONCLUSION: The risk of CDAD due to FQs among TB patients is probably modest after controlling for sex, age, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. © 2009 The Union.
Persistent Identifierhttp://hdl.handle.net/10722/59412
ISSN
2013 Impact Factor: 2.756
2013 SCImago Journal Rankings: 1.527
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Centre for Health Protection
  3. Wanchai Chest Clinic
  4. Grantham Hospital Hong Kong
DC FieldValueLanguage
dc.contributor.authorChang, KCen_HK
dc.contributor.authorLeung, CCen_HK
dc.contributor.authorYew, WWen_HK
dc.contributor.authorLam, FMen_HK
dc.contributor.authorHo, PLen_HK
dc.contributor.authorChau, CHen_HK
dc.contributor.authorCheng, VCCen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2010-05-31T03:49:34Z-
dc.date.available2010-05-31T03:49:34Z-
dc.date.issued2009en_HK
dc.identifier.citationInternational Journal Of Tuberculosis And Lung Disease, 2009, v. 13 n. 3, p. 341-346en_HK
dc.identifier.issn1027-3719en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59412-
dc.description.abstractSETTING: Systematic studies of fluoroquinolones (FQs) and Clostridium difficile-associated diarrhoea (CDAD) are scarce among tuberculosis (TB) patients, in whom fluoroquinolones (FQs) are increasingly used. OBJECTIVE: To evaluate the relationship between FQs and CDAD among TB patients. DESIGN: Retrospective cohort and nested case-control analyses were conducted among 3319 hospital patients on anti-tuberculosis treatment from 1999 to 2005. Each case of CDAD was matched by three sex- and age-matched controls randomly selected from the rest of the cohort. Not every case was confirmed by C. difficile cytotoxins. RESULTS: Among 38 cases studied, the incidence of CDAD, which was 28.2 (95%CI 20.3-38.3) per 100 000 patient-days overall, increased from 12.9 (95%CI 5.8-25.3) for patients aged <60 years to 26.6 (95%CI 15.5-42.8) for those aged between 60 and 79 years, and 66.9 (95%CI 39.8-106.1) for those aged >79 years. Univariate analysis showed a significant association between CDAD and age, FQs, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. Only duration of hospital stay and nasogastric feeding remained significant on multivariable analysis. CONCLUSION: The risk of CDAD due to FQs among TB patients is probably modest after controlling for sex, age, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. © 2009 The Union.en_HK
dc.languageengen_HK
dc.publisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.htmlen_HK
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Diseaseen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAnti-Bacterial Agents - adverse effects - therapeutic useen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshClostridium Infections - epidemiology - etiologyen_HK
dc.subject.meshComorbidityen_HK
dc.subject.meshDiarrhea - microbiologyen_HK
dc.subject.meshEnteral Nutritionen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFluoroquinolones - adverse effects - therapeutic useen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLength of Stayen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshTuberculosis, Pulmonary - drug therapy - epidemiologyen_HK
dc.titleAnalyses of fluoroquinolones and Clostridium difficile-associated diarrhoea in tuberculosis patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid19275794en_HK
dc.identifier.scopuseid_2-s2.0-62349102110en_HK
dc.identifier.hkuros167104en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-62349102110&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue3en_HK
dc.identifier.spage341en_HK
dc.identifier.epage346en_HK
dc.identifier.isiWOS:000263846700011-
dc.publisher.placeFranceen_HK
dc.identifier.scopusauthoridChang, KC=35387873600en_HK
dc.identifier.scopusauthoridLeung, CC=7402612644en_HK
dc.identifier.scopusauthoridYew, WW=7005934631en_HK
dc.identifier.scopusauthoridLam, FM=7102075928en_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridChau, CH=7102320975en_HK
dc.identifier.scopusauthoridCheng, VCC=23670479400en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

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