File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Analyses of fluoroquinolones and Clostridium difficile-associated diarrhoea in tuberculosis patients
  • Basic View
  • Metadata View
  • XML View
TitleAnalyses of fluoroquinolones and Clostridium difficile-associated diarrhoea in tuberculosis patients
 
AuthorsChang, KC2 3
Leung, CC2
Yew, WW4
Lam, FM4
Ho, PL1
Chau, CH4
Cheng, VCC1
Yuen, KY1
 
Issue Date2009
 
PublisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
 
CitationInternational Journal Of Tuberculosis And Lung Disease, 2009, v. 13 n. 3, p. 341-346 [How to Cite?]
 
AbstractSETTING: Systematic studies of fluoroquinolones (FQs) and Clostridium difficile-associated diarrhoea (CDAD) are scarce among tuberculosis (TB) patients, in whom fluoroquinolones (FQs) are increasingly used. OBJECTIVE: To evaluate the relationship between FQs and CDAD among TB patients. DESIGN: Retrospective cohort and nested case-control analyses were conducted among 3319 hospital patients on anti-tuberculosis treatment from 1999 to 2005. Each case of CDAD was matched by three sex- and age-matched controls randomly selected from the rest of the cohort. Not every case was confirmed by C. difficile cytotoxins. RESULTS: Among 38 cases studied, the incidence of CDAD, which was 28.2 (95%CI 20.3-38.3) per 100 000 patient-days overall, increased from 12.9 (95%CI 5.8-25.3) for patients aged <60 years to 26.6 (95%CI 15.5-42.8) for those aged between 60 and 79 years, and 66.9 (95%CI 39.8-106.1) for those aged >79 years. Univariate analysis showed a significant association between CDAD and age, FQs, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. Only duration of hospital stay and nasogastric feeding remained significant on multivariable analysis. CONCLUSION: The risk of CDAD due to FQs among TB patients is probably modest after controlling for sex, age, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. © 2009 The Union.
 
ISSN1027-3719
2013 Impact Factor: 2.756
2013 SCImago Journal Rankings: 1.527
 
ISI Accession Number IDWOS:000263846700011
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChang, KC
 
dc.contributor.authorLeung, CC
 
dc.contributor.authorYew, WW
 
dc.contributor.authorLam, FM
 
dc.contributor.authorHo, PL
 
dc.contributor.authorChau, CH
 
dc.contributor.authorCheng, VCC
 
dc.contributor.authorYuen, KY
 
dc.date.accessioned2010-05-31T03:49:34Z
 
dc.date.available2010-05-31T03:49:34Z
 
dc.date.issued2009
 
dc.description.abstractSETTING: Systematic studies of fluoroquinolones (FQs) and Clostridium difficile-associated diarrhoea (CDAD) are scarce among tuberculosis (TB) patients, in whom fluoroquinolones (FQs) are increasingly used. OBJECTIVE: To evaluate the relationship between FQs and CDAD among TB patients. DESIGN: Retrospective cohort and nested case-control analyses were conducted among 3319 hospital patients on anti-tuberculosis treatment from 1999 to 2005. Each case of CDAD was matched by three sex- and age-matched controls randomly selected from the rest of the cohort. Not every case was confirmed by C. difficile cytotoxins. RESULTS: Among 38 cases studied, the incidence of CDAD, which was 28.2 (95%CI 20.3-38.3) per 100 000 patient-days overall, increased from 12.9 (95%CI 5.8-25.3) for patients aged <60 years to 26.6 (95%CI 15.5-42.8) for those aged between 60 and 79 years, and 66.9 (95%CI 39.8-106.1) for those aged >79 years. Univariate analysis showed a significant association between CDAD and age, FQs, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. Only duration of hospital stay and nasogastric feeding remained significant on multivariable analysis. CONCLUSION: The risk of CDAD due to FQs among TB patients is probably modest after controlling for sex, age, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. © 2009 The Union.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationInternational Journal Of Tuberculosis And Lung Disease, 2009, v. 13 n. 3, p. 341-346 [How to Cite?]
 
dc.identifier.epage346
 
dc.identifier.hkuros167104
 
dc.identifier.isiWOS:000263846700011
 
dc.identifier.issn1027-3719
2013 Impact Factor: 2.756
2013 SCImago Journal Rankings: 1.527
 
dc.identifier.issue3
 
dc.identifier.pmid19275794
 
dc.identifier.scopuseid_2-s2.0-62349102110
 
dc.identifier.spage341
 
dc.identifier.urihttp://hdl.handle.net/10722/59412
 
dc.identifier.volume13
 
dc.languageeng
 
dc.publisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
 
dc.publisher.placeFrance
 
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Disease
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAged
 
dc.subject.meshAnti-Bacterial Agents - adverse effects - therapeutic use
 
dc.subject.meshCase-Control Studies
 
dc.subject.meshClostridium Infections - epidemiology - etiology
 
dc.subject.meshComorbidity
 
dc.subject.meshDiarrhea - microbiology
 
dc.subject.meshEnteral Nutrition
 
dc.subject.meshFemale
 
dc.subject.meshFluoroquinolones - adverse effects - therapeutic use
 
dc.subject.meshHumans
 
dc.subject.meshLength of Stay
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshTuberculosis, Pulmonary - drug therapy - epidemiology
 
dc.titleAnalyses of fluoroquinolones and Clostridium difficile-associated diarrhoea in tuberculosis patients
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Chang, KC</contributor.author>
<contributor.author>Leung, CC</contributor.author>
<contributor.author>Yew, WW</contributor.author>
<contributor.author>Lam, FM</contributor.author>
<contributor.author>Ho, PL</contributor.author>
<contributor.author>Chau, CH</contributor.author>
<contributor.author>Cheng, VCC</contributor.author>
<contributor.author>Yuen, KY</contributor.author>
<date.accessioned>2010-05-31T03:49:34Z</date.accessioned>
<date.available>2010-05-31T03:49:34Z</date.available>
<date.issued>2009</date.issued>
<identifier.citation>International Journal Of Tuberculosis And Lung Disease, 2009, v. 13 n. 3, p. 341-346</identifier.citation>
<identifier.issn>1027-3719</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/59412</identifier.uri>
<description.abstract>SETTING: Systematic studies of fluoroquinolones (FQs) and Clostridium difficile-associated diarrhoea (CDAD) are scarce among tuberculosis (TB) patients, in whom fluoroquinolones (FQs) are increasingly used. OBJECTIVE: To evaluate the relationship between FQs and CDAD among TB patients. DESIGN: Retrospective cohort and nested case-control analyses were conducted among 3319 hospital patients on anti-tuberculosis treatment from 1999 to 2005. Each case of CDAD was matched by three sex- and age-matched controls randomly selected from the rest of the cohort. Not every case was confirmed by C. difficile cytotoxins. RESULTS: Among 38 cases studied, the incidence of CDAD, which was 28.2 (95%CI 20.3-38.3) per 100 000 patient-days overall, increased from 12.9 (95%CI 5.8-25.3) for patients aged &lt;60 years to 26.6 (95%CI 15.5-42.8) for those aged between 60 and 79 years, and 66.9 (95%CI 39.8-106.1) for those aged &gt;79 years. Univariate analysis showed a significant association between CDAD and age, FQs, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. Only duration of hospital stay and nasogastric feeding remained significant on multivariable analysis. CONCLUSION: The risk of CDAD due to FQs among TB patients is probably modest after controlling for sex, age, non-FQ antibiotics, serum albumin level, duration of hospital stay and nasogastric feeding. &#169; 2009 The Union.</description.abstract>
<language>eng</language>
<publisher>International Union against Tuberculosis and Lung Disease. The Journal&apos;s web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html</publisher>
<relation.ispartof>International Journal of Tuberculosis and Lung Disease</relation.ispartof>
<subject.mesh>Aged</subject.mesh>
<subject.mesh>Anti-Bacterial Agents - adverse effects - therapeutic use</subject.mesh>
<subject.mesh>Case-Control Studies</subject.mesh>
<subject.mesh>Clostridium Infections - epidemiology - etiology</subject.mesh>
<subject.mesh>Comorbidity</subject.mesh>
<subject.mesh>Diarrhea - microbiology</subject.mesh>
<subject.mesh>Enteral Nutrition</subject.mesh>
<subject.mesh>Female</subject.mesh>
<subject.mesh>Fluoroquinolones - adverse effects - therapeutic use</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Length of Stay</subject.mesh>
<subject.mesh>Male</subject.mesh>
<subject.mesh>Middle Aged</subject.mesh>
<subject.mesh>Tuberculosis, Pulmonary - drug therapy - epidemiology</subject.mesh>
<title>Analyses of fluoroquinolones and Clostridium difficile-associated diarrhoea in tuberculosis patients</title>
<type>Article</type>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.pmid>19275794</identifier.pmid>
<identifier.scopus>eid_2-s2.0-62349102110</identifier.scopus>
<identifier.hkuros>167104</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-62349102110&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>13</identifier.volume>
<identifier.issue>3</identifier.issue>
<identifier.spage>341</identifier.spage>
<identifier.epage>346</identifier.epage>
<identifier.isi>WOS:000263846700011</identifier.isi>
<publisher.place>France</publisher.place>
</item>
Author Affiliations
  1. The University of Hong Kong
  2. Centre for Health Protection
  3. Wanchai Chest Clinic
  4. Grantham Hospital Hong Kong