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Article: Changes in the epidemiology of methicillin-resistant Staphylococcus aureus associated with spread of the ST45 lineage in Hong Kong

TitleChanges in the epidemiology of methicillin-resistant Staphylococcus aureus associated with spread of the ST45 lineage in Hong Kong
Authors
Issue Date2009
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
Citation
Diagnostic Microbiology And Infectious Disease, 2009, v. 64 n. 2, p. 131-137 How to Cite?
AbstractThis study assessed the susceptibility trend of methicillin-resistant Staphylococcus aureus (MRSA) in 5 Hong Kong hospitals from 1995 to 2005. Representative blood isolates were characterized to correlate the changes in resistance phenotypes with the clonal nature of MRSA. The prevalence of multisusceptible (MS) MRSA, defined by sensitivity to gentamicin, co-trimoxazole, and fusidic acid, was found to increase dramatically from <2% in 1995 to 1997 to 4.5% to 5.8% in 1998 to 1999 and remained at around 10% thereafter. Isolation of MS-MRSA was significantly associated with older age, convalescent care, and blood culture source. Molecular typing showed that the increasing isolation of MS-MRSA was associated with the spread of ST45/Staphylococcus cassette chromosome mec (SCCmec) IV or V with spa t1768, t1857, or t1081. Other features of the ST45 strains are as follows: agr4, capsular type 8, and Panton-Valentine leukocidin (PVL) negative. Two other epidemic clones, EMRSA-16 (ST36/SCCmec II) and CC398 (ST1277/SCCmec V), were detected as sporadic isolates for the first time in Hong Kong. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59406
ISSN
2015 Impact Factor: 2.45
2015 SCImago Journal Rankings: 1.142
ISI Accession Number ID
Funding AgencyGrant Number
Control of Infectious Diseases of the Health, Welfare and Food Bureau of the Hong Kong SAR Government
University Development Fund Project-Research Centre of Emerging Infectious Diseases
Funding Information:

The work is supported by research grants from the Research Fund for the Control of Infectious Diseases of the Health, Welfare and Food Bureau of the Hong Kong SAR Government and from the University Development Fund Project-Research Centre of Emerging Infectious Diseases.

References

 

DC FieldValueLanguage
dc.contributor.authorHo, PLen_HK
dc.contributor.authorChow, KHen_HK
dc.contributor.authorLo, PYen_HK
dc.contributor.authorLee, KFen_HK
dc.contributor.authorLai, ELen_HK
dc.date.accessioned2010-05-31T03:49:27Z-
dc.date.available2010-05-31T03:49:27Z-
dc.date.issued2009en_HK
dc.identifier.citationDiagnostic Microbiology And Infectious Disease, 2009, v. 64 n. 2, p. 131-137en_HK
dc.identifier.issn0732-8893en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59406-
dc.description.abstractThis study assessed the susceptibility trend of methicillin-resistant Staphylococcus aureus (MRSA) in 5 Hong Kong hospitals from 1995 to 2005. Representative blood isolates were characterized to correlate the changes in resistance phenotypes with the clonal nature of MRSA. The prevalence of multisusceptible (MS) MRSA, defined by sensitivity to gentamicin, co-trimoxazole, and fusidic acid, was found to increase dramatically from <2% in 1995 to 1997 to 4.5% to 5.8% in 1998 to 1999 and remained at around 10% thereafter. Isolation of MS-MRSA was significantly associated with older age, convalescent care, and blood culture source. Molecular typing showed that the increasing isolation of MS-MRSA was associated with the spread of ST45/Staphylococcus cassette chromosome mec (SCCmec) IV or V with spa t1768, t1857, or t1081. Other features of the ST45 strains are as follows: agr4, capsular type 8, and Panton-Valentine leukocidin (PVL) negative. Two other epidemic clones, EMRSA-16 (ST36/SCCmec II) and CC398 (ST1277/SCCmec V), were detected as sporadic isolates for the first time in Hong Kong. © 2009 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobioen_HK
dc.relation.ispartofDiagnostic Microbiology and Infectious Diseaseen_HK
dc.rightsDiagnostic Microbiology and Infectious Disease. Copyright © Elsevier Inc.en_HK
dc.subject.meshBacterial Capsulesen_HK
dc.subject.meshBacterial Proteins - geneticsen_HK
dc.subject.meshBacterial Toxins - geneticsen_HK
dc.subject.meshBacterial Typing Techniquesen_HK
dc.subject.meshCluster Analysisen_HK
dc.subject.meshDNA Fingerprinting - methodsen_HK
dc.subject.meshDNA, Bacterial - geneticsen_HK
dc.subject.meshExotoxins - geneticsen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHospitalsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLeukocidins - geneticsen_HK
dc.subject.meshMethicillin-Resistant Staphylococcus aureus - classification - genetics - isolation & purificationen_HK
dc.subject.meshMicrobial Sensitivity Testsen_HK
dc.subject.meshMolecular Epidemiologyen_HK
dc.subject.meshStaphylococcal Infections - epidemiology - microbiologyen_HK
dc.subject.meshStaphylococcal Protein A - geneticsen_HK
dc.subject.meshTrans-Activators - geneticsen_HK
dc.titleChanges in the epidemiology of methicillin-resistant Staphylococcus aureus associated with spread of the ST45 lineage in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0732-8893&volume=64&spage=131&epage=7&date=2009&atitle=Changes+in+the+epidemiology+of+methicillin-resistant+Staphylococcus+aureus+associated+with+spread+of+the+ST45+lineage+in+Hong+Kong.en_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.emailChow, KH:khchowb@hku.hken_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityChow, KH=rp00370en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.diagmicrobio.2009.01.030en_HK
dc.identifier.pmid19345036-
dc.identifier.scopuseid_2-s2.0-67349101215en_HK
dc.identifier.hkuros165305en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349101215&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume64en_HK
dc.identifier.issue2en_HK
dc.identifier.spage131en_HK
dc.identifier.epage137en_HK
dc.identifier.isiWOS:000266800600003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridChow, KH=7202180736en_HK
dc.identifier.scopusauthoridLo, PY=26423725900en_HK
dc.identifier.scopusauthoridLee, KF=35205737000en_HK
dc.identifier.scopusauthoridLai, EL=8238477100en_HK
dc.identifier.citeulike5123694-

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