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Article: The role of influenza virus gene constellation and viral morphology on cytokine induction, pathogenesis, and viral virulence.

TitleThe role of influenza virus gene constellation and viral morphology on cytokine induction, pathogenesis, and viral virulence.
Authors
Issue Date2009
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal, 2009, v. 15 suppl. 4, p. 21-23 How to Cite?
AbstractKey Messages 1. H5N1 viruses that cause severe disease in humans are potent inducers of proinflammatory cytokines in contrast to seasonal influenza viruses, and this may play a role in the mechanism of H5N1 pathogenesis. 2. H5N1 viruses are predominantly spherical in morphology. Virus morphology does not influence the ability to induce proinflammatory cytokines. 3. The NS1 viral protein may play a role in the potency of proinflammatory induction. 4. The H5N1 haemagglutinin and neuraminidase do not appear to transfer the high cytokine phenotype. 5. The ability to induce cytokines is a polygenic trait, involving a combination of different viral genes.
Persistent Identifierhttp://hdl.handle.net/10722/59390
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorPeiris, JSen_HK
dc.contributor.authorPoon, LMen_HK
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2010-05-31T03:49:07Z-
dc.date.available2010-05-31T03:49:07Z-
dc.date.issued2009en_HK
dc.identifier.citationHong Kong Medical Journal, 2009, v. 15 suppl. 4, p. 21-23en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59390-
dc.description.abstractKey Messages 1. H5N1 viruses that cause severe disease in humans are potent inducers of proinflammatory cytokines in contrast to seasonal influenza viruses, and this may play a role in the mechanism of H5N1 pathogenesis. 2. H5N1 viruses are predominantly spherical in morphology. Virus morphology does not influence the ability to induce proinflammatory cytokines. 3. The NS1 viral protein may play a role in the potency of proinflammatory induction. 4. The H5N1 haemagglutinin and neuraminidase do not appear to transfer the high cytokine phenotype. 5. The ability to induce cytokines is a polygenic trait, involving a combination of different viral genes.-
dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_HK
dc.relation.ispartofHong Kong Medical Journalen_HK
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCells, Cultured-
dc.subject.meshInfluenza A Virus, H5N1 Subtype - genetics - pathogenicity-
dc.subject.meshMacrophages - virology-
dc.subject.meshTumor Necrosis Factor-alpha - metabolism-
dc.subject.meshViral Nonstructural Proteins - genetics-
dc.titleThe role of influenza virus gene constellation and viral morphology on cytokine induction, pathogenesis, and viral virulence.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=15&issue=3 Suppl 4&spage=21&epage=3&date=2009&atitle=The+role+of+influenza+virus+gene+constellation+and+viral+morphology+on+cytokine+induction,+pathogenesis,+and+viral+virulenceen_HK
dc.identifier.emailPeiris, JS: malik@hkucc.hku.hken_HK
dc.identifier.emailPoon, LM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailNicholls, JM: jmnichol@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authorityPeiris, JS=rp00410en_HK
dc.identifier.authorityPoon, LM=rp00484en_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.pmid19509433-
dc.identifier.scopuseid_2-s2.0-68849122815en_HK
dc.identifier.hkuros162145en_HK
dc.identifier.volume15en_HK
dc.identifier.issuesuppl. 4en_HK
dc.identifier.spage21en_HK
dc.identifier.epage23en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridPeiris, JS=7005486823en_HK
dc.identifier.scopusauthoridPoon, LM=7005441747en_HK
dc.identifier.scopusauthoridNicholls, JM=7201463077en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK

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