File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Targeting apoptosis as an approach for gastrointestinal cancer therapy

TitleTargeting apoptosis as an approach for gastrointestinal cancer therapy
Authors
KeywordsApoptosis
Colon cancer
Gastric cancer
Therapy
Issue Date2009
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/drup
Citation
Drug Resistance Updates, 2009, v. 12 n. 3, p. 55-64 How to Cite?
AbstractCancers in the gastrointestinal system account for a large proportion of malignancies and cancer-related deaths with gastric cancer and colorectal cancer being the most common ones. For those patients in whom surgical resection is not possible, other therapeutic approaches are necessary. Disordered apoptosis has been linked to cancer development and treatment resistance. Apoptosis occurs via extrinsic or intrinsic signaling each triggered and regulated by many different molecular pathways. In recent years, the selective induction of apoptosis in tumor cells has been increasingly recognized as a promising approach for cancer therapy. A detailed understanding of the molecular pathways involved in the regulation of apoptosis is essential for developing novel effective therapeutic approaches. Apoptosis can be induced by many different approaches including activating cell surface death receptors (for example, Fas, TRAIL and TNF receptors), inhibiting cell survival signaling (such as EGFR, MAPK and PI3K), altering apoptosis threshold by modulating pro-apoptotic and anti-apoptotic members of the Bcl-2 family, down-regulating anti-apoptosis proteins (such as XIAP, survivin and c-IAP2), and using other pro-apoptotic agents. In this review, the authors reviewed the currently reported apoptosis-targeting approaches in gastrointestinal cancers. © 2009 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/59365
ISSN
2015 Impact Factor: 7.95
2015 SCImago Journal Rankings: 3.931
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQiao, Len_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-05-31T03:48:31Z-
dc.date.available2010-05-31T03:48:31Z-
dc.date.issued2009en_HK
dc.identifier.citationDrug Resistance Updates, 2009, v. 12 n. 3, p. 55-64en_HK
dc.identifier.issn1368-7646en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59365-
dc.description.abstractCancers in the gastrointestinal system account for a large proportion of malignancies and cancer-related deaths with gastric cancer and colorectal cancer being the most common ones. For those patients in whom surgical resection is not possible, other therapeutic approaches are necessary. Disordered apoptosis has been linked to cancer development and treatment resistance. Apoptosis occurs via extrinsic or intrinsic signaling each triggered and regulated by many different molecular pathways. In recent years, the selective induction of apoptosis in tumor cells has been increasingly recognized as a promising approach for cancer therapy. A detailed understanding of the molecular pathways involved in the regulation of apoptosis is essential for developing novel effective therapeutic approaches. Apoptosis can be induced by many different approaches including activating cell surface death receptors (for example, Fas, TRAIL and TNF receptors), inhibiting cell survival signaling (such as EGFR, MAPK and PI3K), altering apoptosis threshold by modulating pro-apoptotic and anti-apoptotic members of the Bcl-2 family, down-regulating anti-apoptosis proteins (such as XIAP, survivin and c-IAP2), and using other pro-apoptotic agents. In this review, the authors reviewed the currently reported apoptosis-targeting approaches in gastrointestinal cancers. © 2009 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/drupen_HK
dc.relation.ispartofDrug Resistance Updatesen_HK
dc.subjectApoptosisen_HK
dc.subjectColon canceren_HK
dc.subjectGastric canceren_HK
dc.subjectTherapyen_HK
dc.subject.meshAntineoplastic Agents - therapeutic useen_HK
dc.subject.meshApoptosis - drug effects - physiologyen_HK
dc.subject.meshApoptosis Regulatory Proteins - drug effectsen_HK
dc.subject.meshCell Survival - drug effectsen_HK
dc.subject.meshClinical Trials as Topicen_HK
dc.subject.meshDrug Delivery Systemsen_HK
dc.subject.meshGastrointestinal Neoplasms - drug therapyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshModels, Biologicalen_HK
dc.subject.meshProto-Oncogene Proteins c-bcl-2 - physiologyen_HK
dc.subject.meshSignal Transduction - drug effectsen_HK
dc.titleTargeting apoptosis as an approach for gastrointestinal cancer therapyen_HK
dc.typeArticleen_HK
dc.identifier.emailQiao, L: lq8688@hotmail.comen_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.authorityQiao, L=rp00513en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.drup.2009.02.002en_HK
dc.identifier.pmid19278896-
dc.identifier.scopuseid_2-s2.0-67349150698en_HK
dc.identifier.hkuros155759en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349150698&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue3en_HK
dc.identifier.spage55en_HK
dc.identifier.epage64en_HK
dc.identifier.isiWOS:000267780400001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridQiao, L=7202151719en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats